ChEMBL ligand: CHEMBL27769 (4-dihydrotestosterone, 5alpha-dihydrotestosterone, Anabolex, Andractim, Androstanolone, Dihydrotestosterone, Dihydrotestosterone (dht), Neodrol, NSC-10972, Stanolone)
Androgen receptor/Androgen Receptor in Human [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275] Androgen receptor/Androgen Receptor in Mouse [ChEMBL: CHEMBL3056] [GtoPdb: 628] [UniProtKB: P19091] Androgen receptor/Androgen Receptor in Rat [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207] There should be some charts here, you may need to enable JavaScript!
Corticosteroid binding globulin in Human [ChEMBL: CHEMBL2421] [UniProtKB: P08185] There should be some charts here, you may need to enable JavaScript!
CYP19A1/Cytochrome P450 19A1 in Human [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] There should be some charts here, you may need to enable JavaScript!
Glucocorticoid receptor in Human [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150] Glucocorticoid receptor in Rat [ChEMBL: CHEMBL3368] [GtoPdb: 625] [UniProtKB: P06536] There should be some charts here, you may need to enable JavaScript!
GPBA receptor/G-protein coupled bile acid receptor 1 in Human [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6] There should be some charts here, you may need to enable JavaScript!
Mineralocorticoid receptor in Human [ChEMBL: CHEMBL1994] [GtoPdb: 626] [UniProtKB: P08235] Mineralocorticoid receptor in Rat [ChEMBL: CHEMBL3507] [GtoPdb: 626] [UniProtKB: P22199] There should be some charts here, you may need to enable JavaScript!
Progesterone receptor in Human [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401] Progesterone receptor in Bovine [ChEMBL: CHEMBL1909044] [UniProtKB: Q690N0] Progesterone receptor in Rabbit [ChEMBL: CHEMBL3456] [UniProtKB: P06186] There should be some charts here, you may need to enable JavaScript!
Testis-specific androgen-binding protein in Human [ChEMBL: CHEMBL3305] [UniProtKB: P04278] Testis-specific androgen-binding protein in Rat [ChEMBL: CHEMBL4932] [UniProtKB: P08689] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275]
GtoPdb	-	-	9.3	pKd	0.5	nM	Kd	Proc Natl Acad Sci USA (1989) 86: 327-31 [PMID:2911578]
ChEMBL	Displacement of fluorescent-tagged R1881 from androgen receptor after 4 hrs by fluorometric assay	B	8	pKi	10	nM	Ki	ACS Med. Chem. Lett. (2011) 2: 124-129 [PMID:24900290]
ChEMBL	Displacement of [3H]DHT from human androgen receptor after 16 hrs by scintillation counting	B	8.33	pKi	4.7	nM	Ki	Bioorg. Med. Chem. (2010) 18: 4255-4268 [PMID:20510622]
ChEMBL	Binding affinity for human Androgen receptor expressed in COS-1 cells	B	8.52	pKi	3	nM	Ki	J. Med. Chem. (1999) 42: 210-212 [PMID:9925725]
ChEMBL	Binding affinity to the human androgen receptor (hAR), using [3H]DHT as radioligand in a competitive binding assay	B	8.7	pKi	2	nM	Ki	Bioorg. Med. Chem. Lett. (1999) 9: 1335-1340 [PMID:10340624]
ChEMBL	Binding affinity against Androgen receptor expressed COS cells	B	8.7	pKi	2	nM	Ki	Bioorg. Med. Chem. Lett. (1998) 8: 745-750 [PMID:9871534]
ChEMBL	Binding affinity towards human androgen receptor (hAR), using dihydrotestosterone as radioligand for competitive binding assay	B	8.7	pKi	2	nM	Ki	Bioorg. Med. Chem. Lett. (1999) 9: 1009-1012 [PMID:10230629]
