teriparatide [Ligand Id: 4448] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL525610 ((1-34)-human parathyroid hormone, 1-34-human pth, Bonsity, Forsteo, Forteo, Human parathyroid hormone 1-34, LY 333334, LY-333334, LY333334, Pth (1-34), Teriparatide, Teriparatide rdna, Teriparatide sun, ZT-034) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| PTH1 receptor/Parathyroid hormone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1793] [GtoPdb: 331] [UniProtKB: Q03431] | ||||||||
| GtoPdb | - | - | 7.4 | pIC50 | - | - | - | J Biol Chem (1996) 271: 19888-93 [PMID:8702701] |
| ChEMBL | Displacement of 125I-PTH (1 to 15 residues) from human PTHR1 expressed in African green monkey COS7 cell membranes at 300 uM after 90 mins by gamma counting analysis | B | 10.1 | pIC50 | 0.08 | nM | IC50 | J Med Chem (2018) 61: 5949-5962 [PMID:29932656] |
| ChEMBL | Agonist activity at human PTHR1 expressed in HKRKB7 cells assessed as accumulation of intracellular cAMP after 20 mins by enzyme immunoassay | F | 8.6 | pEC50 | 2.5 | nM | EC50 | J Med Chem (2018) 61: 5949-5962 [PMID:29932656] |
| ChEMBL | Agonist activity at PTH1R overexpressed in HEK293 cells assessed as intracellular cAMP mobilization | F | 9 | pEC50 | 1 | nM | EC50 | J Med Chem (2010) 53: 4332-4353 [PMID:20218623] |
| ChEMBL | Agonist activity at PTH1R overexpressed in HEK293 cells assessed as intracellular cAMP production | F | 9.52 | pEC50 | 0.3 | nM | EC50 | J Med Chem (2010) 53: 4332-4353 [PMID:20218623] |
| PTH1 receptor in Rat [GtoPdb: 331] [UniProtKB: P25961] | ||||||||
| GtoPdb | - | - | 8.7 | pIC50 | - | - | - | J Biol Chem (1995) 270: 6584-8 [PMID:7896796] |
| PTH2 receptor in Human [GtoPdb: 332] [UniProtKB: P49190] | ||||||||
| GtoPdb | - | - | 7.8 | pIC50 | - | - | - |
J Biol Chem (1996) 271: 19888-93 [PMID:8702701]; J Pharmacol Exp Ther (2001) 299: 678-90 [PMID:11602681] |
| PTH2 receptor in Rat [GtoPdb: 332] [UniProtKB: P70555] | ||||||||
| GtoPdb | - | - | 6.3 | pIC50 | - | - | - | J Pharmacol Exp Ther (2001) 299: 678-90 [PMID:11602681] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
