dihydrotestosterone [Ligand Id: 2856] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL27769 (Androstanolone, Stanolone, NSC-10972, Neodrol, 5alpha-dihydrotestosterone)
  • Androgen receptor/Androgen Receptor in Human [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275]
  • Androgen receptor/Androgen Receptor in Mouse [ChEMBL: CHEMBL3056] [GtoPdb: 628] [UniProtKB: P19091]
  • Androgen receptor/Androgen Receptor in Rat [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
1 CHEMBL27769_lig_chart_1 Androgen Receptor HumanMouseRat
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  • Corticosteroid binding globulin in Human [ChEMBL: CHEMBL2421] [UniProtKB: P08185]
  • This target only has 1 pki data point
2 CHEMBL27769_lig_chart_2 Corticosteroid binding globulin Human
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3 CHEMBL27769_lig_chart_3 Cytochrome P450 19A1 Human
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  • Glucocorticoid receptor in Human [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150]
  • Glucocorticoid receptor in Rat [ChEMBL: CHEMBL3368] [GtoPdb: 625] [UniProtKB: P06536]
  • This target only has 0 pki data point
4 CHEMBL27769_lig_chart_4 Glucocorticoid receptor HumanRat
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  • GPBA receptor/G-protein coupled bile acid receptor 1 in Human [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
  • This target only has 0 pki data point
5 CHEMBL27769_lig_chart_5 G-protein coupled bile acid receptor 1 Human
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  • Mineralocorticoid receptor in Human [ChEMBL: CHEMBL1994] [GtoPdb: 626] [UniProtKB: P08235]
  • Mineralocorticoid receptor in Rat [ChEMBL: CHEMBL3507] [GtoPdb: 626] [UniProtKB: P22199]
  • This target only has 0 pki data point
6 CHEMBL27769_lig_chart_6 Mineralocorticoid receptor HumanRat
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  • Progesterone receptor in Human [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401]
  • Progesterone receptor in Bovine [ChEMBL: CHEMBL1909044] [UniProtKB: Q690N0]
  • Progesterone receptor in Rabbit [ChEMBL: CHEMBL3456] [UniProtKB: P06186]
  • This target only has 1 pki data point
7 CHEMBL27769_lig_chart_7 Progesterone receptor HumanBovineRabbit
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  • Testis-specific androgen-binding protein in Human [ChEMBL: CHEMBL3305] [UniProtKB: P04278]
  • Testis-specific androgen-binding protein in Rat [ChEMBL: CHEMBL4932] [UniProtKB: P08689]
  • This target only has 0 pki data point
8 CHEMBL27769_lig_chart_8 Testis-specific androgen-binding protein HumanRat
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275]
GtoPdb - - 9.3 pKd 0.5 nM Kd Proc. Natl. Acad. Sci. U.S.A. (1989) 86: 327-31 [PMID:2911578]
ChEMBL Displacement of fluorescent-tagged R1881 from androgen receptor after 4 hrs by fluorometric assay B 8 pKi 10 nM Ki ACS Med. Chem. Lett. (2011) 2: 124-129 [PMID:24900290]
ChEMBL Displacement of [3H]DHT from human androgen receptor after 16 hrs by scintillation counting B 8.33 pKi 4.7 nM Ki Bioorg. Med. Chem. (2010) 18: 4255-4268 [PMID:20510622]
ChEMBL Binding affinity for human Androgen receptor expressed in COS-1 cells B 8.52 pKi 3 nM Ki J. Med. Chem. (1999) 42: 210-212 [PMID:9925725]
ChEMBL Binding affinity to the human androgen receptor (hAR), using [3H]DHT as radioligand in a competitive binding assay B 8.7 pKi 2 nM Ki Bioorg. Med. Chem. Lett. (1999) 9: 1335-1340 [PMID:10340624]
