Ligand id: 4448

Name: teriparatide

Compound class Peptide or derivative
Approved drug? Yes (FDA (1987), EMA (2003))
International Nonproprietary Names
INN number INN
5411 teriparatide
Forsteo® | Forteo® | PTH-(1-34) (human)
Teriparatide is a synthetic peptide of amino acids 1-34 of the N-terminal of human parathyroid hormone (PTH). The PubChem and ChEMBL entries linked to above both display a chemical structure for teriparatide. Compare this to the clinical candidate peptide abaloparatide which is a synthetic analogue of human parathyroid hormone-related protein (PTHrP) [1].

Teriparatide biosimilars and non-originator biologicals are available in countries where patents have already expired. The patents on the reference agent Forteo/Forsteo expire in the US and in Europe in August 2019. The table below lists teriparatide biosimilars that are already approved or are in development.

Product nameCompanyClinical phaseReference
teriparatide similar biologicIntas PharmaceuticalsApproved (India 2010)[5]
teriparatide similar biologicCadila Healthcare Approved (India 2012)[5]
teriparatide similar biologicUSVApproved (India 2012)[5]
TerrosaGedeon RichterApproved (EMA 2017)[3-4]
MovymiaSTADA Arzneimittel AGApproved (EMA 2017)[2]
Bonsity (PF708)PfenexApproved (FDA 2019)[4]
Database Links
CAS Registry No. 52232-67-4 (source: Scifinder)
ChEMBL Ligand CHEMBL525610
DrugBank Ligand DB06285
GtoPdb PubChem SID 135652417
PubChem CID 16132393
Search PubMed clinical trials teriparatide
Search PubMed titles teriparatide
Search PubMed titles/abstracts teriparatide
Wikipedia Teriparatide

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