ChEMBL	Displacement of [3H]DHT from human Androgen receptor in human MDA-MB-453 cells	B	9.05	pKi	0.9	nM	Ki	Bioorg. Med. Chem. Lett. (2008) 18: 2967-2971 [PMID:18400499]
ChEMBL	Displacement of [3H]DHT from human AR expressed in MDA-MB-453 cells	B	9.52	pKi	0.3	nM	Ki	J. Med. Chem. (2007) 50: 2486-2496 [PMID:17439112]
ChEMBL	Displacement of [3H]DHT from human AR in MDA453 cells	B	9.52	pKi	0.3	nM	Ki	J. Med. Chem. (2006) 49: 7596-7599 [PMID:17181141]
ChEMBL	Binding affinity to human AR	B	9.7	pKi	0.2	nM	Ki	Bioorg. Med. Chem. Lett. (2007) 17: 1527-1531 [PMID:17267219]
ChEMBL	Binding affinity to human androgen receptor expressed in CV1 cells	B	9.7	pKi	0.2	nM	Ki	Bioorg. Med. Chem. Lett. (2007) 17: 1523-1526 [PMID:17257838]
ChEMBL	Binding affinity to human androgen receptor expressed in monkey COS7 cells by whole cell binding assay	B	9.7	pKi	0.2	nM	Ki	Bioorg. Med. Chem. Lett. (2008) 18: 3431-3435 [PMID:18442912]
ChEMBL	Displacement of [3H]DHT from human androgen receptor expressed in MDA-MB-453 cells by whole cell receptor binding assay	B	9.7	pKi	0.2	nM	Ki	J. Med. Chem. (2006) 49: 6143-6146 [PMID:17034117]
ChEMBL	Binding affinity to human AR	B	9.7	pKi	0.2	nM	Ki	J. Med. Chem. (2007) 50: 5049-5052 [PMID:17887661]
ChEMBL	Antagonist activity at human androgen receptor expressed in COS7 cells assessed as inhibition of DHT-induced luciferase activity after 24 hrs by reporter gene assay	F	5	pIC50	>10000	nM	IC50	Bioorg. Med. Chem. (2012) 20: 422-434 [PMID:22094279]
ChEMBL	Antagonistic activity against human androgen receptor (hAR) in CV-1 cells using cotransfection assay	F	5	pIC50	>10000	nM	IC50	Bioorg. Med. Chem. Lett. (1999) 9: 1335-1340 [PMID:10340624]
ChEMBL	Antagonist activity at wild type Androgen receptor (unknown origin) expressed in human Cos-7 cells co-expressing pGL3-MMTV-luc vector assessed as luciferase activity by reporter gene assay	B	5	pIC50	>10000	nM	IC50	Bioorg. Med. Chem. (2013) 21: 70-83 [PMID:23199477]
ChEMBL	Antagonistic activity against human androgen receptor (hAR) expressed in CV-1 cell lines	F	5	pIC50	>10000	nM	IC50	Bioorg. Med. Chem. Lett. (1999) 9: 1009-1012 [PMID:10230629]
ChEMBL	Antagonist activity against human androgen receptor in CV1 cells measured as inhibition of DHT-stimulated luciferase reporter gene activity by cotransfection assay	F	5	pIC50	>10000	nM	IC50	J. Med. Chem. (2006) 49: 6143-6146 [PMID:17034117]
ChEMBL	Antagonist activity at Androgen receptor T877A mutant (unknown origin) expressed in human Cos-7 cells co-expressing pGL3-MMTV-luc vector assessed as luciferase activity by reporter gene assay	B	5	pIC50	>10000	nM	IC50	Bioorg. Med. Chem. (2013) 21: 70-83 [PMID:23199477]
ChEMBL	Antagonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assay	F	5	pIC50	>10000	nM	IC50	J. Med. Chem. (2007) 50: 2486-2496 [PMID:17439112]
ChEMBL	Antagonist activity at human androgen receptor by luciferase reporter gene assay	F	5	pIC50	>10000	nM	IC50	J. Med. Chem. (2007) 50: 5049-5052 [PMID:17887661]
ChEMBL	Antagonist activity at human AR	F	5	pIC50	>10000	nM	IC50	Bioorg. Med. Chem. Lett. (2007) 17: 1527-1531 [PMID:17267219]