ChEMBL Binding affinity against Androgen receptor expressed COS cells B 8.7 pKi 2 nM Ki Bioorg. Med. Chem. Lett. (1998) 8: 745-750 [PMID:9871534]
ChEMBL Binding affinity towards human androgen receptor (hAR), using dihydrotestosterone as radioligand for competitive binding assay B 8.7 pKi 2 nM Ki Bioorg. Med. Chem. Lett. (1999) 9: 1009-1012 [PMID:10230629]
ChEMBL Displacement of [3H]DHT from human Androgen receptor in human MDA-MB-453 cells B 9.05 pKi 0.9 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 2967-2971 [PMID:18400499]
ChEMBL Displacement of [3H]DHT from human AR expressed in MDA-MB-453 cells B 9.52 pKi 0.3 nM Ki J. Med. Chem. (2007) 50: 2486-2496 [PMID:17439112]
ChEMBL Displacement of [3H]DHT from human AR in MDA453 cells B 9.52 pKi 0.3 nM Ki J. Med. Chem. (2006) 49: 7596-7599 [PMID:17181141]
ChEMBL Binding affinity to human AR B 9.7 pKi 0.2 nM Ki Bioorg. Med. Chem. Lett. (2007) 17: 1527-1531 [PMID:17267219]
ChEMBL Binding affinity to human androgen receptor expressed in CV1 cells B 9.7 pKi 0.2 nM Ki Bioorg. Med. Chem. Lett. (2007) 17: 1523-1526 [PMID:17257838]
ChEMBL Binding affinity to human androgen receptor expressed in monkey COS7 cells by whole cell binding assay B 9.7 pKi 0.2 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 3431-3435 [PMID:18442912]
ChEMBL Displacement of [3H]DHT from human androgen receptor expressed in MDA-MB-453 cells by whole cell receptor binding assay B 9.7 pKi 0.2 nM Ki J. Med. Chem. (2006) 49: 6143-6146 [PMID:17034117]
ChEMBL Binding affinity to human AR B 9.7 pKi 0.2 nM Ki J. Med. Chem. (2007) 50: 5049-5052 [PMID:17887661]
ChEMBL Antagonistic activity against human androgen receptor (hAR) in CV-1 cells using cotransfection assay F 5 pIC50 >10000 nM IC50 Bioorg. Med. Chem. Lett. (1999) 9: 1335-1340 [PMID:10340624]
ChEMBL Antagonistic activity against human androgen receptor (hAR) expressed in CV-1 cell lines F 5 pIC50 >10000 nM IC50 Bioorg. Med. Chem. Lett. (1999) 9: 1009-1012 [PMID:10230629]
ChEMBL Antagonist activity against human androgen receptor in CV1 cells measured as inhibition of DHT-stimulated luciferase reporter gene activity by cotransfection assay F 5 pIC50 >10000 nM IC50 J. Med. Chem. (2006) 49: 6143-6146 [PMID:17034117]
ChEMBL Antagonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assay F 5 pIC50 >10000 nM IC50 J. Med. Chem. (2007) 50: 2486-2496 [PMID:17439112]
ChEMBL Antagonist activity at human androgen receptor by luciferase reporter gene assay F 5 pIC50 >10000 nM IC50 J. Med. Chem. (2007) 50: 5049-5052 [PMID:17887661]
ChEMBL Antagonist activity at human AR F 5 pIC50 >10000 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 1527-1531 [PMID:17267219]
ChEMBL Antagonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assay F 5 pIC50 >10000 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 5442-5446 [PMID:17703938]
ChEMBL Antagonist activity at human androgen receptor african green monkey CV1 cells by cotransfection assay F 5 pIC50 >10000 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 3431-3435 [PMID:18442912]
ChEMBL Antagonist activity at human androgen receptor expressed in COS7 cells assessed as inhibition of DHT-induced luciferase activity after 24 hrs by reporter gene assay F 5 pIC50 >10000 nM IC50 Bioorg. Med. Chem. (2012) 20: 422-434 [PMID:22094279]
