ChEMBL ligand: CHEMBL223228 (DMP-266, (-)-efavirenz, Efavirenz, Efavirenz teva, Efavirenzum, L-743726, NSC-742403, Stocrin, Sustiva, Sustiva 600, Viraday)
CYP46A1/Cholesterol 24-hydroxylase in Human [ChEMBL: CHEMBL4523510] [GtoPdb: 1373] [UniProtKB: Q9Y6A2] There should be some charts here, you may need to enable JavaScript!
Envelope glycoprotein gp160 in Human immunodeficiency virus 1 [ChEMBL: CHEMBL1293311] [UniProtKB: Q6QLK5] There should be some charts here, you may need to enable JavaScript!
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856] There should be some charts here, you may need to enable JavaScript!
Reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL2366516] [UniProtKB: Q9WKE8] There should be some charts here, you may need to enable JavaScript!
CYP3A4 in Human [GtoPdb: 1337] [UniProtKB: P08684] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CYP46A1/Cholesterol 24-hydroxylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523510] [GtoPdb: 1373] [UniProtKB: Q9Y6A2]
ChEMBL	Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by UV-spectrophotometric method	B	4.99	pKd	10200	nM	Kd	J Med Chem (2020) 63: 6477-6488 [PMID:31617715]
ChEMBL	Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate at 24 degC by stopped-flow spectrophotometric method	B	5.3	pKd	5000	nM	Kd	J Med Chem (2020) 63: 6477-6488 [PMID:31617715]
ChEMBL	Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by UV-spectrophotometric method	B	6.1	pKd	800	nM	Kd	J Med Chem (2020) 63: 6477-6488 [PMID:31617715]
Envelope glycoprotein gp160 in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293311] [UniProtKB: Q6QLK5]
ChEMBL	Binding affinity to HIV1 cYTA48P envelope glycoprotein gp120 infected in human TZM-b1 cells assessed as induction of conformational changes measured after 48 hrs	B	8.46	pIC50	3.5	nM	IC50	Bioorg Med Chem Lett (2019) 29: 719-723 [PMID:30665681]
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
ChEMBL	Inhibition of HIV1 reverse transcriptase K103N mutant	B	5.52	pKi	3000	nM	Ki	J Med Chem (2007) 50: 5412-5424 [PMID:17910429]
ChEMBL	Inhibition of HIV1 recombinant reverse transcriptase K103N mutant-DNA binary complex expressed in Escherichia coli BL21	B	5.8	pKi	1600	nM	Ki	J Med Chem (2009) 52: 840-851 [PMID:19140683]
ChEMBL	Inhibition of HIV1 recombinant free reverse transcriptase K103N mutant expressed in Escherichia coli BL21	B	5.82	pKi	1500	nM	Ki	J Med Chem (2009) 52: 840-851 [PMID:19140683]
ChEMBL	Inhibition of DNA-dependent DNA polymerase activity of HIV1 reverse transcriptase p66/p66 homodimer K103N mutant using activated DNA and [alpha-32P]dATP after 30 mins by liquid scintillation counting	B	6.14	pKi	730	nM	Ki	Bioorg Med Chem (2011) 19: 5794-5802 [PMID:21903401]
ChEMBL	Inhibition of DNA-dependent DNA polymerase activity of HIV1 reverse transcriptase p66/p66 homodimer K103N/Y181C mutant using activated DNA and [alpha-32P]dATP after 30 mins by liquid scintillation counting	B	6.24	pKi	580	nM	Ki	Bioorg Med Chem (2011) 19: 5794-5802 [PMID:21903401]
ChEMBL	Inhibition of HIV1 reverse transcriptase p66/p51 K103N mutant after 30 mins by liquid scintillation counting	B	6.24	pKi	580	nM	Ki	Bioorg Med Chem (2013) 21: 1150-1158 [PMID:23357038]
ChEMBL	Inhibition of HIV-1 Mutant HIV-1 RT enzymes containing the single amino acid substitution Y188L	B	6.52	pKi	300	nM	Ki	J Med Chem (2001) 44: 305-315 [PMID:11462972]
ChEMBL	Inhibition of HIV1 recombinant reverse transcriptase K103N mutant-DNA-dNTP ternary complex expressed in Escherichia coli BL21	B	6.7	pKi	200	nM	Ki	J Med Chem (2009) 52: 840-851 [PMID:19140683]
ChEMBL	Inhibition of HIV-1 Mutant HIV-1 RT enzymes containing the single amino acid substitution K103N	B	6.8	pKi	160	nM	Ki	J Med Chem (2001) 44: 305-315 [PMID:11462972]
ChEMBL	Inhibition of RNA dependent DNA polymerase activity of HIV1 recombinant reverse transcriptase p66/p51 K103N mutant expressed in Escherichia coli JM109	B	6.8	pKi	160	nM	Ki	J Med Chem (2009) 52: 1224-1228 [PMID:19170521]
ChEMBL	Inhibition of RNA dependent DNA polymerase activity of HIV1 recombinant reverse transcriptase p66/p51 Y181I mutant expressed in Escherichia coli JM109	B	6.82	pKi	150	nM	Ki	J Med Chem (2009) 52: 1224-1228 [PMID:19170521]
ChEMBL	Inhibition of HIV-1 Mutant HIV-1 RT enzymes containing the single amino acid substitution Y181I	B	6.82	pKi	150	nM	Ki	J Med Chem (2001) 44: 305-315 [PMID:11462972]
ChEMBL	Inhibition of HIV1 reverse transcriptase p66/p51 K103N/Y181C mutant after 30 mins by liquid scintillation counting	B	6.85	pKi	140	nM	Ki	Bioorg Med Chem (2013) 21: 1150-1158 [PMID:23357038]
ChEMBL	Inhibition of RNA dependent DNA polymerase activity of HIV1 recombinant reverse transcriptase p66/p51 L100I mutant expressed in Escherichia coli JM109	B	6.92	pKi	120	nM	Ki	J Med Chem (2009) 52: 1224-1228 [PMID:19170521]
ChEMBL	Inhibition of HIV-1 Mutant HIV-1 RT enzymes containing the single amino acid substitution L1001	B	6.92	pKi	120	nM	Ki	J Med Chem (2001) 44: 305-315 [PMID:11462972]
ChEMBL	Inhibition of HIV1 reverse transcriptase p66/p51 L100I mutant after 30 mins by liquid scintillation counting	B	7.1	pKi	80	nM	Ki	Bioorg Med Chem (2013) 21: 1150-1158 [PMID:23357038]
ChEMBL	Inhibition of DNA-dependent DNA polymerase activity of HIV1 reverse transcriptase p66/p66 homodimer Y181C mutant using activated DNA and [alpha-32P]dATP after 30 mins by liquid scintillation counting	B	7.1	pKi	80	nM	Ki	Bioorg Med Chem (2011) 19: 5794-5802 [PMID:21903401]
ChEMBL	Inhibition of HIV1 reverse transcriptase p66/p51 V106A mutant after 30 mins by liquid scintillation counting	B	7.3	pKi	50	nM	Ki	Bioorg Med Chem (2013) 21: 1150-1158 [PMID:23357038]
ChEMBL	Inhibition of HIV-1 Mutant HIV-1 RT enzymes containing the single amino acid substitution V106A	B	7.4	pKi	40	nM	Ki	J Med Chem (2001) 44: 305-315 [PMID:11462972]
ChEMBL	Inhibition of HIV-1 wild-type RT	B	7.52	pKi	30	nM	Ki	J Med Chem (2001) 44: 305-315 [PMID:11462972]
ChEMBL	Inhibition of wild type HIV1 3B reverse transcriptase	B	7.52	pKi	30	nM	Ki	J Med Chem (2007) 50: 5412-5424 [PMID:17910429]
ChEMBL	Inhibition of RNA dependent DNA polymerase activity of HIV1 recombinant reverse transcriptase p66/p51 expressed in Escherichia coli JM109	B	7.52	pKi	30	nM	Ki	J Med Chem (2009) 52: 1224-1228 [PMID:19170521]
ChEMBL	Inhibition of wild type HIV1 free reverse transcriptase	B	7.52	pKi	30	nM	Ki	J Med Chem (2009) 52: 840-851 [PMID:19140683]
ChEMBL	Inhibition of wild type HIV1 reverse transcriptase-DNA binary complex	B	7.52	pKi	30	nM	Ki	J Med Chem (2009) 52: 840-851 [PMID:19140683]
ChEMBL	Inhibition of HIV1 reverse transcriptase p66/p51 Y181C mutant after 30 mins by liquid scintillation counting	B	7.52	pKi	30	nM	Ki	Bioorg Med Chem (2013) 21: 1150-1158 [PMID:23357038]
ChEMBL	Binding affinity towards L100I mutant HIV-1 reverse transcriptase (as per ref 10 in the article)	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2001) 11: 2799-2802 [PMID:11597403]
ChEMBL	Binding affinity towards L100I mutant HIV-1 reverse transcriptase (as per ref 10 in the article)	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2001) 11: 2799-2802 [PMID:11597403]
