L-NAME [Ligand Id: 5213] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL7890 (L-name, Ng-nitro-l-arginine methyl ester) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] | ||||||||
| ChEMBL | Inhibitory concentration against recombinant human (neuronal nitric oxide synthase) n-NOS | B | 5.8 | pIC50 | 1600 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 1981-1984 [PMID:12781178] |
| ChEMBL | Concentration required to inhibit neuronal nitric oxide synthase | B | 5.8 | pIC50 | 1600 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 2561-2564 [PMID:12182860] |
| ChEMBL | Inhibitory activity against human neuronal nitric oxide synthase | B | 6.82 | pIC50 | 150 | nM | IC50 | J Med Chem (2003) 46: 913-916 [PMID:12620067] |
| Neuronal NOS/Nitric-oxide synthase, brain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476] | ||||||||
| ChEMBL | Inhibition of conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by neuronal NOS (n NOS) from rat cerebellum | F | 6.82 | pIC50 | 150 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1023-1026 [PMID:11327580] |
| Endothelial NOS/Nitric-oxide synthase, endothelial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474] | ||||||||
| ChEMBL | Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells | F | 5.57 | pIC50 | 2700 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1023-1026 [PMID:11327580] |
| ChEMBL | Inhibitory activity against human endothelial nitric oxide synthase | B | 5.57 | pIC50 | 2700 | nM | IC50 | J Med Chem (2003) 46: 913-916 [PMID:12620067] |
| ChEMBL | Inhibitory concentration against recombinant human Endothelial nitric oxide synthase | B | 5.82 | pIC50 | 1500 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 1981-1984 [PMID:12781178] |
| ChEMBL | In vitro inhibition of endothelial nitric oxide synthase. | B | 5.82 | pIC50 | 1500 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 2561-2564 [PMID:12182860] |
| Nitric-oxide synthase, endothelial in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4802] [UniProtKB: P29473] | ||||||||
| ChEMBL | Compound was tested for its inhibitory activity against endothelial NO2- synthesis | B | 4 | pIC50 | 100000 | nM | IC50 | J Med Chem (1994) 37: 1899-1907 [PMID:7518001] |
| Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] | ||||||||
| ChEMBL | Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells | F | 4.85 | pIC50 | 14000 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1023-1026 [PMID:11327580] |
| ChEMBL | Inhibitory activity of compound against human inducible nitric oxide synthase | B | 4.85 | pIC50 | 14000 | nM | IC50 | J Med Chem (2003) 46: 913-916 [PMID:12620067] |
| ChEMBL | Inhibitory concentration against human Inducible nitric oxide synthase | B | 5.1 | pIC50 | 8000 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 1981-1984 [PMID:12781178] |
| ChEMBL | In vitro inhibition of inducible nitric oxide synthase. | B | 5.1 | pIC50 | 8000 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 2561-2564 [PMID:12182860] |
| Inducible NOS/Nitric oxide synthase, inducible in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477] | ||||||||
| ChEMBL | Inhibition of iNOS-mediated NO production in LPS-induced mouse BV2 cells | B | 4.59 | pIC50 | 25800 | nM | IC50 | Bioorg Med Chem (2008) 16: 9867-9870 [PMID:18926710] |
| ChEMBL | Inhibition of iNOS in mouse BV2 microglial cells assessed as NO production | B | 4.59 | pIC50 | 25800 | nM | IC50 | Bioorg Med Chem (2011) 19: 677-683 [PMID:21115251] |
| ChEMBL | Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse BV2 cells measured after 24 hrs of post-stimulation by Griess reaction method | B | 4.87 | pIC50 | 13350 | nM | IC50 | Eur J Med Chem (2012) 47: 97-103 [PMID:22115618] |
| ChEMBL | Compound was tested for its inhibitory activity against macrophage NO2- synthesis | B | 5.59 | pIC50 | 2600 | nM | IC50 | J Med Chem (1994) 37: 1899-1907 [PMID:7518001] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