ChEMBL Antagonist activity at wild type Androgen receptor (unknown origin) expressed in human Cos-7 cells co-expressing pGL3-MMTV-luc vector assessed as luciferase activity by reporter gene assay B 5 pIC50 >10000 nM IC50 Bioorg. Med. Chem. (2013) 21: 70-83 [PMID:23199477]
ChEMBL Competitive inhibition of androgen binding to androgen receptor (unknown origin) by invitrogen polar screen assay B 7.88 pIC50 13.1 nM IC50 J. Med. Chem. (2015) 58: 6984-6993 [PMID:26305181]
ChEMBL Displacement of [3H]mibolerone from human AR expressed in COS cells after 3.5 hrs by liquid scintillation counting analysis B 7.96 pIC50 11 nM IC50 MedChemComm (2013) 4: 582-589
ChEMBL Binding affinity to androgen receptor by fluorescence binding assay B 8 pIC50 10 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 7516-7520 [PMID:21036041]
ChEMBL In vitro antagonistic activity against human androgen receptor using cotransfection assay in CV-1 cells; Not active. F 8 pIC50 >10 nM IC50 Bioorg. Med. Chem. Lett. (1999) 9: 1003-1008 [PMID:10230628]
ChEMBL In vitro binding affinity at human androgen receptor transfected into COS cells. B 8.4 pIC50 4 nM IC50 Bioorg. Med. Chem. Lett. (1999) 9: 1003-1008 [PMID:10230628]
ChEMBL Displacement of [17-alpha-methyl-3H]-mibolerone from human androgen receptor expressed in HEK293 derived FreeStyle293F cells after 3 hrs B 8.68 pIC50 2.1 nM IC50 Bioorg. Med. Chem. (2012) 20: 422-434 [PMID:22094279]
ChEMBL Inhibition of wild type Androgen receptor (unknown origin) expressed in Freestyle293F cells B 8.68 pIC50 2.1 nM IC50 Bioorg. Med. Chem. (2013) 21: 70-83 [PMID:23199477]
ChEMBL Activity against human androgen receptor expressed in HepG2 cells assessed as luciferase reporter gene activation B 8.74 pIC50 1.82 nM IC50 J. Med. Chem. (2006) 49: 7366-7372 [PMID:17149866]
ChEMBL Displacement of [3H]methyltrienolone from androgen receptor in human MDA-MB-453 cells B 9 pIC50 1 nM IC50 J. Med. Chem. (2009) 52: 4578-4581 [PMID:19606870]
ChEMBL Displacement of [3H]mibolerone from human AR after 3 hrs B 9.17 pIC50 0.67 nM IC50 Bioorg Med Chem (2017) 25: 3330-3349 [PMID:28454849]
ChEMBL Activity at androgen receptor in human Saos2 cells assessed as IL6 repression B 10.3 pIC50 0.05 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 3431-3435 [PMID:18442912]
ChEMBL Agonist activity at androgen receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-DBD by luciferase reporter gene assay B 7.7 pEC50 20 nM EC50 J. Nat. Prod. (2009) 72: 1944-1948 [PMID:19863083]
ChEMBL Agonist activity at wild type Androgen receptor in human LNCaP-hr cells assessed as prostate specific antigen secretion measured after 3 days by enzyme-immunoassay B 8.21 pEC50 6.2 nM EC50 Bioorg. Med. Chem. (2013) 21: 70-83 [PMID:23199477]
ChEMBL Agonist activity at human androgen receptor expressed in COS7 cells assessed as luciferase activity after 24 hrs by reporter gene assay F 8.21 pEC50 6.2 nM EC50 Bioorg. Med. Chem. (2012) 20: 422-434 [PMID:22094279]
ChEMBL Agonist activity to the human androgen receptor (hAR) in CV-1 cells F 8.22 pEC50 6 nM EC50 Bioorg. Med. Chem. Lett. (1999) 9: 1335-1340 [PMID:10340624]
ChEMBL Agonistic activity against human androgen receptor (hAR) expressed in CV-1 cell lines F 8.22 pEC50 6 nM EC50 Bioorg. Med. Chem. Lett. (1999) 9: 1009-1012 [PMID:10230629]
ChEMBL Agonistic activity (EC50) against human androgen receptor expressed in CV-1 cell F 8.22 pEC50 6 nM EC50 Bioorg. Med. Chem. Lett. (1998) 8: 745-750 [PMID:9871534]