ChEMBL	Non-competitive inhibition of wild type HIV1 reverse transcriptase p66/p51 after 30 mins by liquid scintillation counting	B	8	pKi	10	nM	Ki	Bioorg Med Chem (2013) 21: 1150-1158 [PMID:23357038]
ChEMBL	Inhibition of HIV1 reverse transcriptase K103N mutant by SPA assay	B	8.07	pKi	8.5	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4328-4332 [PMID:20609585]
ChEMBL	Inhibition of wild type HIV1 reverse transcriptase-DNA-dNTP ternary complex	B	8.4	pKi	4	nM	Ki	J Med Chem (2009) 52: 840-851 [PMID:19140683]
ChEMBL	Binding affinity towards wild type HIV-1 reverse transcriptase (as per ref 10 in the article)	B	8.52	pKi	3	nM	Ki	Bioorg Med Chem Lett (2001) 11: 2799-2802 [PMID:11597403]
ChEMBL	Binding affinity towards wild type HIV-1 reverse transcriptase (as per ref 10 in the article)	B	8.52	pKi	3	nM	Ki	Bioorg Med Chem Lett (2001) 11: 2799-2802 [PMID:11597403]
ChEMBL	Inhibition of HIV1 reverse transcriptase	B	8.53	pKi	2.93	nM	Ki	J Med Chem (2019) 62: 4851-4883 [PMID:30516990]
ChEMBL	Inhibition of wild type HIV1 reverse transcriptase by SPA assay	B	9.4	pKi	0.4	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4328-4332 [PMID:20609585]
ChEMBL	Inhibition of HIV1 reverse transcriptase Y181C mutant by SPA assay	B	9.52	pKi	0.3	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4328-4332 [PMID:20609585]
ChEMBL	Inhibition of ribonuclease H activity of wild type Human immunodeficiency virus 1 reverse transcriptase	B	4	pIC50	>100000	nM	IC50	Eur J Med Chem (2012) 50: 216-229 [PMID:22361685]
ChEMBL	Inhibition of wild type HIV1 reverse transcriptase K103N mutant assessed as reduction in enzyme activity	B	4.7	pIC50	>20000	nM	IC50	J Med Chem (2014) 57: 9945-9957 [PMID:25418038]
ChEMBL	Inhibition of HIV1 wild-type reverse transcriptase K103N mutant using [3H]dTTP by scintillation counting	B	4.7	pIC50	>20000	nM	IC50	Eur J Med Chem (2014) 80: 101-111 [PMID:24769348]
ChEMBL	Inhibition of HIV1 reverse transcriptase p66 K103N mutant associated RNA dependent DNA polymerase activity expressed in Escherichia coli assessed as reduction in [3H]dTTP incorporation using poly(rA)/oligo(dT) as template/primer by scintillation counting analysis	B	4.7	pIC50	>20000	nM	IC50	J Med Chem (2017) 60: 6528-6547 [PMID:28628334]
ChEMBL	Inhibition of RNA-dependent DNA polymerase activity of recombinant HIV-1 p66/p51 reverse transcriptase K103N mutant assessed as inhibition of [3H]dTTP incorporation using poly(rA)/oligo(dT) as templates incubated for 15 mins by MicroBeta scintillation counting method	B	4.7	pIC50	>20000	nM	IC50	Eur J Med Chem (2020) 208: 112696-112696 [PMID:32883642]
ChEMBL	Inhibitory concentration against HIV-1 mutant reverse transcriptase (K103R)	B	5.68	pIC50	2100	nM	IC50	J Med Chem (2005) 48: 3858-3873 [PMID:15916438]
ChEMBL	Inhibition of wild type HIV1 reverse transcriptase	B	5.82	pIC50	1520	nM	IC50	Bioorg Med Chem (2011) 19: 5924-5934 [PMID:21930388]
ChEMBL	Inhibition of recombinant HIV1 reverse transcriptase K103N/Y181C double mutant using DIG-dUTP/biotin-dUTP/dTTP assessed as suppression of biotin-dUTP incorporation after 1 hr by ELISA	B	5.85	pIC50	1420	nM	IC50	J Med Chem (2016) 59: 7991-8007 [PMID:27541578]
ChEMBL	Inhibition of HIV1 3B reverse transcriptase p66/p51 K103N/Y181C mutant using poly(rA) template and measured after 40 mins by picogreen based spectrofluorometry	B	5.92	pIC50	1200	nM	IC50	Bioorg Med Chem (2016) 24: 2476-2485 [PMID:27112451]
ChEMBL	Inhibition of HIV-1 reverse transcriptase Y188L mutant assessed as reduction in dTTP incorporation using poly(rA)/oligo(dT)16 as template/primer after 40 mins by PicoGreen dye based spectrofluorometric analysis	B	5.92	pIC50	1200	nM	IC50	Bioorg Med Chem (2017) 25: 3861-3870 [PMID:28559060]
ChEMBL	Inhibition of DNA-dependent DNA polymerase activity of HIV1 subtype B reverse transcriptase M230L mutant by gel-based primer extension assay	B	6.04	pIC50	910	nM	IC50	Antimicrob Agents Chemother (2010) 54: 2401-2408 [PMID:20308384]
ChEMBL	Inhibition of HIV1 reverse transcriptase	B	6.1	pIC50	800	nM	IC50	Bioorg Med Chem Lett (2006) 16: 3430-3433 [PMID:16632349]
ChEMBL	Inhibition of HIV-1 BH10 recombinant reverse transcriptase K103N mutant expressed in Escherichia coli assessed as incorporation of [32P]GTP into poly(rA)/oligo(dT) as template primer	B	6.13	pIC50	740	nM	IC50	Bioorg Med Chem (2016) 24: 3006-3022 [PMID:27234889]
ChEMBL	Inhibition of RNA-dependent DNA polymerase activity of HIV1 subtype B reverse transcriptase M230L mutant by filter-based filtration assay	B	6.13	pIC50	740	nM	IC50	Antimicrob Agents Chemother (2010) 54: 2401-2408 [PMID:20308384]
ChEMBL	Inhibition of HIV1 reverse transcriptase p66/p51 K103N mutant using poly(rA) template and measured after 40 mins by picogreen based spectrofluorometry	B	6.14	pIC50	730	nM	IC50	Bioorg Med Chem (2016) 24: 2476-2485 [PMID:27112451]
ChEMBL	Inhibition of RNA-dependent DNA polymerase activity of Human immunodeficiency virus 1 reverse transcriptase Lys103Asn mutant	B	6.17	pIC50	680	nM	IC50	Eur J Med Chem (2012) 50: 216-229 [PMID:22361685]
ChEMBL	Inhibition of HIV1 reverse transcriptase Tyr181Cys mutant-associated RNA-dependent DNA polymerase activity after 30 mins	B	6.17	pIC50	680	nM	IC50	Eur J Med Chem (2015) 93: 452-460 [PMID:25728026]
ChEMBL	Inhibition of HIV-1 reverse transcriptase K103N mutant assessed as reduction in dTTP incorporation using poly(rA)/oligo(dT)16 as template/primer after 40 mins by PicoGreen dye based spectrofluorometric analysis	B	6.2	pIC50	630	nM	IC50	Bioorg Med Chem (2017) 25: 3861-3870 [PMID:28559060]
ChEMBL	Inhibition of HIV1 Reverse transcriptase p51/p66 K103N mutant after 30 mins using alpha-[32P]dATP by liquid scintillation counting	B	6.24	pIC50	580	nM	IC50	Medchemcomm (2013) 4: 1443-1451
ChEMBL	Inhibition of HIV1 reverse transcriptase K103N mutant expressed in Escherichia coli BL21 (DE3) using [alpha-32P]dATP after 30 mins by liquid scintillation counting	B	6.24	pIC50	580	nM	IC50	Medchemcomm (2013) 4: 741-748
ChEMBL	Inhibitory concentration against HIV-1 mutant reverse transcriptase (K103N+Y181C)	B	6.3	pIC50	500	nM	IC50	J Med Chem (2005) 48: 3858-3873 [PMID:15916438]
ChEMBL	Inhibition of HIV1 reverse transcriptase Y181I mutant by RNA-dependent DNA polymerase activity assay	B	6.3	pIC50	500	nM	IC50	Bioorg Med Chem (2010) 18: 1702-1710 [PMID:20097079]
ChEMBL	Inhibition of HIV1 HXB2 reverse transcriptase K103N mutant activity by primer extension assay	B	6.38	pIC50	414	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4451-4463 [PMID:20660667]
ChEMBL	Inhibition of HIV1 reverse transcriptase K103N mutant RNA-dependent DNA polymerase activity using poly(rA)/oligo(dT)10:1 and [3H]-dTTP substrate	B	6.4	pIC50	400	nM	IC50	J Med Chem (2012) 55: 6634-6638 [PMID:22712652]
ChEMBL	Inhibition of wild type HIV1 reverse transcriptase Y181I mutant assessed as reduction in enzyme activity	B	6.4	pIC50	400	nM	IC50	J Med Chem (2014) 57: 9945-9957 [PMID:25418038]
