teriparatide [Ligand Id: 4448] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL525610 ((1-34)-human parathyroid hormone, 1-34-human pth, Bonsity, Forsteo, Forteo, Human parathyroid hormone 1-34, LY333334, LY 333334, LY-333334, Pth (1-34), Teriparatide, Teriparatide rdna, Teriparatide recombinant human, ZT-034)
  • PTH1 receptor/Parathyroid hormone receptor in Human [ChEMBL: CHEMBL1793] [GtoPdb: 331] [UniProtKB: Q03431]
  • PTH1 receptor in Rat [GtoPdb: 331] [UniProtKB: P25961]
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  • PTH2 receptor in Human [GtoPdb: 332] [UniProtKB: P49190]
  • PTH2 receptor in Rat [GtoPdb: 332] [UniProtKB: P70555]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
PTH1 receptor/Parathyroid hormone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1793] [GtoPdb: 331] [UniProtKB: Q03431]
GtoPdb - - 7.4 pIC50 - - - J Biol Chem (1996) 271: 19888-93 [PMID:8702701]
ChEMBL Displacement of 125I-PTH (1 to 15 residues) from human PTHR1 expressed in African green monkey COS7 cell membranes at 300 uM after 90 mins by gamma counting analysis B 10.1 pIC50 0.08 nM IC50 J Med Chem (2018) 61: 5949-5962 [PMID:29932656]
ChEMBL Agonist activity at human PTHR1 expressed in HKRKB7 cells assessed as accumulation of intracellular cAMP after 20 mins by enzyme immunoassay F 8.6 pEC50 2.5 nM EC50 J Med Chem (2018) 61: 5949-5962 [PMID:29932656]
ChEMBL Agonist activity at PTH1R overexpressed in HEK293 cells assessed as intracellular cAMP mobilization F 9 pEC50 1 nM EC50 J. Med. Chem. (2010) 53: 4332-4353 [PMID:20218623]
ChEMBL Agonist activity at PTH1R overexpressed in HEK293 cells assessed as intracellular cAMP production F 9.52 pEC50 0.3 nM EC50 J. Med. Chem. (2010) 53: 4332-4353 [PMID:20218623]
PTH1 receptor in Rat [GtoPdb: 331] [UniProtKB: P25961]
GtoPdb - - 8.7 pIC50 - - - J Biol Chem (1995) 270: 6584-8 [PMID:7896796]
PTH2 receptor in Human [GtoPdb: 332] [UniProtKB: P49190]
GtoPdb - - 7.8 pIC50 - - - J Biol Chem (1996) 271: 19888-93 [PMID:8702701];
J Pharmacol Exp Ther (2001) 299: 678-90 [PMID:11602681]
PTH2 receptor in Rat [GtoPdb: 332] [UniProtKB: P70555]
GtoPdb - - 6.3 pIC50 - - - J Pharmacol Exp Ther (2001) 299: 678-90 [PMID:11602681]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]