ChEMBL In vitro agonistic activity against human androgen receptor using cotransfection assay in CV-1 cells. F 8.22 pEC50 6 nM EC50 Bioorg. Med. Chem. Lett. (1999) 9: 1003-1008 [PMID:10230628]
ChEMBL Agonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assay F 8.24 pEC50 5.7 nM EC50 Bioorg. Med. Chem. Lett. (2007) 17: 5442-5446 [PMID:17703938]
ChEMBL Agonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assay F 8.24 pEC50 5.7 nM EC50 J. Med. Chem. (2007) 50: 2486-2496 [PMID:17439112]
ChEMBL Agonist activity at human androgen receptor in CV1 cells by transcriptional activation assay F 8.24 pEC50 5.7 nM EC50 Bioorg. Med. Chem. Lett. (2008) 18: 2967-2971 [PMID:18400499]
ChEMBL Agonist activity at human androgen receptor by luciferase reporter gene assay F 8.29 pEC50 5.1 nM EC50 J. Med. Chem. (2007) 50: 5049-5052 [PMID:17887661]
ChEMBL Agonist activity at human androgen receptor african green monkey CV1 cells by cotransfection assay F 8.29 pEC50 5.1 nM EC50 Bioorg. Med. Chem. Lett. (2008) 18: 3431-3435 [PMID:18442912]
ChEMBL Agonist activity at human androgen receptor expressed in CV1 cells F 8.29 pEC50 5.1 nM EC50 Bioorg. Med. Chem. Lett. (2007) 17: 1523-1526 [PMID:17257838]
ChEMBL Agonist activity at human androgen receptor in CV1 cells measured as stimulation of luciferase reporter gene activity by cotransfection assay F 8.29 pEC50 5.1 nM EC50 J. Med. Chem. (2006) 49: 6143-6146 [PMID:17034117]
ChEMBL Agonist activity at human AR F 8.29 pEC50 5.1 nM EC50 Bioorg. Med. Chem. Lett. (2007) 17: 1527-1531 [PMID:17267219]
ChEMBL Agonist activity against Human Androgen receptor expressed in CV-1 cells F 8.3 pEC50 5 nM EC50 J. Med. Chem. (1999) 42: 210-212 [PMID:9925725]
ChEMBL Agonist activity at human AR expressed in African green monkey COS7 cells after 24 hrs by luciferase reporter gene assay B 8.52 pEC50 3 nM EC50 Bioorg Med Chem (2017) 25: 3330-3349 [PMID:28454849]
ChEMBL Agonist activity at androgen receptor in human MDA-MB-453 cells transfected with MMTV-LUC assessed as induction of MMTV-LTR/promoter linked LUC gene by luciferase transactivation assay F 8.7 pEC50 2 nM EC50 J. Med. Chem. (2009) 52: 4578-4581 [PMID:19606870]
ChEMBL Agonist activity at human androgen receptor expressed in HEK293 cells by luciferase reporter gene assay B 9.74 pEC50 0.18 nM EC50 Bioorg. Med. Chem. Lett. (2014) 24: 5265-5267 [PMID:25305688]
ChEMBL Agonist activity at human androgen receptor expressed in mouse C2C12 cells by androgen-specific response element-driven luciferase reporter gene assay B 9.89 pEC50 0.13 nM EC50 J. Med. Chem. (2014) 57: 7396-7411 [PMID:25121964]
ChEMBL Agonist activity at androgen receptor expressed in mouse C2C12 cells assessed as osteoblast differentiation after 5 days F 10.3 pEC50 0.05 nM EC50 ACS Med. Chem. Lett. (2011) 2: 124-129 [PMID:24900290]
Androgen receptor/Androgen Receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3056] [GtoPdb: 628] [UniProtKB: P19091]
ChEMBL Displacement of [3H] ]5alpha-DHT from mouse androgen receptor expressed in monkey COS7 cells after 2 hrs by scintillation counting analysis B 9 pIC50 1 nM IC50 J. Med. Chem. (2013) 56: 3414-3418 [PMID:23527816]
ChEMBL Agonist activity at androgen receptor in mouse NIH3T3 cells transiently transfected with beta-galactosidase reporter gene assessed as cellular transformation by R-SAT assay F 8.4 pEC50 3.98 nM EC50 J. Med. Chem. (2009) 52: 7186-7191 [PMID:19856921]
Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