ChEMBL	Inhibition of HIV1 reverse transcriptase p66 Y181I mutant associated RNA dependent DNA polymerase activity expressed in Escherichia coli assessed as reduction in [3H]dTTP incorporation using poly(rA)/oligo(dT) as template/primer by scintillation counting analysis	B	6.4	pIC50	400	nM	IC50	J Med Chem (2017) 60: 6528-6547 [PMID:28628334]
ChEMBL	Inhibition of wild type HIV1 reverse transcriptase Y181I/Y181C mutant assessed as reduction in enzyme activity	B	6.4	pIC50	400	nM	IC50	J Med Chem (2014) 57: 9945-9957 [PMID:25418038]
ChEMBL	Inhibition of HIV1 RT Y188L mutant	B	6.42	pIC50	380	nM	IC50	J Med Chem (2005) 48: 7153-7165 [PMID:16279773]
ChEMBL	Inhibition of RNA-dependent DNA polymerase activity of HIV1 reverse transcriptase K103N mutant	B	6.44	pIC50	364	nM	IC50	J Med Chem (2009) 52: 1219-1223 [PMID:19175319]
ChEMBL	Inhibition of HIV1 reverse transcriptase K103N/Y181C double mutant using poly (A)/oligo (dT)15 as template/primer assessed as decrease in biotin-dUTP incorporation after 1 hr by ELISA	B	6.44	pIC50	360	nM	IC50	Bioorg Med Chem (2018) 26: 2051-2060 [PMID:29559197]
ChEMBL	Inhibition of HIV1 reverse transcriptase Lys103Asn mutant-associated RNA-dependent DNA polymerase activity after 30 mins	B	6.55	pIC50	280	nM	IC50	Eur J Med Chem (2015) 93: 452-460 [PMID:25728026]
ChEMBL	Inhibition of HIV-1 reverse transcriptase L100I mutant assessed as reduction in dTTP incorporation using poly(rA)/oligo(dT)16 as template/primer after 40 mins by PicoGreen dye based spectrofluorometric analysis	B	6.57	pIC50	270	nM	IC50	Bioorg Med Chem (2017) 25: 3861-3870 [PMID:28559060]
ChEMBL	Inhibition of recombinant wild type HIV-1 His-tagged reverse transcriptase p66/p51 expressed in Escherichia coli JM109 using poly(rA)/oligo(dT)16 as template/primer incubated for 40 mins by pico-green based spectrofluorometric analysis	B	6.59	pIC50	260	nM	IC50	Eur J Med Chem (2020) 185: 111874-111874 [PMID:31735575]
ChEMBL	Inhibition of HIV1 reverse transcriptase p66/p51 L100I mutant using poly(rA) template and measured after 40 mins by picogreen based spectrofluorometry	B	6.6	pIC50	250	nM	IC50	Bioorg Med Chem (2016) 24: 2476-2485 [PMID:27112451]
ChEMBL	Inhibition of DNA-dependent DNA polymerase activity of wild-type Human immunodeficiency virus 1 subtype B reverse transcriptase G190A mutant by filter-based filtration assay	B	6.67	pIC50	216	nM	IC50	Antimicrob Agents Chemother (2009) 53: 4667-4672 [PMID:19704127]
ChEMBL	Inhibition of HIV1 reverse transcriptase K103N mutant by RNA-dependent DNA polymerase activity assay	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem (2010) 18: 1702-1710 [PMID:20097079]
ChEMBL	Inhibition of recombinant HIV-1 BH10 reverse transcriptase using D38/[32P]25PGA as template-primer incubated for 5 mins in presence of DTT followed by dTTP addition and measured after 15 to 30 sec by nucleotide incorporation assay	B	6.74	pIC50	180	nM	IC50	Bioorg Med Chem (2021) 30: 115927-115927 [PMID:33352387]
ChEMBL	Inhibition of HIV1 RT K103N mutant	B	6.8	pIC50	160	nM	IC50	J Med Chem (2005) 48: 7153-7165 [PMID:16279773]
ChEMBL	Inhibition of HIV1 RT Y181I mutant	B	6.82	pIC50	150	nM	IC50	J Med Chem (2005) 48: 7153-7165 [PMID:16279773]
ChEMBL	Inhibition of HIV1 reverse transcriptase K103N/Y181C mutant expressed in Escherichia coli BL21 (DE3) using [alpha-32P]dATP after 30 mins by liquid scintillation counting	B	6.85	pIC50	140	nM	IC50	Medchemcomm (2013) 4: 741-748
ChEMBL	Inhibition of HIV1 Reverse transcriptase p51/p66 K103N/Y181C mutant after 30 mins using alpha-[32P]dATP by liquid scintillation counting	B	6.85	pIC50	140	nM	IC50	Medchemcomm (2013) 4: 1443-1451
ChEMBL	Inhibition of Human immunodeficiency virus 1 subtype B reverse transcriptase Y181C mutant by filter-based filtration assay	B	6.9	pIC50	126	nM	IC50	Antimicrob Agents Chemother (2009) 53: 4667-4672 [PMID:19704127]
ChEMBL	Inhibition of wild type HIV1 reverse transcriptase L100I mutant assessed as reduction in enzyme activity	B	6.92	pIC50	120	nM	IC50	J Med Chem (2014) 57: 9945-9957 [PMID:25418038]
ChEMBL	Inhibition of recombinant HIV1 reverse transcriptase using poly rA:dT as template/primer after 1 hr by ELISA	B	6.92	pIC50	120	nM	IC50	Bioorg Med Chem Lett (2013) 23: 6593-6597 [PMID:24239481]
ChEMBL	Inhibition of HIV1 RT L100I mutant	B	6.92	pIC50	120	nM	IC50	J Med Chem (2005) 48: 7153-7165 [PMID:16279773]
ChEMBL	Inhibition of Human immunodeficiency virus 1 subtype B reverse transcriptase G190A mutant by filter-based filtration assay	B	6.95	pIC50	112	nM	IC50	Antimicrob Agents Chemother (2009) 53: 4667-4672 [PMID:19704127]
ChEMBL	Inhibition of HIV-1 reverse transcriptase V106A mutant assessed as reduction in dTTP incorporation using poly(rA)/oligo(dT)16 as template/primer after 40 mins by PicoGreen dye based spectrofluorometric analysis	B	7	pIC50	100	nM	IC50	Bioorg Med Chem (2017) 25: 3861-3870 [PMID:28559060]
ChEMBL	Inhibition of RNA-dependent DNA polymerase activity of wild-type Human immunodeficiency virus 1 subtype B reverse transcriptase by filter-based filtration assay	B	7.03	pIC50	93	nM	IC50	Antimicrob Agents Chemother (2009) 53: 4667-4672 [PMID:19704127]
ChEMBL	Inhibition of HIV1 wild-type reverse transcriptase using [3H]dTTP by scintillation counting	B	7.1	pIC50	80	nM	IC50	Eur J Med Chem (2014) 80: 101-111 [PMID:24769348]
ChEMBL	Inhibition of RNA-dependent DNA polymerase activity of wild type recombinant HIV-1 His-tagged p66/p51 reverse transcriptase assessed as inhibition of [3H]dTTP incorporation using poly(rA)/oligo(dT) as templates incubated for 15 mins by MicroBeta scintillation counting method	B	7.1	pIC50	80	nM	IC50	Eur J Med Chem (2020) 208: 112696-112696 [PMID:32883642]
ChEMBL	Inhibition of HIV1 NL4-3 reverse transcriptase His-tagged p66/p51 associated RNA dependent DNA polymerase activity expressed in Escherichia coli assessed as reduction in [3H]dTTP incorporation using poly(rA)/oligo(dT) as template/primer by scintillation counting analysis	B	7.1	pIC50	80	nM	IC50	J Med Chem (2017) 60: 6528-6547 [PMID:28628334]
ChEMBL	Inhibition of wild type HIV1 reverse transcriptase assessed as reduction in enzyme activity	B	7.1	pIC50	80	nM	IC50	J Med Chem (2014) 57: 9945-9957 [PMID:25418038]
ChEMBL	Inhibition of HIV1 Reverse transcriptase p51/p66 L100I mutant after 30 mins using alpha-[32P]dATP by liquid scintillation counting	B	7.1	pIC50	80	nM	IC50	Medchemcomm (2013) 4: 1443-1451
ChEMBL	Inhibition of wild type HIV1 reverse transcriptase RNA-dependent DNA polymerase activity using poly(rA)/oligo(dT)10:1 and [3H]-dTTP substrate	B	7.1	pIC50	80	nM	IC50	J Med Chem (2012) 55: 6634-6638 [PMID:22712652]
ChEMBL	Inhibition of HIV1 reverse transcriptase L100I mutant expressed in Escherichia coli BL21 (DE3) using [alpha-32P]dATP after 30 mins by liquid scintillation counting	B	7.1	pIC50	80	nM	IC50	Medchemcomm (2013) 4: 741-748
ChEMBL	Inhibition of HIV1 reverse transcriptase p66/p51 Y181C mutant using poly(rA) template and measured after 40 mins by picogreen based spectrofluorometry	B	7.15	pIC50	70	nM	IC50	Bioorg Med Chem (2016) 24: 2476-2485 [PMID:27112451]
ChEMBL	HIV-1 reverse transcriptase inhibitory activity against Asn103 mutant using (poly)rC600*(oligo)dGT as template primer.	B	7.21	pIC50	61	nM	IC50	J Med Chem (1999) 42: 4150-4160 [PMID:10514285]
