Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1203	7q36.1	NOS3	nitric oxide synthase 3
Mouse	-	1202	5 11.32 cM	Nos3	nitric oxide synthase 3, endothelial cell
Rat	-	1202		Nos3	nitric oxide synthase 3

Previous and Unofficial Names

endothelial nitric oxide synthase | EC-NOS | endothelial NOS | constitutive NOS | cNOS | Nitric oxide synthase 3 / NOSIII | nitric oxide synthase 3 (endothelial cell) | nitric oxide synthase 3

Database Links
BRENDA	1.14.13.39
CATH/Gene3D	3.40.50.360
ChEMBL Target	CHEMBL4803 (Hs), CHEMBL2643 (Mm), CHEMBL1075230 (Rn)
DrugBank Target	P29474 (Hs)
Ensembl Gene	ENSG00000164867 (Hs), ENSMUSG00000028978 (Mm), ENSRNOG00000009348 (Rn)
Entrez Gene	4846 (Hs), 18127 (Mm), 24600 (Rn)
Human Protein Atlas	ENSG00000164867 (Hs)
KEGG Enzyme	1.14.13.39
KEGG Gene	hsa:4846 (Hs), mmu:18127 (Mm), rno:24600 (Rn)
Pharos	P29474 (Hs)
UniProtKB	P29474 (Hs), P70313 (Mm), Q62600 (Rn)
Wikipedia	NOS3 (Hs)

Enzyme Reaction
EC Number: 1.14.13.39

Products
Product Species Reference NO Human L-citrulline Human

Cofactors
Cofactor Species Comments Reference Zn2+ Human NADPH Human heme Human flavin adenine dinucleotide Human flavin mononucleotide Human BH4 Human oxygen Human

Endogenous Substrate (Human)

L-arginine

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference L-NNA Hs Inhibition 7.5 pKi 1 ⤷ pKi 7.5 (Ki 3x10-8 M) [1] GW274150 Hs Inhibition 4.5 pIC50 2 ⤷ pIC50 4.5 (IC50 3.4x10-5 M) [2]

Immuno Process Associations

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 3 GO processes GO:0034097 response to cytokine IEP GO:0036017 response to erythropoietin IEP GO:0071356 cellular response to tumor necrosis factor IEP