ChEMBL	Antagonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assay	F	5	pIC50	>10000	nM	IC50	Bioorg. Med. Chem. Lett. (2007) 17: 5442-5446 [PMID:17703938]
ChEMBL	Antagonist activity at human androgen receptor african green monkey CV1 cells by cotransfection assay	F	5	pIC50	>10000	nM	IC50	Bioorg. Med. Chem. Lett. (2008) 18: 3431-3435 [PMID:18442912]
ChEMBL	Antagonist activity at human androgen receptor W741C mutant expressed in COS7 cells assessed as inhibition of DHT-induced luciferase activity after 24 hrs by reporter gene assay	F	5	pIC50	>10000	nM	IC50	Bioorg. Med. Chem. (2012) 20: 422-434 [PMID:22094279]
ChEMBL	Antagonist activity at human androgen receptor T877A mutant expressed in COS7 cells assessed as inhibition of DHT-induced luciferase activity after 24 hrs by reporter gene assay	F	5	pIC50	>10000	nM	IC50	Bioorg. Med. Chem. (2012) 20: 422-434 [PMID:22094279]
ChEMBL	Displacement of fluormone-AL green from GST-tagged androgen receptor LBD (unknown origin) measured after 4 hrs by fluorescence polarization assay	B	7.74	pIC50	18	nM	IC50	Eur J Med Chem (2020) 192: 112156-112156 [PMID:32114360]
ChEMBL	Competitive inhibition of androgen binding to androgen receptor (unknown origin) by invitrogen polar screen assay	B	7.88	pIC50	13.1	nM	IC50	J. Med. Chem. (2015) 58: 6984-6993 [PMID:26305181]
ChEMBL	Displacement of [3H]mibolerone from human AR expressed in COS cells after 3.5 hrs by liquid scintillation counting analysis	B	7.96	pIC50	11	nM	IC50	MedChemComm (2013) 4: 582-589
ChEMBL	In vitro antagonistic activity against human androgen receptor using cotransfection assay in CV-1 cells; Not active.	F	8	pIC50	>10	nM	IC50	Bioorg. Med. Chem. Lett. (1999) 9: 1003-1008 [PMID:10230628]
ChEMBL	Binding affinity to androgen receptor by fluorescence binding assay	B	8	pIC50	10	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 7516-7520 [PMID:21036041]
ChEMBL	In vitro binding affinity at human androgen receptor transfected into COS cells.	B	8.4	pIC50	4	nM	IC50	Bioorg. Med. Chem. Lett. (1999) 9: 1003-1008 [PMID:10230628]
ChEMBL	Displacement of [17-alpha-methyl-3H]-mibolerone from human androgen receptor T877A mutant expressed in HEK293 derived FreeStyle293F cells after 3 hrs	B	8.59	pIC50	2.6	nM	IC50	Bioorg. Med. Chem. (2012) 20: 422-434 [PMID:22094279]
ChEMBL	Inhibition of Androgen receptor T877A mutant (unknown origin) expressed in Freestyle293F cells	B	8.59	pIC50	2.6	nM	IC50	Bioorg. Med. Chem. (2013) 21: 70-83 [PMID:23199477]
ChEMBL	Displacement of [17-alpha-methyl-3H]-mibolerone from human androgen receptor expressed in HEK293 derived FreeStyle293F cells after 3 hrs	B	8.68	pIC50	2.1	nM	IC50	Bioorg. Med. Chem. (2012) 20: 422-434 [PMID:22094279]
ChEMBL	Inhibition of wild type Androgen receptor (unknown origin) expressed in Freestyle293F cells	B	8.68	pIC50	2.1	nM	IC50	Bioorg. Med. Chem. (2013) 21: 70-83 [PMID:23199477]
ChEMBL	Activity against human androgen receptor expressed in HepG2 cells assessed as luciferase reporter gene activation	B	8.74	pIC50	1.82	nM	IC50	J. Med. Chem. (2006) 49: 7366-7372 [PMID:17149866]
ChEMBL	Displacement of [3H]methyltrienolone from androgen receptor in human MDA-MB-453 cells	B	9	pIC50	1	nM	IC50	J. Med. Chem. (2009) 52: 4578-4581 [PMID:19606870]