ChEMBL	Inhibition of reverse transcriptase activity in HIV1 NL4-3 infected MT4 cells after dialysis	B	7.22	pIC50	60	nM	IC50	Antimicrob Agents Chemother (2007) 51: 638-644 [PMID:17116672]
ChEMBL	Inhibition of HIV1 reverse transcriptase G190A mutant expressed in Escherichia coli BL21 (DE3) using [alpha-32P]dATP after 30 mins by liquid scintillation counting	B	7.22	pIC50	60	nM	IC50	Medchemcomm (2013) 4: 741-748
ChEMBL	Inhibition of DNA-dependent DNA polymerase activity of wild type HIV1 subtype B reverse transcriptase by gel-based primer extension assay	B	7.24	pIC50	57	nM	IC50	Antimicrob Agents Chemother (2010) 54: 2401-2408 [PMID:20308384]
ChEMBL	Inhibition of HIV-1 reverse transcriptase G190A mutant assessed as reduction in dTTP incorporation using poly(rA)/oligo(dT)16 as template/primer after 40 mins by PicoGreen dye based spectrofluorometric analysis	B	7.24	pIC50	57	nM	IC50	Bioorg Med Chem (2017) 25: 3861-3870 [PMID:28559060]
ChEMBL	Inhibition of HIV1 reverse transcriptase K103N mutant in 293T cells	B	7.27	pIC50	54	nM	IC50	Bioorg Med Chem Lett (2006) 16: 3034-3038 [PMID:16527484]
ChEMBL	Inhibition of HIV1 reverse transcriptase p66/p51 V106A mutant using poly(rA) template and measured after 40 mins by picogreen based spectrofluorometry	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem (2016) 24: 2476-2485 [PMID:27112451]
ChEMBL	Inhibition of HIV1 reverse transcriptase L100I mutant by RNA-dependent DNA polymerase activity assay	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem (2010) 18: 1702-1710 [PMID:20097079]
ChEMBL	HIV-1 reverse transcriptase inhibitory activity against Ile 100 mutant using (poly)rC600*(oligo)dGT as template primer.	B	7.3	pIC50	50	nM	IC50	J Med Chem (1999) 42: 4150-4160 [PMID:10514285]
ChEMBL	Inhibition of HIV1 reverse transcriptase V106A mutant expressed in Escherichia coli BL21 (DE3) using [alpha-32P]dATP after 30 mins by liquid scintillation counting	B	7.3	pIC50	50	nM	IC50	Medchemcomm (2013) 4: 741-748
ChEMBL	Inhibition of HIV1 Reverse transcriptase p51/p66 V106A mutant after 30 mins using alpha-[32P]dATP by liquid scintillation counting	B	7.3	pIC50	50	nM	IC50	Medchemcomm (2013) 4: 1443-1451
ChEMBL	Inhibitory activity against HIV-1 reverse transcriptase	B	7.32	pIC50	48	nM	IC50	Bioorg Med Chem Lett (1999) 9: 3221-3224 [PMID:10576692]
ChEMBL	Inhibition of recombinant wild type HIV1 RT using poly(rA)/oligo(dT)16 as template after 40 mins by spectrofluorometric analysis	B	7.32	pIC50	48	nM	IC50	Eur J Med Chem (2013) 65: 134-143 [PMID:23707918]
ChEMBL	Inhibitory concentration for 50% inhibition of HIV-1 reverse transcriptase	B	7.32	pIC50	48	nM	IC50	Bioorg Med Chem Lett (2000) 10: 1729-1731 [PMID:10937734]
ChEMBL	Inhibition of HIV-1 reverse transcriptase.	B	7.32	pIC50	48	nM	IC50	Bioorg Med Chem Lett (2001) 11: 1943-1945 [PMID:11459666]
ChEMBL	Inhibitory activity against HIV-1 reverse transcriptase enzyme	B	7.32	pIC50	48	nM	IC50	Bioorg Med Chem Lett (1999) 9: 2805-2810 [PMID:10522695]
ChEMBL	Compound was evaluated for the inhibition of HIV-1 Reverse transcriptase	F	7.33	pIC50	47	nM	IC50	J Med Chem (2000) 43: 2019-2030 [PMID:10821714]
ChEMBL	Inhibition of the NNRTI HIV-1 enzyme by 50% using enzyme assay.	B	7.33	pIC50	47	nM	IC50	Bioorg Med Chem Lett (2001) 11: 309-312 [PMID:11212098]
ChEMBL	Inhibitory activity against HIV-1 reverse transcriptase	B	7.33	pIC50	47	nM	IC50	Bioorg Med Chem Lett (2001) 11: 619-622 [PMID:11266155]
ChEMBL	The compound was evaluated for the inhibition of HIV-1 reverse transcriptase	B	7.33	pIC50	47	nM	IC50	Bioorg Med Chem Lett (2000) 10: 193-195 [PMID:10673109]
ChEMBL	Tested for inhibitory concentration against HIV-1 non-nucleoside reverse transcriptase	B	7.33	pIC50	47	nM	IC50	Bioorg Med Chem Lett (2001) 11: 211-214 [PMID:11206461]
ChEMBL	Inhibition of HIV1 recombinant wild type reverse transcriptase p66/p51 assessed as reduction in biotin-labeled dUTP incorporation into DNA using polyr(A) x oligo(dT)16 template/primer hybrid	B	7.36	pIC50	44	nM	IC50	Eur J Med Chem (2015) 97: 1-9 [PMID:25935383]
ChEMBL	Inhibition of reverse transcriptase activity in HIV1 NL4-3 infected MT4 cells before dialysis	B	7.38	pIC50	42	nM	IC50	Antimicrob Agents Chemother (2007) 51: 638-644 [PMID:17116672]
ChEMBL	Inhibition of recombinant wild type HIV1 reverse transcriptase p66/p51 assessed as reduction in biotin-dUTP incorporation incubated for 40 mins using poly(rA) template and oligo(dT)16 primer by picogreen dye based spectrofluorometry	B	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2017) 140: 383-391 [PMID:28987601]
ChEMBL	Inhibition of HIV1 RT V106A mutant	B	7.4	pIC50	40	nM	IC50	J Med Chem (2005) 48: 7153-7165 [PMID:16279773]
ChEMBL	Inhibition of RNA-dependent DNA polymerase activity of HIV1 reverse transcriptase Y181C mutant	B	7.4	pIC50	40	nM	IC50	J Med Chem (2009) 52: 1219-1223 [PMID:19175319]
ChEMBL	Inhibition of RNA-dependent DNA polymerase activity of Human immunodeficiency virus 1 recombinant reverse transcriptase expressed in Escherichia coli using poly(rA)oligo(dT) template primer after 30 min	B	7.4	pIC50	40	nM	IC50	Med Chem Res (2006) 15: 492-510
ChEMBL	Compound was evaluated for its ability to inhibit HIV-1 Reverse Transcriptase in an in vitro enzyme assay	B	7.42	pIC50	38	nM	IC50	Bioorg Med Chem Lett (2001) 11: 1389-1392 [PMID:11378361]
ChEMBL	Inhibition of HIV1 reverse transcriptase	B	7.42	pIC50	38	nM	IC50	J Med Chem (2019) 62: 4851-4883 [PMID:30516990]
ChEMBL	Inhibition of HIV1 reverse transcriptase	B	7.42	pIC50	38	nM	IC50	Eur J Med Chem (2016) 108: 455-465 [PMID:26708112]
ChEMBL	Inhibition of wild-type HIV1 reverse transcriptase p66/p51 after 40 mins by spectrophotometry	B	7.42	pIC50	38	nM	IC50	Bioorg Med Chem (2014) 22: 2535-2541 [PMID:24680058]
ChEMBL	Inhibition of recombinant wild type HIV1 p66/p51 using poly(rA) template/oligo(dT)16 primer after 40 mins by PicoGreen-based spectrofluorometric method	B	7.42	pIC50	38	nM	IC50	Eur J Med Chem (2016) 121: 352-363 [PMID:27267005]
ChEMBL	Inhibition of HIV-1 wild type recombinant reverse transcriptase p66/p51 assessed as RNA-DNA heteroduplex formation using poly(rA) template/oligo(dT)16 primer incubated prior to enzyme addition by spectrofluorometer analysis	B	7.43	pIC50	37	nM	IC50	Medchemcomm (2014) 5: 468-473
ChEMBL	Inhibition of recombinant wild type HIV-1 reverse transcriptase p66/p51 expressed in Escherichia coli JM109 using poly(rA)/oligo(dT)16 (1:1.2) as template/primer after 40 mins by spectrofluorometric analysis	B	7.43	pIC50	37	nM	IC50	Bioorg Med Chem (2013) 21: 6477-6483 [PMID:24055077]
ChEMBL	Inhibition of DNA-dependent DNA polymerase activity of wild-type Human immunodeficiency virus 1 subtype B reverse transcriptase Y181C mutant by filter-based filtration assay	B	7.44	pIC50	36	nM	IC50	Antimicrob Agents Chemother (2009) 53: 4667-4672 [PMID:19704127]
ChEMBL	Inhibition of HIV1 reverse transcriptase p66/p51 assessed as inhibition of biotin-dUTP incorporation using poly (rA)/oligo(dT)16 as template/primer incubated for 40 mins	B	7.46	pIC50	35	nM	IC50	Eur J Med Chem (2015) 102: 215-222 [PMID:26276435]
