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|Compound class||Peptide or derivative|
|Approved drug?||Yes (FDA (1987), EMA (2003))|
|International Nonproprietary Names|
|Forsteo® | Forteo® | PTH-(1-34) (human)|
|Teriparatide is a synthetic peptide of amino acids 1-34 of the N-terminal of human parathyroid hormone (PTH). The PubChem and ChEMBL entries linked to above both display a chemical structure for teriparatide. Compare this to the clinical candidate peptide abaloparatide which is a synthetic analogue of human parathyroid hormone-related protein (PTHrP) .
Teriparatide biosimilars and non-originator biologicals are available in countries where patents have already expired. The patents on the reference agent Forteo/Forsteo expire in the US and in Europe in August 2019. The table below lists teriparatide biosimilars that are already approved or are in development.
|CAS Registry No.||52232-67-4 (source: Scifinder)|
|GtoPdb PubChem SID||135652417|
|Search PubMed clinical trials||teriparatide|
|Search PubMed titles||teriparatide|
|Search PubMed titles/abstracts||teriparatide|
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Parathyroid hormone (1-34) (human)
Cat. No. 3011