SM-130,686 [Ligand Id: 5866] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL360227 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ghrelin receptor/Ghrelin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4616] [GtoPdb: 246] [UniProtKB: Q92847] | ||||||||
| ChEMBL | Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation | B | 8.68 | pIC50 | 2.1 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1789-1792 [PMID:15780607] |
| GtoPdb | - | - | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (2001) 44: 4641-9 [PMID:11741481] |
| ChEMBL | Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin | B | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (2004) 47: 4286-4290 [PMID:15294000] |
| GtoPdb | - | - | 9.51 | pEC50 | 0.31 | nM | EC50 | Mol Pharmacol (2009) 75: 44-59 [PMID:18923064] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