ChEMBL	Inhibition of GST-tagged recombinant wild type HIV-1 reverse transcriptase p66/p51 RNA-dependent DNA polymerase activity expressed in Escherichia coli JM109 using dTTP as substrate after 40 mins by spectrofluorometric analysis	B	7.49	pIC50	32	nM	IC50	Bioorg Med Chem (2014) 22: 1459-1467 [PMID:24457088]
ChEMBL	Inhibition of HIV1 reverse transcriptase Y181C mutant expressed in Escherichia coli BL21 (DE3) using [alpha-32P]dATP after 30 mins by liquid scintillation counting	B	7.52	pIC50	30	nM	IC50	Medchemcomm (2013) 4: 741-748
ChEMBL	Inhibition of HIV1 Reverse transcriptase p51/p66 Y181C mutant after 30 mins using alpha-[32P]dATP by liquid scintillation counting	B	7.52	pIC50	30	nM	IC50	Medchemcomm (2013) 4: 1443-1451
ChEMBL	Inhibition of HIV-1 reverse transcriptase E138K mutant assessed as reduction in dTTP incorporation using poly(rA)/oligo(dT)16 as template/primer after 40 mins by PicoGreen dye based spectrofluorometric analysis	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem (2017) 25: 3861-3870 [PMID:28559060]
ChEMBL	Inhibition of HIV-1 reverse transcriptase Y181C mutant assessed as reduction in dTTP incorporation using poly(rA)/oligo(dT)16 as template/primer after 40 mins by PicoGreen dye based spectrofluorometric analysis	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem (2017) 25: 3861-3870 [PMID:28559060]
ChEMBL	Inhibition of RNA-dependent DNA polymerase activity of wild type HIV1 subtype B reverse transcriptase by filter-based filtration assay	B	7.52	pIC50	30	nM	IC50	Antimicrob Agents Chemother (2010) 54: 2401-2408 [PMID:20308384]
ChEMBL	Inhibition of recombinant wild type HIV1 reverse transcriptase assessed as decrease in biotin-dUTP incorporation using DIG-labeled dUTP/biotin-labeled dUTP and dTTP as template and viral nucleotides after 1 hr by ELISA	B	7.52	pIC50	30	nM	IC50	ACS Med Chem Lett (2018) 9: 334-338 [PMID:29670696]
ChEMBL	Inhibition of recombinant wild type HIV1 reverse transcriptase p66/p51 incubated for 40 mins by picogreen dye-based spectrofluorometric analysis	B	7.52	pIC50	30	nM	IC50	J Med Chem (2019) 62: 11430-11436 [PMID:31714780]
ChEMBL	Inhibition of recombinant HIV-1 reverse transcriptase p66/p51 incubated for 40 mins by picogreen dye based spectrofluorometric assay	B	7.52	pIC50	30	nM	IC50	Eur J Med Chem (2019) 182: 111603-111603 [PMID:31421633]
ChEMBL	Inhibition of wild type HIV1 p66/p51 reverse transcriptase by spectrofluorometry	B	7.62	pIC50	24	nM	IC50	Bioorg Med Chem (2015) 23: 624-631 [PMID:25537532]
ChEMBL	Inhibition of HIV1 recombinant wild type reverse transcriptase p66/p51 pre-incubated with compound before enzyme addition using poly(rA) template and measured after 40 mins by picogreen based spectrofluorometry	B	7.66	pIC50	22	nM	IC50	Bioorg Med Chem (2015) 23: 1069-1081 [PMID:25638501]
ChEMBL	Inhibition of wild-type HIV1 Reverse transcriptase p66/p51 assessed as relative fluorescence signal after 40 mins	B	7.66	pIC50	22	nM	IC50	Bioorg Med Chem (2015) 23: 3860-3868 [PMID:25907370]
ChEMBL	Inhibition of HIV1 recombinant wild type reverse transcriptase p66/p51 assessed as reduction in biotin deoxyuridine triphosphate (biotin-dUTP) incorporation using poly(rA)/oligo (dT)16 template and primer by spectrofluorometry	B	7.66	pIC50	22	nM	IC50	Bioorg Med Chem (2015) 23: 4248-4255 [PMID:26162497]
ChEMBL	Inhibition of recombinant HIV1 Reverse transcriptase p66/p51 using poly (rA)-oligo (dT) as template primer after 40 mins by spectrofluorometric analysis	B	7.66	pIC50	22	nM	IC50	Bioorg Med Chem (2015) 23: 6587-6593 [PMID:26385446]
ChEMBL	Inhibition of HIV1 reverse transcriptase assessed as reduction in biotin-dUTP incorporation using poly(rA)-oligo(dT) as template/primer and digoxigenin-/biotin-labeled dUTP nucleotides incubated for 1 hr	B	7.7	pIC50	20	nM	IC50	Eur J Med Chem (2014) 87: 52-62 [PMID:25240095]
ChEMBL	Inhibitory concentration against HIV-1 mutant reverse transcriptase (Y181C)	B	7.7	pIC50	20	nM	IC50	J Med Chem (2005) 48: 3858-3873 [PMID:15916438]
ChEMBL	Inhibition of HIV1 virion-associated reverse transcriptase	B	7.7	pIC50	20	nM	IC50	Bioorg Med Chem (2008) 16: 6353-6363 [PMID:18502646]
ChEMBL	Inhibition of wild type HIV1 reverse transcriptase using poly (A)/oligo (dT)15 as template/primer assessed as decrease in biotin-dUTP incorporation after 1 hr by ELISA	B	7.7	pIC50	20	nM	IC50	Bioorg Med Chem (2018) 26: 2051-2060 [PMID:29559197]
ChEMBL	Inhibition of recombinant wild-type HIV-1 3B reverse transcriptase p66/p51 RNA-dependent DNA polymerase activity expressed in Escherichia coli JM109 assessed as reduction in dTTP incorporation using poly(rA)/oligo(dT)16 as template/primer after 40 mins by PicoGreen dye based spectrofluorometric analysis	B	7.72	pIC50	19	nM	IC50	Bioorg Med Chem (2018) 26: 661-674 [PMID:29291935]
ChEMBL	Inhibition of recombinant wild-type HIV-1 reverse transcriptase p66/p51 RNA-dependent DNA polymerase activity expressed in Escherichia coli JM109 assessed as reduction in dTTP incorporation using poly(rA)/oligo(dT)16 as template/primer after 40 mins by PicoGreen dye based spectrofluorometric analysis	B	7.72	pIC50	19	nM	IC50	Bioorg Med Chem (2017) 25: 3861-3870 [PMID:28559060]
ChEMBL	Inhibition of HIV1 RT polymerase K103N mutant by SPA	B	7.72	pIC50	18.9	nM	IC50	J Med Chem (2008) 51: 6503-6511 [PMID:18826204]
ChEMBL	Inhibition of Human immunodeficiency virus 1 subtype B reverse transcriptase DNA-dependent DNA polymerase activity by gel-based primer extension assay	B	7.74	pIC50	18	nM	IC50	Antimicrob Agents Chemother (2009) 53: 4667-4672 [PMID:19704127]
ChEMBL	Inhibition of HIV1 RT mediated DNA-dependent DNA synthesis initiation using RNA PPT primed substrate by scintillation proximity assay	B	7.77	pIC50	17	nM	IC50	J Biol Chem (2007) 282: 8005-8010 [PMID:17172472]
ChEMBL	Inhibition of HIV1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation into template incubated for 1 hr by ELISA	B	7.85	pIC50	14	nM	IC50	Eur J Med Chem (2019) 182: 111619-111619 [PMID:31434039]
ChEMBL	Inhibition of HIV1 recombinant wild type reverse transcriptase	B	7.85	pIC50	14	nM	IC50	Bioorg Med Chem (2008) 16: 4173-4185 [PMID:18226533]
ChEMBL	Inhibition of RNA-dependent DNA polymerase activity of wild type HIV1 reverse transcriptase	B	7.85	pIC50	14	nM	IC50	J Med Chem (2009) 52: 1219-1223 [PMID:19175319]
ChEMBL	Inhibitory concentration against HIV-1 wild type reverse transcriptase (IIIB)	B	7.85	pIC50	14	nM	IC50	J Med Chem (2005) 48: 3858-3873 [PMID:15916438]
ChEMBL	Inhibition of HIV1 reverse transcriptase-associated RNA-dependent DNA polymerase activity after 30 mins	B	7.92	pIC50	12	nM	IC50	Eur J Med Chem (2015) 93: 452-460 [PMID:25728026]
ChEMBL	Inhibition of HIV1 isolate R8 reverse transcriptase K103N mutant after 90 mins by electrochemiluminescence analysis	B	7.99	pIC50	10.2	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2424-2431 [PMID:19289522]