ChEMBL DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) B 8.81 pKi 1.54 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL Inhibitory constant against rat prostate cytosol androgen receptor using [3H]mibolerone B 9.16 pKi 0.69 nM Ki J. Med. Chem. (2000) 43: 3344-3347 [PMID:10966753]
ChEMBL Inhibition of [3H]mibolerone binding to cytosolic androgen receptor of rat ventral prostate B 9.55 pKi 0.28 nM Ki J. Med. Chem. (2005) 48: 917-925 [PMID:15715462]
ChEMBL Binding affinity to rat androgen receptor by competitive inhibition assay B 9.57 pKi 0.27 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 5567-5570 [PMID:18805694]
ChEMBL Ability to inhibit binding of [3H]R-1881 to rat ventral prostate cytosolic androgen receptor was measured in a radioligand binding assay. B 5.49 pIC50 3200 nM IC50 J. Med. Chem. (2000) 43: 4629-4635 [PMID:11101354]
ChEMBL Displacement of androgen fluormone from rat androgen receptor B 7.73 pIC50 18.5 nM IC50 J. Med. Chem. (2006) 49: 7366-7372 [PMID:17149866]
ChEMBL Displacement of [3H]testosterone from Sprague-Dawley rat AR by liquid scintillation counting B 8.51 pIC50 3.1 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 1744-1747 [PMID:21349712]
ChEMBL Competitive binding affinity to rat androgen receptor B 8.51 pIC50 3.1 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 6310-6313 [PMID:21944856]
ChEMBL DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) B 8.64 pIC50 2.31 nM IC50 DrugMatrix in vitro pharmacology data
ChEMBL Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) B 8.65 pIC50 2.24 nM IC50 J. Med. Chem. (2005) 48: 5666-5674 [PMID:16134935]
GtoPdb - - 8.65 pIC50 - - - Chem. Res. Toxicol. (2003) 16: 1338-58 [PMID:14565775]
ChEMBL In vitro antagonist activity against rat prostatic androgen receptor (AR) F 8.66 pIC50 2.2 nM IC50 J. Med. Chem. (1986) 29: 2298-2315 [PMID:3783591]
ChEMBL Displacement of [3H]testosterone from androgen receptor in Sprague-Dawley rat prostate gland after 2 hrs by liquid scintillation counting B 8.7 pIC50 2 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 6310-6313 [PMID:21944856]
ChEMBL Agonist activity at rat AR transfected in mouse C2C12 cells by luciferase reporter transactivation assay F 8.55 pEC50 2.8 nM EC50 J. Med. Chem. (2006) 49: 7596-7599 [PMID:17181141]
ChEMBL Agonist activity at rat androgen receptor F 9.01 pEC50 0.97 nM EC50 Bioorg. Med. Chem. Lett. (2011) 21: 6310-6313 [PMID:21944856]
Corticosteroid binding globulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2421] [UniProtKB: P08185]
ChEMBL In silico binding affinity to human corticosteriod binding globulin B 4.92 pKd 4.92 - -Log Kdiss J. Med. Chem. (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL Binding affinity to human CBG receptor (corticosteroid-binding globulins) B 5.92 pKi 1202.26 nM Ki J. Med. Chem. (2004) 47: 2732-2742 [PMID:15139751]
CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511]
ChEMBL Inactivation rate (Ki) for human placental Cytochrome P450 19A1 B 5.81 pKi 1550 nM Ki J. Med. Chem. (1989) 32: 651-658 [PMID:2918514]
ChEMBL Competitive inhibition of binding to human placental Cytochrome P450 19A1 B 6.66 pKi 220 nM Ki J. Med. Chem. (1989) 32: 651-658 [PMID:2918514]
Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150]
ChEMBL Binding affinity to GR (unknown origin) B 6.27 pIC50 540 nM IC50 Bioorg Med Chem (2017) 25: 3330-3349 [PMID:28454849]
