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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 1203 | 7q36.1 | NOS3 | nitric oxide synthase 3 | |
Mouse | - | 1202 | 5 11.32 cM | Nos3 | nitric oxide synthase 3, endothelial cell | |
Rat | - | 1202 | Nos3 | nitric oxide synthase 3 |
Database Links ![]() |
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BRENDA | 1.14.13.39 |
CATH/Gene3D | 3.40.50.360 |
ChEMBL Target | CHEMBL4803 (Hs), CHEMBL2643 (Mm), CHEMBL1075230 (Rn) |
DrugBank Target | P29474 (Hs) |
Ensembl Gene | ENSG00000164867 (Hs), ENSMUSG00000028978 (Mm), ENSRNOG00000009348 (Rn) |
Entrez Gene | 4846 (Hs), 18127 (Mm), 24600 (Rn) |
Human Protein Atlas | ENSG00000164867 (Hs) |
KEGG Enzyme | 1.14.13.39 |
KEGG Gene | hsa:4846 (Hs), mmu:18127 (Mm), rno:24600 (Rn) |
Pharos | P29474 (Hs) |
UniProtKB | P29474 (Hs), P70313 (Mm), Q62600 (Rn) |
Wikipedia | NOS3 (Hs) |
Enzyme Reaction ![]() |
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Products ![]() |
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Cofactors ![]() |
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Endogenous Substrate (Human) |
L-arginine |
Download all structure-activity data for this target as a CSV file
Inhibitors | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | |||||||||||||||
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1. Collins JL, Shearer BG, Oplinger JA, Lee S, Garvey EP, Salter M, Duffy C, Burnette TC, Furfine ES. (1998) N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity. J. Med. Chem., 41 (15): 2858-71. [PMID:9667974]
2. Connolly S, Aberg A, Arvai A, Beaton HG, Cheshire DR, Cook AR, Cooper S, Cox D, Hamley P, Mallinder P et al.. (2004) 2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution. J. Med. Chem., 47 (12): 3320-3. [PMID:15163211]