ChEMBL	Displacement of [3H]mibolerone from human AR after 3 hrs	B	9.17	pIC50	0.67	nM	IC50	Bioorg Med Chem (2017) 25: 3330-3349 [PMID:28454849]
ChEMBL	Activity at androgen receptor in human Saos2 cells assessed as IL6 repression	B	10.3	pIC50	0.05	nM	IC50	Bioorg. Med. Chem. Lett. (2008) 18: 3431-3435 [PMID:18442912]
ChEMBL	Agonist activity at androgen receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-DBD by luciferase reporter gene assay	B	7.7	pEC50	20	nM	EC50	J. Nat. Prod. (2009) 72: 1944-1948 [PMID:19863083]
ChEMBL	Agonist activity at Androgen receptor T877A mutant in human LNCaP-hr cells assessed as prostate specific antigen secretion measured after 3 days by enzyme-immunoassay	B	7.82	pEC50	15	nM	EC50	Bioorg. Med. Chem. (2013) 21: 70-83 [PMID:23199477]
ChEMBL	Agonist activity at human androgen receptor T877A mutant expressed in COS7 cells assessed as luciferase activity after 24 hrs by reporter gene assay	F	7.82	pEC50	15	nM	EC50	Bioorg. Med. Chem. (2012) 20: 422-434 [PMID:22094279]
ChEMBL	Agonist activity at human androgen receptor W741C mutant expressed in COS7 cells assessed as luciferase activity after 24 hrs by reporter gene assay	F	7.92	pEC50	12	nM	EC50	Bioorg. Med. Chem. (2012) 20: 422-434 [PMID:22094279]
ChEMBL	Agonist activity at wild type Androgen receptor in human LNCaP-hr cells assessed as prostate specific antigen secretion measured after 3 days by enzyme-immunoassay	B	8.21	pEC50	6.2	nM	EC50	Bioorg. Med. Chem. (2013) 21: 70-83 [PMID:23199477]
ChEMBL	Agonist activity at human androgen receptor expressed in COS7 cells assessed as luciferase activity after 24 hrs by reporter gene assay	F	8.21	pEC50	6.2	nM	EC50	Bioorg. Med. Chem. (2012) 20: 422-434 [PMID:22094279]
ChEMBL	Agonist activity to the human androgen receptor (hAR) in CV-1 cells	F	8.22	pEC50	6	nM	EC50	Bioorg. Med. Chem. Lett. (1999) 9: 1335-1340 [PMID:10340624]
ChEMBL	Agonistic activity (EC50) against human androgen receptor expressed in CV-1 cell	F	8.22	pEC50	6	nM	EC50	Bioorg. Med. Chem. Lett. (1998) 8: 745-750 [PMID:9871534]
ChEMBL	In vitro agonistic activity against human androgen receptor using cotransfection assay in CV-1 cells.	F	8.22	pEC50	6	nM	EC50	Bioorg. Med. Chem. Lett. (1999) 9: 1003-1008 [PMID:10230628]
ChEMBL	Agonistic activity against human androgen receptor (hAR) expressed in CV-1 cell lines	F	8.22	pEC50	6	nM	EC50	Bioorg. Med. Chem. Lett. (1999) 9: 1009-1012 [PMID:10230629]
ChEMBL	Agonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assay	F	8.24	pEC50	5.7	nM	EC50	Bioorg. Med. Chem. Lett. (2007) 17: 5442-5446 [PMID:17703938]
ChEMBL	Agonist activity at human androgen receptor in CV1 cells by transcriptional activation assay	F	8.24	pEC50	5.7	nM	EC50	Bioorg. Med. Chem. Lett. (2008) 18: 2967-2971 [PMID:18400499]
ChEMBL	Agonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assay	F	8.24	pEC50	5.7	nM	EC50	J. Med. Chem. (2007) 50: 2486-2496 [PMID:17439112]
ChEMBL	Agonist activity at human androgen receptor african green monkey CV1 cells by cotransfection assay	F	8.29	pEC50	5.1	nM	EC50	Bioorg. Med. Chem. Lett. (2008) 18: 3431-3435 [PMID:18442912]
