ChEMBL ligand: CHEMBL98110
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21	B	7.46	pKi	34.76	nM	Ki	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
GtoPdb	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	-	7.46	pKi	34.76	nM	Ki	J Med Chem (2008) 51: 2187-95 [PMID:18327899]
GtoPdb	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	-	8.13	pKi	7.4	nM	Ki	J Med Chem (2008) 51: 2187-95 [PMID:18327899]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	B	8.13	pKi	7.4	nM	Ki	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
GtoPdb	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	-	6.76	pIC50	173.4	nM	IC50	J Med Chem (2008) 51: 2187-95 [PMID:18327899]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21	B	6.76	pIC50	173.4	nM	IC50	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL	Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3)	B	7.47	pIC50	34.2	nM	IC50	J Med Chem (2007) 50: 5967-5975 [PMID:17975902]
ChEMBL	Allosteric inhibition of human recombinant FPPS using GPP and [3H]IPP as substrate incubated with enzyme for 10 mins prior to substrate addition by liquid scintillation counting analysis	B	7.48	pIC50	33	nM	IC50	J Med Chem (2014) 57: 5764-5776 [PMID:24911527]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	B	7.49	pIC50	32.6	nM	IC50	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
GtoPdb	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	-	7.49	pIC50	32.6	nM	IC50	J Med Chem (2008) 51: 2187-95 [PMID:18327899]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]