trimethoprim   Click here for help

GtoPdb Ligand ID: 10931

Synonyms: BW-56-72 | BW-5672 | NSC-106568 | Primsol® | Proloprim® | Trimpex®
Approved drug PDB Ligand
trimethoprim is an approved drug (FDA (1980))
Compound class: Synthetic organic
Comment: Trimethoprim is a synthetic diaminopyrimidine molecule with antibacterial and antiprotozoal activities. Mechanistically, it inhibits bacterial dihydrofolate reductase and disrupts the conversion of dihydrofolic acid to tetrahydrofolic acid which ultimately inhibits bacterial DNA synthesis. Sulfonamide drugs potentiate trimethoprim's activity.

trimethoprim is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 105.51
Molecular weight 290.14
XLogP 0.78
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES COc1cc(Cc2cnc(nc2N)N)cc(c1OC)OC
Isomeric SMILES COc1cc(Cc2cnc(nc2N)N)cc(c1OC)OC
InChI InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
InChI Key IEDVJHCEMCRBQM-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1980))
Approved drug? Yes. FDA (1980)
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
IUPAC Name Click here for help
5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
International Nonproprietary Names Click here for help
INN number INN
1047 trimethoprim
Synonyms Click here for help
BW-56-72 | BW-5672 | NSC-106568 | Primsol® | Proloprim® | Trimpex®
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Trimethoprim
Other databases
BindingDB Ligand 18069
CAS Registry No. 738-70-5 (source: PubChem)
ChEMBL Ligand CHEMBL22
DrugBank Ligand DB00440
DrugCentral Ligand 2755
GtoPdb PubChem SID 405560372
PubChem CID 5578
RCSB PDB Ligand TOP
Search Google for chemical match using the InChIKey IEDVJHCEMCRBQM-UHFFFAOYSA-N
Search Google for chemicals with the same backbone IEDVJHCEMCRBQM
Search PubMed clinical trials trimethoprim
Search PubMed titles trimethoprim
Search PubMed titles/abstracts trimethoprim
UniChem Compound Search for chemical match using the InChIKey IEDVJHCEMCRBQM-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey IEDVJHCEMCRBQM-UHFFFAOYSA-N

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MedChemExpress
Trimethoprim (links to external site)
Cat. No. HY-B0510
Trimethoprim (Standard) (links to external site)
Cat. No. HY-B0510R