ChEMBL	Agonist activity at human androgen receptor in CV1 cells measured as stimulation of luciferase reporter gene activity by cotransfection assay	F	8.29	pEC50	5.1	nM	EC50	J. Med. Chem. (2006) 49: 6143-6146 [PMID:17034117]
ChEMBL	Agonist activity at human androgen receptor expressed in CV1 cells	F	8.29	pEC50	5.1	nM	EC50	Bioorg. Med. Chem. Lett. (2007) 17: 1523-1526 [PMID:17257838]
ChEMBL	Agonist activity at human androgen receptor by luciferase reporter gene assay	F	8.29	pEC50	5.1	nM	EC50	J. Med. Chem. (2007) 50: 5049-5052 [PMID:17887661]
ChEMBL	Agonist activity at human AR	F	8.29	pEC50	5.1	nM	EC50	Bioorg. Med. Chem. Lett. (2007) 17: 1527-1531 [PMID:17267219]
ChEMBL	Agonist activity against Human Androgen receptor expressed in CV-1 cells	F	8.3	pEC50	5	nM	EC50	J. Med. Chem. (1999) 42: 210-212 [PMID:9925725]
ChEMBL	Agonist activity at human AR expressed in African green monkey COS7 cells after 24 hrs by luciferase reporter gene assay	B	8.52	pEC50	3	nM	EC50	Bioorg Med Chem (2017) 25: 3330-3349 [PMID:28454849]
ChEMBL	Agonist activity at androgen receptor in human MDA-MB-453 cells transfected with MMTV-LUC assessed as induction of MMTV-LTR/promoter linked LUC gene by luciferase transactivation assay	F	8.7	pEC50	2	nM	EC50	J. Med. Chem. (2009) 52: 4578-4581 [PMID:19606870]
ChEMBL	Agonist activity at human androgen receptor expressed in HEK293 cells by luciferase reporter gene assay	B	9.74	pEC50	0.18	nM	EC50	Bioorg. Med. Chem. Lett. (2014) 24: 5265-5267 [PMID:25305688]
ChEMBL	Agonist activity at human androgen receptor expressed in mouse C2C12 cells by androgen-specific response element-driven luciferase reporter gene assay	B	9.89	pEC50	0.13	nM	EC50	J. Med. Chem. (2014) 57: 7396-7411 [PMID:25121964]
ChEMBL	Agonist activity at androgen receptor expressed in mouse C2C12 cells assessed as osteoblast differentiation after 5 days	F	10.3	pEC50	0.05	nM	EC50	ACS Med. Chem. Lett. (2011) 2: 124-129 [PMID:24900290]
Androgen receptor/Androgen Receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3056] [GtoPdb: 628] [UniProtKB: P19091]
ChEMBL	Displacement of [3H] ]5alpha-DHT from mouse androgen receptor expressed in monkey COS7 cells after 2 hrs by scintillation counting analysis	B	9	pIC50	1	nM	IC50	J. Med. Chem. (2013) 56: 3414-3418 [PMID:23527816]
ChEMBL	Agonist activity at androgen receptor in mouse NIH3T3 cells transiently transfected with beta-galactosidase reporter gene assessed as cellular transformation by R-SAT assay	F	8.4	pEC50	3.98	nM	EC50	J. Med. Chem. (2009) 52: 7186-7191 [PMID:19856921]
Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
ChEMBL	DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone)	B	8.81	pKi	1.54	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibitory constant against rat prostate cytosol androgen receptor using [3H]mibolerone	B	9.16	pKi	0.69	nM	Ki	J. Med. Chem. (2000) 43: 3344-3347 [PMID:10966753]
ChEMBL	Inhibition of [3H]mibolerone binding to cytosolic androgen receptor of rat ventral prostate	B	9.55	pKi	0.28	nM	Ki	J. Med. Chem. (2005) 48: 917-925 [PMID:15715462]
ChEMBL	Binding affinity to rat androgen receptor by competitive inhibition assay	B	9.57	pKi	0.27	nM	Ki	Bioorg. Med. Chem. Lett. (2008) 18: 5567-5570 [PMID:18805694]