ChEMBL	Inhibition of recombinant wild type p66/p51 HIV1 reverse transcriptase incubated for 40 mins by picogreen dye-based spectrofluorometric analysis	B	8	pIC50	10	nM	IC50	J Med Chem (2022) 65: 2122-2138 [PMID:35073089]
ChEMBL	Inhibition of reverse transcriptase activity in HIV1 infected HeLa-MAGI cells at 37 deg C after 48 hrs	B	8	pIC50	10	nM	IC50	Antimicrob Agents Chemother (2007) 51: 638-644 [PMID:17116672]
ChEMBL	Inhibition of HIV1 wild type reverse transcriptase expressed in Escherichia coli BL21 (DE3) using [alpha-32P]dATP after 30 mins by liquid scintillation counting	B	8	pIC50	10	nM	IC50	Medchemcomm (2013) 4: 741-748
ChEMBL	Inhibition of wild-type HIV1 Reverse transcriptase p51/p66 after 30 mins using alpha-[32P]dATP by liquid scintillation counting	B	8	pIC50	10	nM	IC50	Medchemcomm (2013) 4: 1443-1451
ChEMBL	Inhibition of HIV1 wild type reverse transcriptase p66/p51 using poly(rA) template and measured after 40 mins by picogreen based spectrofluorometry	B	8	pIC50	10	nM	IC50	Bioorg Med Chem (2016) 24: 2476-2485 [PMID:27112451]
ChEMBL	Inhibition of HIV1 RT using 17-mer DNA/Alexa Fluor 488 5'-end labeled DNA/Alexa Fluor 555-aha-dUTP as primer/template/substrate preincubated for 10 mins followed substarte addition measured after 30 mins by FRET assay	B	8	pIC50	10	nM	IC50	Bioorg Med Chem Lett (2016) 26: 4101-4105 [PMID:27390064]
ChEMBL	Inhibition of recombinant wild type p66/p51 HIV1 reverse transcriptase incubated for 40 mins by picogreen dye-based spectrofluorometric analysis	B	8	pIC50	10	nM	IC50	J Med Chem (2021) 64: 5067-5081 [PMID:33851529]
ChEMBL	Inhibition of recombinant wild-type HIV1 p66/p51 reverse transcriptase assessed as inhibition of [3H]dGTP incorporation using poly (rA) as templates incubated for 40 mins by spectrofluorometer	B	8	pIC50	10	nM	IC50	J Med Chem (2021) 64: 10297-10311 [PMID:34197708]
ChEMBL	Inhibition of wild type HIV1 reverse transcriptase using oligo(dT)16 as primer measured after 40 mins by picogreen-dye based spectrofluorimetric analysis	B	8	pIC50	10	nM	IC50	Eur J Med Chem (2021) 226: 113868-113868 [PMID:34583311]
ChEMBL	Inhibition of HIV1 reverse transcriptase Y188C mutant in 293T cells	B	8.02	pIC50	9.5	nM	IC50	Bioorg Med Chem Lett (2006) 16: 3034-3038 [PMID:16527484]
ChEMBL	Inhibition of HIV1 reverse transcriptase assessed as reduction in biotin-dUTP incorporation into template incubated for 1 hr by ELISA	B	8.09	pIC50	8.13	nM	IC50	Eur J Med Chem (2021) 213: 113051-113051 [PMID:33279288]
ChEMBL	Inhibition of HIV1 reverse transcriptase assessed as reduction in biotin-dUTP incorporation into template incubated for 1 hr by ELISA	B	8.09	pIC50	8.1	nM	IC50	Eur J Med Chem (2021) 213: 113051-113051 [PMID:33279288]
ChEMBL	Inhibition of HIV-1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation into wild type RT measured after 1 hr by ELISA	B	8.1	pIC50	8	nM	IC50	Eur J Med Chem (2021) 214: 113204-113204 [PMID:33567378]
ChEMBL	Inhibition of HIV1 RT polymerase Y181C mutant by SPA	B	8.14	pIC50	7.2	nM	IC50	J Med Chem (2008) 51: 6503-6511 [PMID:18826204]
ChEMBL	Inhibition of HIV1 reverse transcriptase activity by primer extension assay	B	8.14	pIC50	7.2	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4451-4463 [PMID:20660667]
ChEMBL	Inhibition of HIV1 reverse transcriptase p66/p51 using poly(rA)/oligo(dT)16 as template/primer measured after 40 mins by pico-green based spectrofluorometric analysis	B	8.15	pIC50	7.08	nM	IC50	J Med Chem (2019) 62: 2083-2098 [PMID:30721060]
ChEMBL	Inhibition of recombinant wild type HIV1 reverse transcriptase assessed as reduction in biotin-dUTP incorporation using poly(A)/oligo(dT)15 as template/primer after 1 hr by ELISA	B	8.15	pIC50	7	nM	IC50	Bioorg Med Chem (2019) 27: 447-456 [PMID:30606670]
ChEMBL	Inhibition of HIV1 reverse transcriptase p66/p51 using poly(rA)/oligo(dT)16 as template/primer measured after 40 mins by pico-green based spectrofluorometric analysis	B	8.15	pIC50	7	nM	IC50	J Med Chem (2019) 62: 2083-2098 [PMID:30721060]
ChEMBL	Inhibition of HIV1 reverse transcriptase Y181C mutant in 293T cells	B	8.22	pIC50	6	nM	IC50	Bioorg Med Chem Lett (2006) 16: 3034-3038 [PMID:16527484]
ChEMBL	Inhibition of wild-type HIV1 reverse transcriptase infected in human MT4 cells assessed as reduction in biotin-dUTP incorporation	B	8.22	pIC50	6	nM	IC50	ACS Med Chem Lett (2018) 9: 370-375 [PMID:29670703]
ChEMBL	Inhibition of recombinant wild-type HIV1 3B reverse transcriptase assessed as reduction in biotin-dUTP incorporation using poly(rA)/oligo(dT)16 as template primer incubated for 1 hr followed by the addition of (DIG)-dUTP and biotin-labeled dNTPs by ELISA	B	8.22	pIC50	6	nM	IC50	Eur J Med Chem (2019) 176: 11-20 [PMID:31091477]
ChEMBL	HIV-1 reverse transcriptase inhibitory activity against Cys181 mutant using (poly)rC600*(oligo)dGT as template primer.	B	8.22	pIC50	6	nM	IC50	J Med Chem (1999) 42: 4150-4160 [PMID:10514285]
ChEMBL	Inhibition of recombinant wild-type HIV1 GST-fused reverse transcriptase p66/p51 RNA-dependent DNA polymerase activity expressed in Escherichia coli assessed as reduction in biotin-dUTP incorporation using poly(rA)/oligo(dT)16 as template/primer after 40 mins by PicoGreen dye based spectrofluorometric analysis	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2018) 28: 3491-3495 [PMID:30318436]
ChEMBL	Inhibition of HIV1 reverse transcriptase RNA-dependent DNA polymerase activity assessed as incorporation of radioactive dTTP into poly(rA)/oligo(DT)	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem (2008) 16: 7429-7435 [PMID:18585918]
ChEMBL	Concentration required to protect the cell against HIV-1 strain IIIB viral cytopathogenicity by 50% in MT-4 cells	F	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2004) 14: 3173-3176 [PMID:15149669]
ChEMBL	HIV-1 reverse transcriptase inhibitory activity against Wild Type Reverse transcriptase using (poly)rC600*(oligo)dGT as template primer.	B	8.4	pIC50	4	nM	IC50	J Med Chem (1999) 42: 4150-4160 [PMID:10514285]
ChEMBL	Inhibition of HIV1 recombinant RNA-dependent DNA polymerase activity of reverse transcriptase assessed as incorporation of radioactive dTTP into poly(rA)/oligo(dT)	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem (2009) 17: 5962-5967 [PMID:19616956]
ChEMBL	Inhibition of RNA-dependent DNA polymerase activity of HIV1 reverse transcriptase using poly(rA)/pligo(dT) template	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem (2010) 18: 1702-1710 [PMID:20097079]
ChEMBL	Inhibition of RNA dependent DNA polymerase activity of HIV1 recombinant reverse transcriptase	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2007) 17: 1956-1960 [PMID:17276064]
ChEMBL	Inhibition of RNA-dependent DNA polymerase activity of wild type Human immunodeficiency virus 1 reverse transcriptase	B	8.52	pIC50	3	nM	IC50	Eur J Med Chem (2012) 50: 216-229 [PMID:22361685]
ChEMBL	Inhibition of recombinant wild type HIV1 reverse transcriptase p66/p51 using poly (rA)/anoligo (dT)16 as template/primer assessed as inhibition of biotin-dUTP incorporation after 40 mins by Pico-Green staining based fluorescence assay	B	8.7	pIC50	2	nM	IC50	Eur J Med Chem (2018) 145: 726-734 [PMID:29353724]
