NSC 157449 [Ligand Id: 834] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL280711 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CXCR1/Interleukin-8 receptor A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4029] [GtoPdb: 68] [UniProtKB: P25024] | ||||||||
| ChEMBL | Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 1 expressed in CHO Cells using [125I]IL-8 radioligand | B | 4.74 | pIC50 | 18200 | nM | IC50 | J Med Chem (2004) 47: 1319-1321 [PMID:14998320] |
| ChEMBL | Displacement of [125I]IL-8 from CXCR1 (unknown origin) stably expressed in CHO cells | B | 4.74 | pIC50 | 18200 | nM | IC50 | Eur J Med Chem (2020) 185: 111853-111853 [PMID:31732253] |
| CXCR2/Interleukin-8 receptor B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2434] [GtoPdb: 69] [UniProtKB: P25025] | ||||||||
| GtoPdb | - | - | 6.3 | pIC50 | - | - | - | J Biol Chem (1998) 273: 10095-8 [PMID:9553055] |
| ChEMBL | Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 2 expressed in CHO Cells using [125I]IL-8 radioligand | B | 6.49 | pIC50 | 320 | nM | IC50 | J Med Chem (2004) 47: 1319-1321 [PMID:14998320] |
| ChEMBL | Displacement of [125I]IL8 from human recombinant CXCR2 expressed in CHO cells | B | 6.49 | pIC50 | 320 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 1713-1717 [PMID:17236763] |
| ChEMBL | Displacement of [125I]IL-8 from CXCR2 (unknown origin) stably expressed in CHO cells | B | 6.49 | pIC50 | 320 | nM | IC50 | Eur J Med Chem (2020) 185: 111853-111853 [PMID:31732253] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