ChEMBL	Ability to inhibit binding of [3H]R-1881 to rat ventral prostate cytosolic androgen receptor was measured in a radioligand binding assay.	B	5.49	pIC50	3200	nM	IC50	J. Med. Chem. (2000) 43: 4629-4635 [PMID:11101354]
ChEMBL	Displacement of androgen fluormone from rat androgen receptor	B	7.73	pIC50	18.5	nM	IC50	J. Med. Chem. (2006) 49: 7366-7372 [PMID:17149866]
ChEMBL	Displacement of [3H]testosterone from Sprague-Dawley rat AR by liquid scintillation counting	B	8.51	pIC50	3.1	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 1744-1747 [PMID:21349712]
ChEMBL	Competitive binding affinity to rat androgen receptor	B	8.51	pIC50	3.1	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 6310-6313 [PMID:21944856]
ChEMBL	DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone)	B	8.64	pIC50	2.31	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)	B	8.65	pIC50	2.24	nM	IC50	J. Med. Chem. (2005) 48: 5666-5674 [PMID:16134935]
GtoPdb	-	-	8.65	pIC50	-	-	-	Chem Res Toxicol (2003) 16: 1338-58 [PMID:14565775]
ChEMBL	In vitro antagonist activity against rat prostatic androgen receptor (AR)	F	8.66	pIC50	2.2	nM	IC50	J. Med. Chem. (1986) 29: 2298-2315 [PMID:3783591]
ChEMBL	Displacement of [3H]testosterone from androgen receptor in Sprague-Dawley rat prostate gland after 2 hrs by liquid scintillation counting	B	8.7	pIC50	2	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 6310-6313 [PMID:21944856]
ChEMBL	Displacement of [3H]-MIB from wild-type rat AR LBD measured after 16 hrs by scintillation counting method	B	9	pIC50	1	nM	IC50	J Med Chem (2020) 63: 12642-12665 [PMID:33095584]
ChEMBL	Agonist activity at rat AR transfected in mouse C2C12 cells by luciferase reporter transactivation assay	F	8.55	pEC50	2.8	nM	EC50	J. Med. Chem. (2006) 49: 7596-7599 [PMID:17181141]
ChEMBL	Agonist activity at rat androgen receptor	F	9.01	pEC50	0.97	nM	EC50	Bioorg. Med. Chem. Lett. (2011) 21: 6310-6313 [PMID:21944856]
Corticosteroid binding globulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2421] [UniProtKB: P08185]
ChEMBL	In silico binding affinity to human corticosteriod binding globulin	B	4.92	pKd	4.92	-	-Log Kdiss	J. Med. Chem. (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL	Binding affinity to human CBG receptor (corticosteroid-binding globulins)	B	5.92	pKi	1202.26	nM	Ki	J. Med. Chem. (2004) 47: 2732-2742 [PMID:15139751]
CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511]
ChEMBL	Inactivation rate (Ki) for human placental Cytochrome P450 19A1	B	5.81	pKi	1550	nM	Ki	J. Med. Chem. (1989) 32: 651-658 [PMID:2918514]
ChEMBL	Competitive inhibition of binding to human placental Cytochrome P450 19A1	B	6.66	pKi	220	nM	Ki	J. Med. Chem. (1989) 32: 651-658 [PMID:2918514]
Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150]
ChEMBL	Binding affinity to GR (unknown origin)	B	6.27	pIC50	540	nM	IC50	Bioorg Med Chem (2017) 25: 3330-3349 [PMID:28454849]
Glucocorticoid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3368] [GtoPdb: 625] [UniProtKB: P06536]
ChEMBL	Displacement of [3H]dexamethasone from Sprague-Dawley rat GR by liquid scintillation counting	B	4.7	pIC50	20000	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 1744-1747 [PMID:21349712]
