dabigatran etexilate [Ligand Id: 6379] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL539697 (BIBR 1048, BIBR-1048, BIBR 1048 BS RS1, BIBR-1048-BS-RS1, Dabigatran etexilate, Dabigatran etexilate methanesulfonate, Dabigatran etexilato, Pradaxa) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] | ||||||||
| ChEMBL | Binding affinity to human thrombin | B | 8.35 | pKi | 4.5 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 2089-2092 [PMID:23466230] |
| ChEMBL | Inhibition of human thrombin preincubated for 10 mins using Ac-FVR-AMC as substrate by chromogenic assay | B | 8.58 | pIC50 | 2.63 | nM | IC50 | Bioorg Med Chem (2016) 24: 73-84 [PMID:26690913] |
| ChEMBL | Inhibition of human thrombin preincubated for 10 mins using Ac-FVR-AMC as substrate by chromogenic assay | B | 8.58 | pIC50 | 2.61 | nM | IC50 | Bioorg Med Chem (2016) 24: 73-84 [PMID:26690913] |
| Thrombin in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2040703] [UniProtKB: Q28731] | ||||||||
| ChEMBL | Inhibition of rabbit thrombin-induced platelet aggregation in rabbit platelet-rich plasma preincubated with rabbit liver microsomes for 4 hrs followed by addition to platelet | B | 6.26 | pIC50 | 554 | nM | IC50 | Bioorg Med Chem (2017) 25: 458-470 [PMID:27884512] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
