L-NAME [Ligand Id: 5213] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL7890 (L-name)
  • Neuronal NOS/Nitric-oxide synthase, brain in Human [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475]
  • Neuronal NOS/Nitric-oxide synthase, brain in Rat [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476]
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  • Endothelial NOS/Nitric-oxide synthase, endothelial in Human [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474]
  • Nitric-oxide synthase, endothelial in Bovine [ChEMBL: CHEMBL4802] [UniProtKB: P29473]
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  • Inducible NOS/Nitric oxide synthase, inducible in Human [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228]
  • Inducible NOS/Nitric oxide synthase, inducible in Mouse [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475]
ChEMBL Inhibitory concentration against recombinant human (neuronal nitric oxide synthase) n-NOS B 5.8 pIC50 1600 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 1981-1984 [PMID:12781178]
ChEMBL Concentration required to inhibit neuronal nitric oxide synthase B 5.8 pIC50 1600 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 2561-2564 [PMID:12182860]
ChEMBL Inhibitory activity against human neuronal nitric oxide synthase B 6.82 pIC50 150 nM IC50 J. Med. Chem. (2003) 46: 913-916 [PMID:12620067]
Neuronal NOS/Nitric-oxide synthase, brain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476]
ChEMBL Inhibition of conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by neuronal NOS (n NOS) from rat cerebellum F 6.82 pIC50 150 nM IC50 Bioorg. Med. Chem. Lett. (2001) 11: 1023-1026 [PMID:11327580]
Endothelial NOS/Nitric-oxide synthase, endothelial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474]
ChEMBL Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells F 5.57 pIC50 2700 nM IC50 Bioorg. Med. Chem. Lett. (2001) 11: 1023-1026 [PMID:11327580]
ChEMBL Inhibitory activity against human endothelial nitric oxide synthase B 5.57 pIC50 2700 nM IC50 J. Med. Chem. (2003) 46: 913-916 [PMID:12620067]
ChEMBL Inhibitory concentration against recombinant human Endothelial nitric oxide synthase B 5.82 pIC50 1500 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 1981-1984 [PMID:12781178]
ChEMBL In vitro inhibition of endothelial nitric oxide synthase. B 5.82 pIC50 1500 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 2561-2564 [PMID:12182860]
Nitric-oxide synthase, endothelial in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4802] [UniProtKB: P29473]
ChEMBL Compound was tested for its inhibitory activity against endothelial NO2- synthesis B 4 pIC50 100000 nM IC50 J. Med. Chem. (1994) 37: 1899-1907 [PMID:7518001]
Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228]
ChEMBL Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells F 4.85 pIC50 14000 nM IC50 Bioorg. Med. Chem. Lett. (2001) 11: 1023-1026 [PMID:11327580]
ChEMBL Inhibitory activity of compound against human inducible nitric oxide synthase B 4.85 pIC50 14000 nM IC50 J. Med. Chem. (2003) 46: 913-916 [PMID:12620067]
ChEMBL Inhibitory concentration against human Inducible nitric oxide synthase B 5.1 pIC50 8000 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 1981-1984 [PMID:12781178]
ChEMBL In vitro inhibition of inducible nitric oxide synthase. B 5.1 pIC50 8000 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 2561-2564 [PMID:12182860]
Inducible NOS/Nitric oxide synthase, inducible in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477]
ChEMBL Inhibition of iNOS-mediated NO production in LPS-induced mouse BV2 cells B 4.59 pIC50 25800 nM IC50 Bioorg. Med. Chem. (2008) 16: 9867-9870 [PMID:18926710]
ChEMBL Inhibition of iNOS in mouse BV2 microglial cells assessed as NO production B 4.59 pIC50 25800 nM IC50 Bioorg. Med. Chem. (2011) 19: 677-683 [PMID:21115251]
ChEMBL Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse BV2 cells measured after 24 hrs of post-stimulation by Griess reaction method B 4.87 pIC50 13350 nM IC50 Eur. J. Med. Chem. (2012) 47: 97-103 [PMID:22115618]
ChEMBL Compound was tested for its inhibitory activity against macrophage NO2- synthesis B 5.59 pIC50 2600 nM IC50 J. Med. Chem. (1994) 37: 1899-1907 [PMID:7518001]

ChEMBL data shown on this page come from version 26:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]