ChEMBL	Displacement of [3H]Dex from glucocorticoid receptor in Sprague-Dawley rat liver after 2 hrs by liquid scintillation counting	B	4.7	pIC50	20000	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 6310-6313 [PMID:21944856]
GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
ChEMBL	Agonist activity at human TGR5 expressed in CHO cells by luciferase assay	F	5.35	pEC50	4490	nM	EC50	J. Med. Chem. (2008) 51: 1831-1841 [PMID:18307294]
Mineralocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1994] [GtoPdb: 626] [UniProtKB: P08235]
ChEMBL	Binding affinity to MR (unknown origin)	B	6.44	pIC50	360	nM	IC50	Bioorg Med Chem (2017) 25: 3330-3349 [PMID:28454849]
Mineralocorticoid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3507] [GtoPdb: 626] [UniProtKB: P22199]
ChEMBL	Displacement of [3H]aldosterone from Sprague-Dawley rat MR by liquid scintillation counting	B	5.68	pIC50	2100	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 1744-1747 [PMID:21349712]
ChEMBL	Displacement of [3H]Aldo from mineralocorticoid receptor in Sprague-Dawley rat kidney after 2 hrs by liquid scintillation counting	B	5.68	pIC50	2100	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 6310-6313 [PMID:21944856]
Progesterone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401]
ChEMBL	Binding affinity to PR (unknown origin)	B	5.14	pIC50	7300	nM	IC50	Bioorg Med Chem (2017) 25: 3330-3349 [PMID:28454849]
ChEMBL	Agonist activity at PR (unknown origin) by luciferase reporter gene assay	B	5.09	pEC50	8200	nM	EC50	Bioorg Med Chem (2017) 25: 3330-3349 [PMID:28454849]
Progesterone receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1909044] [UniProtKB: Q690N0]
ChEMBL	DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)	B	6.79	pKi	163	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)	B	5.9	pIC50	1247	nM	IC50	DrugMatrix in vitro pharmacology data
Progesterone receptor in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3456] [UniProtKB: P06186]
ChEMBL	Displacement of [3H]progesterone from rabbit PR by liquid scintillation counting	B	6.36	pIC50	440	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 1744-1747 [PMID:21349712]
ChEMBL	Displacement of [3H]progesterone from progesterone receptor in JW rabbit uterus after 2 hrs by liquid scintillation counting	B	6.36	pIC50	440	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 6310-6313 [PMID:21944856]
Testis-specific androgen-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3305] [UniProtKB: P04278]
ChEMBL	Binding affinity towards human testosterone binding globulin.	B	8.74	pKd	8.74	-	-Log Kdiss	J. Med. Chem. (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL	Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin	B	9.74	pKd	0.18	nM	Kd	J. Med. Chem. (2008) 51: 2047-2056 [PMID:18330978]
ChEMBL	Inhibition of hSHBG (human sex hormone binding globulin )	F	8.42	pIC50	3.8	nM	IC50	J. Med. Chem. (1990) 33: 129-132 [PMID:2296011]
Testis-specific androgen-binding protein in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4932] [UniProtKB: P08689]
ChEMBL	Inhibition of rat androgen binding protein (rABP)	F	7.64	pIC50	23	nM	IC50	J. Med. Chem. (1990) 33: 129-132 [PMID:2296011]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]