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Synonyms: BW-56-72 | BW-5672 | NSC-106568 | Primsol® | Proloprim® | Trimpex®
trimethoprim is an approved drug (FDA (1980))
Compound class: Synthetic organic
Comment: Trimethoprim is a synthetic diaminopyrimidine molecule with antibacterial and antiprotozoal activities. Mechanistically, it inhibits bacterial dihydrofolate reductase and disrupts the conversion of dihydrofolic acid to tetrahydrofolic acid which ultimately inhibits bacterial DNA synthesis. Sulfonamide drugs potentiate trimethoprim's activity.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Yes (FDA (1980))
|WHO Essential Medicine
|WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
|International Nonproprietary Names
|BW-56-72 | BW-5672 | NSC-106568 | Primsol® | Proloprim® | Trimpex®
|CAS Registry No.
|738-70-5 (source: PubChem)
|GtoPdb PubChem SID
|RCSB PDB Ligand
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|UniChem Connectivity Search for chemical match using the InChIKey