ChEMBL ligand: CHEMBL1237 (Lisinopril, MK-521, NSC-751176, NSC-758151, Prinivil, Zestril)
Angiotensin-converting enzyme in Human [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821] Angiotensin-converting enzyme in Rabbit [ChEMBL: CHEMBL4074] [UniProtKB: P12822] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821]
ChEMBL	Inhibition of recombinant ACE N domain	B	6.88	pKi	131.5	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4612-4615 [PMID:16784850]
ChEMBL	Inhibition of somatic ACE N domain	B	6.88	pKi	131.5	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4616-4619 [PMID:16784843]
ChEMBL	Inhibition of testis ACE C domain	B	7.29	pKi	51	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4616-4619 [PMID:16784843]
ChEMBL	Inhibition of recombinant human ACE N-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate addition and measured after 10 mins by fluorescence spectrophotometric analysis	B	8.32	pKi	4.8	nM	Ki	J Med Chem (2022) 65: 3371-3387 [PMID:35113565]
ChEMBL	Inhibition of recombinant human ACE C-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate addition and measured after 10 mins by fluorescence spectrophotometric analysis	B	8.92	pKi	1.2	nM	Ki	J Med Chem (2022) 65: 3371-3387 [PMID:35113565]
GtoPdb	-	-	9.4	pKi	0.36	nM	Ki	Mol Pharmacol (1997) 51: 1070-6 [PMID:9187274]
ChEMBL	Inhibition of ACE (unknown origin) using Hippuryl-L-Histidyl-L-Leucine as substrate after 60 mins by colorimetric method	B	8.1	pIC50	7.92	nM	IC50	Eur J Med Chem (2017) 141: 417-426 [PMID:29032034]
ChEMBL	Inhibitory activity against angiotensin I converting enzyme (ACE)	B	8.33	pIC50	4.7	nM	IC50	J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL	Inhibitory activity against angiotensin converting enzyme (ACE)	F	8.92	pIC50	1.2	nM	IC50	J Med Chem (1993) 36: 2390-2403 [PMID:8360884]
ChEMBL	Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venom	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (2002) 45: 5609-5616 [PMID:12477342]
ChEMBL	Inhibition of Angiotensin I converting enzyme	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (1993) 36: 2051-2058 [PMID:8340909]
ChEMBL	Inhibition of human serum ACE	B	10	pIC50	0.1	nM	IC50	Bioorg Med Chem (2013) 21: 7216-7221 [PMID:24095015]
ChEMBL	Inhibitory activity against Angiotensin I converting enzyme (ACE) from human blood serum	B	10	pIC50	0.1	nM	IC50	J Med Chem (2003) 46: 3326-3332 [PMID:12852763]
Angiotensin-converting enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4074] [UniProtKB: P12822]
ChEMBL	Inhibition of rabbit testis recombinant ACE C domain	B	7.29	pKi	51	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4612-4615 [PMID:16784850]
ChEMBL	Inhibition of rabbit lung ACE assessed as hippuryl-histidyl-leucine hydrolysis after 30 mins by colorimetric method	B	6.5	pIC50	318	nM	IC50	Bioorg Med Chem (2015) 23: 3526-3533 [PMID:25922179]
ChEMBL	Inhibition of rabbit lung ACE using hippuryl-histidyl-leucine as substrate assessed as release of hippuric acid incubated for 10 mins prior to substrate addition measured after 30 mins by spectrophotometry	B	6.55	pIC50	281	nM	IC50	Bioorg Med Chem (2014) 22: 5824-5830 [PMID:25300819]
ChEMBL	Inhibition of rabbit lung ACE assessed as hydrolysis of hippuryl-histidyl-leucine to hippuric acid and histidyl-leucine after 30 mins	B	6.58	pIC50	262	nM	IC50	Bioorg Med Chem (2013) 21: 4485-4493 [PMID:23777825]
ChEMBL	DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG)	B	8.22	pIC50	6.04	nM	IC50	DrugMatrix in vitro pharmacology data

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]