ChEMBL	Inhibition of wild-type HIV1 reverse transcriptase	B	8.89	pIC50	1.3	nM	IC50	Eur J Med Chem (2009) 44: 2190-2201 [PMID:19058881]
ChEMBL	Inhibition of wild type Human immunodeficiency virus 1 reverse transcriptase after 30 min by fluorescence microplate reader analysis	B	8.89	pIC50	1.3	nM	IC50	Med Chem Res (2010) 19: 311-336
ChEMBL	Inhibition of wild type HIV1 RT polymerase by SPA	B	9	pIC50	1	nM	IC50	J Med Chem (2008) 51: 6503-6511 [PMID:18826204]
ChEMBL	Inhibition of wild type HIV1 reverse transcriptase in 293T cells	B	9.1	pIC50	0.8	nM	IC50	Bioorg Med Chem Lett (2006) 16: 3034-3038 [PMID:16527484]
ChEMBL	Inhibitory concentration against wild-type reverse transcriptase of HIV-1	B	9.12	pIC50	0.75	nM	IC50	J Med Chem (2004) 47: 1175-1182 [PMID:14971897]
ChEMBL	Inhibition of HIV1 isolate R8 reverse transcriptase after 90 mins	B	9.38	pIC50	0.42	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2424-2431 [PMID:19289522]
ChEMBL	Inhibition of HIV1 isolate R8 reverse transcriptase Y181C mutant after 90 mins by electrochemiluminescence analysis	B	9.51	pIC50	0.31	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2424-2431 [PMID:19289522]
ChEMBL	Inhibition of HIV1 recombinant reverse transcriptase assessed as incorporation of [32P]GTP into poly(rC).oligo(dG) template primer	B	9.78	pIC50	0.17	nM	IC50	Medchemcomm (2014) 5: 1685-1692
ChEMBL	Inhibition of wild type HIV-1 NL4-3 reverse transcriptase using random mRNA as template and GADPH as primer measured at 42 degreeC for 5 mins, 95 degreeC for 10sec and 60 degreeC for 60 sec by qRT-PCR analysis	B	10.04	pIC50	0.09	nM	IC50	Eur J Med Chem (2021) 220: 113498-113498 [PMID:33933756]
ChEMBL	Inhibition of HIV-1BH10 reverse transcriptase expressed in Escherichia coli assessed as polymerization by real time FRET assay	B	10.04	pIC50	0.09	nM	IC50	Eur J Med Chem (2020) 186: 111900-111900 [PMID:31771827]
ChEMBL	Inhibition of HIV1 3B reverse transcriptase Y188L mutant infected in human MT4 cells assessed as protection against virus induced cytotoxicity after 5 days by MTT assay	B	6.29	pEC50	514	nM	EC50	J Med Chem (2017) 60: 4424-4443 [PMID:28481112]
ChEMBL	Inhibition of HIV1 3B reverse transcriptase F227L/V106A double mutant infected in human MT4 cells assessed as protection against virus induced cytotoxicity after 5 days by MTT assay	B	6.46	pEC50	348	nM	EC50	J Med Chem (2017) 60: 4424-4443 [PMID:28481112]
ChEMBL	Inhibition of HIV1 RES056 reverse transcriptase K103N/Y181C double mutant infected in human MT4 cells assessed as protection against virus induced cytotoxicity after 5 days by MTT assay	B	6.51	pEC50	308	nM	EC50	J Med Chem (2017) 60: 4424-4443 [PMID:28481112]
ChEMBL	Antiviral activity against HIV1 Y188L mutant in MT4 cells by MTT assay	F	6.52	pEC50	300	nM	EC50	Bioorg Med Chem Lett (2006) 16: 3541-3544 [PMID:16621553]
ChEMBL	Inhibition of HIV1 RES056 reverse transcriptase K103N/Y181C double mutant infected in human MT4 cells assessed as protection against virus-induced cytotoxicity by MTT assay	B	6.65	pEC50	224	nM	EC50	ACS Med Chem Lett (2018) 9: 370-375 [PMID:29670703]
ChEMBL	Antiviral activity against HIV1 IRLL98 in MT4 cells by MTT assay	F	6.7	pEC50	200	nM	EC50	Bioorg Med Chem Lett (2006) 16: 3541-3544 [PMID:16621553]
ChEMBL	Inhibition of HIV1 RES056 reverse transcriptase K103N/Y181C double mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect measured at 5 days post infection by MTT assay	B	6.8	pEC50	160	nM	EC50	Bioorg Med Chem (2017) 25: 2491-2497 [PMID:28314514]
ChEMBL	Inhibition of recombinant HIV-1 reverse transcriptase RNA-dependent DNA polymerase activity using poly(rA)/oligo(dT)16 as template/primer preincubated for 5 to 10 mins followed by template/primer addition and measured after 16 hrs by colorimetric assay	B	6.81	pEC50	156.17	nM	EC50	Eur J Med Chem (2018) 157: 310-319 [PMID:30099253]
ChEMBL	Inhibition of HIV1 3B reverse transcriptase L100I mutant infected in human MT4 cells assessed as protection against virus induced cytotoxicity after 5 days by MTT assay	B	6.94	pEC50	115	nM	EC50	J Med Chem (2017) 60: 4424-4443 [PMID:28481112]
ChEMBL	Inhibition of HIV-1 3B reverse transcriptase K103N mutant infected in human MT4 cells assessed as inhibition of viral replication after 5 days by cell titer glo based luciferase reporter gene assay	B	7	pEC50	101	nM	EC50	Eur J Med Chem (2016) 122: 185-195 [PMID:27371922]
ChEMBL	Inhibition of HIV-1 p66/p51 reverse transcriptase K103N mutant incubated for 40 mins by picogreen dye-based spectrofluorometric analysis	B	7.04	pEC50	91.5	nM	EC50	J Med Chem (2021) 64: 5067-5081 [PMID:33851529]
ChEMBL	Inhibition of HIV1 3B reverse transcriptase K103N mutant infected in human MT4 cells assessed as protection against virus induced cytotoxicity after 5 days by MTT assay	B	7.1	pEC50	80.1	nM	EC50	J Med Chem (2017) 60: 4424-4443 [PMID:28481112]
ChEMBL	Inhibition of reverse transcriptase F227L/V106A double mutant in HIV1 infected in human MT4 cells assessed as protection against virus induced cytotoxicity after 5 days by MTT assay	B	7.24	pEC50	57	nM	EC50	Bioorg Med Chem (2018) 26: 661-674 [PMID:29291935]
ChEMBL	Antiviral activity against HIV1 K103N mutant in MT4 cells by MTT assay	F	7.24	pEC50	57	nM	EC50	Bioorg Med Chem Lett (2006) 16: 3541-3544 [PMID:16621553]
ChEMBL	Inhibition of HIV-1 p66/p51 reverse transcriptase L100I mutant incubated for 40 mins by picogreen dye-based spectrofluorometric analysis	B	7.35	pEC50	44.7	nM	EC50	J Med Chem (2021) 64: 5067-5081 [PMID:33851529]
ChEMBL	Inhibition of reverse transcriptase K103N/Y181C double mutant in HIV1 infected in human MT4 cells assessed as protection against virus induced cytotoxicity after 5 days by MTT assay	B	7.36	pEC50	44	nM	EC50	Bioorg Med Chem (2018) 26: 661-674 [PMID:29291935]
ChEMBL	Inhibition of reverse transcriptase Y188L mutant in HIV1 infected in human MT4 cells assessed as protection against virus induced cytotoxicity after 5 days by MTT assay	B	7.42	pEC50	38	nM	EC50	Bioorg Med Chem (2018) 26: 661-674 [PMID:29291935]
ChEMBL	Inhibition of HIV1 reverse transcriptase K103N mutant by scintillation counting assay	B	7.47	pEC50	34	nM	EC50	Bioorg Med Chem Lett (2008) 18: 4352-4354 [PMID:18632268]
ChEMBL	Inhibition of reverse transcriptase K103N mutant in HIV1 infected in human MT4 cells assessed as protection against virus induced cytotoxicity after 5 days by MTT assay	B	7.54	pEC50	29	nM	EC50	Bioorg Med Chem (2018) 26: 661-674 [PMID:29291935]
ChEMBL	Inhibition of reverse transcriptase L100I mutant in HIV1 infected in human MT4 cells assessed as protection against virus induced cytotoxicity after 5 days by MTT assay	B	7.8	pEC50	16	nM	EC50	Bioorg Med Chem (2018) 26: 661-674 [PMID:29291935]
ChEMBL	Inhibition of HIV1 3B reverse transcriptase Y181C mutant infected in human MT4 cells assessed as protection against virus induced cytotoxicity after 5 days by MTT assay	B	8.09	pEC50	8.2	nM	EC50	J Med Chem (2017) 60: 4424-4443 [PMID:28481112]
ChEMBL	Inhibition of HIV-1 p66/p51 reverse transcriptase Y181C mutant incubated for 40 mins by picogreen dye-based spectrofluorometric analysis	B	8.27	pEC50	5.4	nM	EC50	J Med Chem (2021) 64: 5067-5081 [PMID:33851529]