Glucocorticoid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3368] [GtoPdb: 625] [UniProtKB: P06536]
ChEMBL Displacement of [3H]dexamethasone from Sprague-Dawley rat GR by liquid scintillation counting B 4.7 pIC50 20000 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 1744-1747 [PMID:21349712]
ChEMBL Displacement of [3H]Dex from glucocorticoid receptor in Sprague-Dawley rat liver after 2 hrs by liquid scintillation counting B 4.7 pIC50 20000 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 6310-6313 [PMID:21944856]
GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
ChEMBL Agonist activity at human TGR5 expressed in CHO cells by luciferase assay F 5.35 pEC50 4490 nM EC50 J. Med. Chem. (2008) 51: 1831-1841 [PMID:18307294]
Mineralocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1994] [GtoPdb: 626] [UniProtKB: P08235]
ChEMBL Binding affinity to MR (unknown origin) B 6.44 pIC50 360 nM IC50 Bioorg Med Chem (2017) 25: 3330-3349 [PMID:28454849]
Mineralocorticoid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3507] [GtoPdb: 626] [UniProtKB: P22199]
ChEMBL Displacement of [3H]aldosterone from Sprague-Dawley rat MR by liquid scintillation counting B 5.68 pIC50 2100 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 1744-1747 [PMID:21349712]
ChEMBL Displacement of [3H]Aldo from mineralocorticoid receptor in Sprague-Dawley rat kidney after 2 hrs by liquid scintillation counting B 5.68 pIC50 2100 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 6310-6313 [PMID:21944856]
Progesterone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401]
ChEMBL Binding affinity to PR (unknown origin) B 5.14 pIC50 7300 nM IC50 Bioorg Med Chem (2017) 25: 3330-3349 [PMID:28454849]
ChEMBL Agonist activity at PR (unknown origin) by luciferase reporter gene assay B 5.09 pEC50 8200 nM EC50 Bioorg Med Chem (2017) 25: 3330-3349 [PMID:28454849]
Progesterone receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1909044] [UniProtKB: Q690N0]
ChEMBL DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) B 6.79 pKi 163 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) B 5.9 pIC50 1247 nM IC50 DrugMatrix in vitro pharmacology data
Progesterone receptor in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3456] [UniProtKB: P06186]
ChEMBL Displacement of [3H]progesterone from rabbit PR by liquid scintillation counting B 6.36 pIC50 440 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 1744-1747 [PMID:21349712]
ChEMBL Displacement of [3H]progesterone from progesterone receptor in JW rabbit uterus after 2 hrs by liquid scintillation counting B 6.36 pIC50 440 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 6310-6313 [PMID:21944856]
Testis-specific androgen-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3305] [UniProtKB: P04278]
ChEMBL Binding affinity towards human testosterone binding globulin. B 8.74 pKd 8.74 - -Log Kdiss J. Med. Chem. (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin B 9.74 pKd 0.18 nM Kd J. Med. Chem. (2008) 51: 2047-2056 [PMID:18330978]
ChEMBL Inhibition of hSHBG (human sex hormone binding globulin ) F 8.42 pIC50 3.8 nM IC50 J. Med. Chem. (1990) 33: 129-132 [PMID:2296011]
Testis-specific androgen-binding protein in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4932] [UniProtKB: P08689]
ChEMBL Inhibition of rat androgen binding protein (rABP) F 7.64 pIC50 23 nM IC50 J. Med. Chem. (1990) 33: 129-132 [PMID:2296011]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]