dapsone [Ligand Id: 10934] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1043 (Aczone, Dapsone, Dapsonum, Diaminodiphenylsulfone, Diaphenylsulfone, J04BA02, Novophone, NSC-6091, NSC-6091D, Servidapson) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Dihydrofolate reductase in Pneumocystis carinii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1926] [UniProtKB: P16184] | ||||||||
| ChEMBL | Inhibitory activity was determined against dihydrofolate reductase in Pneumocystis carinii. | B | 5.82 | pIC50 | 1500 | nM | IC50 | J Med Chem (1995) 38: 4739-4759 [PMID:7490723] |
| Dihydropteroate synthetase, putative in Plasmodium berghei str. ANKA (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1741265] [UniProtKB: A0A113T0T6] | ||||||||
| ChEMBL | Inhibitory activity against dihydropteroic acid synthase (SYN) from Plasmodium berghei | B | 4.91 | pIC50 | 12410 | nM | IC50 | J Med Chem (2004) 47: 240-253 [PMID:14695838] |
| myeloperoxidase/Myeloperoxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164] | ||||||||
| ChEMBL | Inhibition of MPO (unknown origin) | B | 6.38 | pIC50 | 420 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1-7 [PMID:30466896] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimicrobial activity against Plasmodium falciparum | F | 4.74 | pIC50 | 18000 | nM | IC50 | Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316] |
| Plasmodium vivax (target type: ORGANISM) [ChEMBL: CHEMBL613013] | ||||||||
| ChEMBL | Antimalarial activity against Plasmodium vivax infected in human blood incubated for 24 to 36 hrs | F | 5.79 | pIC50 | 1625 | nM | IC50 | Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292] |
| 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] | ||||||||
| ChEMBL | Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 mins | F | 6.74 | pKi | 183 | nM | Ki | Bioorg Med Chem (2013) 21: 4614-4627 [PMID:23787290] |
| Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum [GtoPdb: 3065] | ||||||||
| GtoPdb | Enzyme inhibition assay. | - | 5.22 | pKi | 6000 | nM | Ki | Antimicrob Agents Chemother (1991) 35: 267-71 [PMID:2024960] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