ChEMBL	Inhibition of HIV-1 reverse transcriptase E138K mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect measured at 5 days post infection by MTT assay	B	8.28	pEC50	5.2	nM	EC50	Bioorg Med Chem (2017) 25: 2491-2497 [PMID:28314514]
ChEMBL	Inhibition of HIV1 3B reverse transcriptase E138K mutant infected in human MT4 cells assessed as protection against virus induced cytotoxicity after 5 days by MTT assay	B	8.28	pEC50	5.19	nM	EC50	J Med Chem (2017) 60: 4424-4443 [PMID:28481112]
ChEMBL	Inhibition of reverse transcriptase Y181C mutant in HIV1 infected in human MT4 cells assessed as protection against virus induced cytotoxicity after 5 days by MTT assay	B	8.3	pEC50	5	nM	EC50	Bioorg Med Chem (2018) 26: 661-674 [PMID:29291935]
ChEMBL	Inhibition of reverse transcriptase Y181C mutant in HIV-1 3B infected in human MT4 cells assessed as inhibition of viral replication after 5 days by cell titer glo based luciferase reporter gene assay	B	8.3	pEC50	5	nM	EC50	Eur J Med Chem (2016) 122: 185-195 [PMID:27371922]
ChEMBL	Inhibition of reverse transcriptase E138K mutant in HIV1 infected in human MT4 cells assessed as protection against virus induced cytotoxicity after 5 days by MTT assay	B	8.4	pEC50	4	nM	EC50	Bioorg Med Chem (2018) 26: 661-674 [PMID:29291935]
ChEMBL	Concentration required to inhibit HIV-1 reverse transcriptase activity (wild-type) by 50%	B	8.4	pEC50	4	nM	EC50	J Med Chem (2005) 48: 4378-4388 [PMID:15974590]
ChEMBL	Inhibition of wild-type HIV1 3B reverse transcriptase infected in human MT4 cells assessed as protection against virus-induced cytopathic effect measured 5 days post infection by MTT assay	B	8.52	pEC50	3	nM	EC50	Eur J Med Chem (2018) 158: 371-392 [PMID:30223123]
ChEMBL	Inhibition of wild-type HIV1 3B reverse transcriptase infected in human MT4 cells assessed as protection against virus-induced cytotoxicity by MTT assay	B	8.55	pEC50	2.85	nM	EC50	ACS Med Chem Lett (2018) 9: 370-375 [PMID:29670703]
ChEMBL	Inhibition of HIV1 reverse transcriptase Y181C mutant by scintillation counting assay	B	8.7	pEC50	2	nM	EC50	Bioorg Med Chem Lett (2008) 18: 4352-4354 [PMID:18632268]
ChEMBL	Inhibition of HIV1 wild-type reverse transcriptase by scintillation counting assay	B	9	pEC50	1	nM	EC50	Bioorg Med Chem Lett (2008) 18: 4352-4354 [PMID:18632268]
ChEMBL	Antiviral activity against wild type HIV1 NL4-3 in MT4 cells by MTT assay	F	9	pEC50	1	nM	EC50	Bioorg Med Chem Lett (2006) 16: 3541-3544 [PMID:16621553]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human O positive erythrocyte assessed as reduction in parasitemia after 72 hrs	F	4.36	pIC50	43820	nM	IC50	Bioorg Med Chem (2014) 22: 5241-5248 [PMID:25199582]
Reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366516] [UniProtKB: Q9WKE8]
ChEMBL	Inhibition of HIV1 reverse transcriptase K103N mutant using oligo(dT)16 as primer measured after 40 mins by picogreen-dye based spectrofluorimetric analysis	B	6.77	pIC50	170	nM	IC50	Eur J Med Chem (2021) 226: 113868-113868 [PMID:34583311]
ChEMBL	Inhibition of HIV1 reverse transcriptase K103N/Y181C double mutant using oligo(dT)16 as primer measured after 40 mins by picogreen-dye based spectrofluorimetric analysis	B	6.92	pIC50	120	nM	IC50	Eur J Med Chem (2021) 226: 113868-113868 [PMID:34583311]
ChEMBL	Inhibition of HIV1 reverse transcriptase Y188L mutant using oligo(dT)16 as primer measured after 40 mins by picogreen-dye based spectrofluorimetric analysis	B	7	pIC50	100	nM	IC50	Eur J Med Chem (2021) 226: 113868-113868 [PMID:34583311]
ChEMBL	Inhibition of HIV1 reverse transcriptase L100I mutant using oligo(dT)16 as primer measured after 40 mins by picogreen-dye based spectrofluorimetric analysis	B	7.7	pIC50	20	nM	IC50	Eur J Med Chem (2021) 226: 113868-113868 [PMID:34583311]
ChEMBL	Inhibition of HIV1 reverse transcriptase F227L/V106A double mutant using oligo(dT)16 as primer measured after 40 mins by picogreen-dye based spectrofluorimetric analysis	B	7.7	pIC50	20	nM	IC50	Eur J Med Chem (2021) 226: 113868-113868 [PMID:34583311]
ChEMBL	Inhibition of HIV1 reverse transcriptase Y181C mutant using oligo(dT)16 as primer measured after 40 mins by picogreen-dye based spectrofluorimetric analysis	B	8	pIC50	10	nM	IC50	Eur J Med Chem (2021) 226: 113868-113868 [PMID:34583311]
ChEMBL	Inhibition of HIV1 reverse transcriptase E138K mutant using oligo(dT)16 as primer measured after 40 mins by picogreen-dye based spectrofluorimetric analysis	B	8	pIC50	10	nM	IC50	Eur J Med Chem (2021) 226: 113868-113868 [PMID:34583311]
ChEMBL	Inhibition of reverse transcriptase F227L/V106A double mutant in HIV-1 infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by MTT assay	B	6.42	pEC50	380	nM	EC50	Eur J Med Chem (2021) 214: 113204-113204 [PMID:33567378]
ChEMBL	Inhibition of reverse transcriptase Y188L mutant in HIV-1 infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by MTT assay	B	6.59	pEC50	260	nM	EC50	Eur J Med Chem (2021) 214: 113204-113204 [PMID:33567378]
ChEMBL	Inhibition of reverse transcriptase Y188L mutant in HIV-1 3B infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by MTT assay	B	6.77	pEC50	171.1	nM	EC50	Eur J Med Chem (2020) 202: 112549-112549 [PMID:32712537]
ChEMBL	Inhibition of reverse transcriptase K103N mutant in HIV-1 3B infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by MTT assay	B	7.12	pEC50	76	nM	EC50	Eur J Med Chem (2020) 202: 112549-112549 [PMID:32712537]
ChEMBL	Inhibition of reverse transcriptase K103N mutant in HIV-1 infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by MTT assay	B	7.15	pEC50	71	nM	EC50	Eur J Med Chem (2021) 214: 113204-113204 [PMID:33567378]
ChEMBL	Inhibition of reverse transcriptase L100I mutant in HIV-1 3B infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by MTT assay	B	7.32	pEC50	47.5	nM	EC50	Eur J Med Chem (2020) 202: 112549-112549 [PMID:32712537]
ChEMBL	Inhibition of reverse transcriptase L100I mutant in HIV-1 infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by MTT assay	B	7.51	pEC50	31	nM	EC50	Eur J Med Chem (2021) 214: 113204-113204 [PMID:33567378]
ChEMBL	Inhibition of reverse transcriptase E138K mutant in HIV-1 3B infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by MTT assay	B	8.15	pEC50	7	nM	EC50	Eur J Med Chem (2020) 202: 112549-112549 [PMID:32712537]
ChEMBL	Inhibition of reverse transcriptase E138K mutant in HIV-1 infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by MTT assay	B	8.3	pEC50	5	nM	EC50	Eur J Med Chem (2021) 214: 113204-113204 [PMID:33567378]
ChEMBL	Inhibition of reverse transcriptase Y181C mutant in HIV-1 3B infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by MTT assay	B	8.32	pEC50	4.8	nM	EC50	Eur J Med Chem (2020) 202: 112549-112549 [PMID:32712537]
CYP3A4 in Human [GtoPdb: 1337] [UniProtKB: P08684]
GtoPdb	Inhibition of CYP3A-mediated conversion of triazolam to 4-OH-triazolam in human liver microsomes.	-	4.76	pIC50	17500	nM	IC50	J Clin Pharmacol (2001) 41: 85-91 [PMID:11225565]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]