L-NAME [Ligand Id: 5213] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL7890 (L-name, Ng-nitro-l-arginine methyl ester) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] | ||||||||
| ChEMBL | Inhibitory concentration against recombinant human (neuronal nitric oxide synthase) n-NOS | B | 5.8 | pIC50 | 1600 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 1981-1984 [PMID:12781178] |
| ChEMBL | Concentration required to inhibit neuronal nitric oxide synthase | B | 5.8 | pIC50 | 1600 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 2561-2564 [PMID:12182860] |
| ChEMBL | Inhibitory activity against human neuronal nitric oxide synthase | B | 6.82 | pIC50 | 150 | nM | IC50 | J Med Chem (2003) 46: 913-916 [PMID:12620067] |
| Neuronal NOS/Nitric-oxide synthase, brain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476] | ||||||||
| ChEMBL | Inhibition of rat brain nNOS expressed in baculovirus-infected Sf9 cells Escherichia coli assessed as reduction of [3H]-arginine to [3H]-citrulline conversion | B | 4.15 | pIC50 | 70000 | nM | IC50 | Bioorg Med Chem (2022) 72: 116970-116970 [PMID:36063653] |
| ChEMBL | Inhibition of conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by neuronal NOS (n NOS) from rat cerebellum | F | 6.82 | pIC50 | 150 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1023-1026 [PMID:11327580] |
| Endothelial NOS/Nitric-oxide synthase, endothelial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474] | ||||||||
| ChEMBL | Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells | F | 5.57 | pIC50 | 2700 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1023-1026 [PMID:11327580] |
| ChEMBL | Inhibitory activity against human endothelial nitric oxide synthase | B | 5.57 | pIC50 | 2700 | nM | IC50 | J Med Chem (2003) 46: 913-916 [PMID:12620067] |
| ChEMBL | Inhibitory concentration against recombinant human Endothelial nitric oxide synthase | B | 5.82 | pIC50 | 1500 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 1981-1984 [PMID:12781178] |
| ChEMBL | In vitro inhibition of endothelial nitric oxide synthase. | B | 5.82 | pIC50 | 1500 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 2561-2564 [PMID:12182860] |
| Nitric-oxide synthase, endothelial in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4802] [UniProtKB: P29473] | ||||||||
| ChEMBL | Compound was tested for its inhibitory activity against endothelial NO2- synthesis | B | 4 | pIC50 | 100000 | nM | IC50 | J Med Chem (1994) 37: 1899-1907 [PMID:7518001] |
| Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] | ||||||||
| ChEMBL | Inhibition of human iNOS assessed as inhibition constant | B | 4.15 | pKi | 70000 | nM | Ki | Bioorg Med Chem (2022) 72: 116970-116970 [PMID:36063653] |
| ChEMBL | Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells | F | 4.85 | pIC50 | 14000 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1023-1026 [PMID:11327580] |
| ChEMBL | Inhibitory activity of compound against human inducible nitric oxide synthase | B | 4.85 | pIC50 | 14000 | nM | IC50 | J Med Chem (2003) 46: 913-916 [PMID:12620067] |
| ChEMBL | Inhibition of iNOS (unknown origin) | B | 4.87 | pIC50 | 13500 | nM | IC50 | Eur J Med Chem (2023) 248: 115112-115112 [PMID:36641860] |
| ChEMBL | Inhibitory concentration against human Inducible nitric oxide synthase | B | 5.1 | pIC50 | 8000 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 1981-1984 [PMID:12781178] |
| ChEMBL | In vitro inhibition of inducible nitric oxide synthase. | B | 5.1 | pIC50 | 8000 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 2561-2564 [PMID:12182860] |
| Inducible NOS/Nitric oxide synthase, inducible in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477] | ||||||||
| ChEMBL | Inhibition of iNOS-mediated NO production in LPS-induced mouse BV2 cells | B | 4.59 | pIC50 | 25800 | nM | IC50 | Bioorg Med Chem (2008) 16: 9867-9870 [PMID:18926710] |
| ChEMBL | Inhibition of iNOS in mouse BV2 microglial cells assessed as NO production | B | 4.59 | pIC50 | 25800 | nM | IC50 | Bioorg Med Chem (2011) 19: 677-683 [PMID:21115251] |
| ChEMBL | Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse BV2 cells measured after 24 hrs of post-stimulation by Griess reaction method | B | 4.87 | pIC50 | 13350 | nM | IC50 | Eur J Med Chem (2012) 47: 97-103 [PMID:22115618] |
| ChEMBL | Compound was tested for its inhibitory activity against macrophage NO2- synthesis | B | 5.59 | pIC50 | 2600 | nM | IC50 | J Med Chem (1994) 37: 1899-1907 [PMID:7518001] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
