lisinopril [Ligand Id: 6360] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1237 (Lisinopril, Lisinopril hydrate, MK-521, Prinivil, Zestril, Lisinopril dihydrate)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821]
ChEMBL Inhibition of recombinant ACE N domain B 6.88 pKi 131.5 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 4612-4615 [PMID:16784850]
ChEMBL Inhibition of somatic ACE N domain B 6.88 pKi 131.5 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 4616-4619 [PMID:16784843]
ChEMBL Inhibition of testis ACE C domain B 7.29 pKi 51 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 4616-4619 [PMID:16784843]
GtoPdb - - 9.4 pKi 0.36 nM Ki Mol Pharmacol (1997) 51: 1070-6 [PMID:9187274]
ChEMBL Inhibition of ACE (unknown origin) using Hippuryl-L-Histidyl-L-Leucine as substrate after 60 mins by colorimetric method B 8.1 pIC50 7.92 nM IC50 Eur J Med Chem (2017) 141: 417-426 [PMID:29032034]
ChEMBL Inhibitory activity against angiotensin I converting enzyme (ACE) B 8.33 pIC50 4.7 nM IC50 J. Med. Chem. (2000) 43: 305-341 [PMID:10669559]
ChEMBL Inhibitory activity against angiotensin converting enzyme (ACE) F 8.92 pIC50 1.2 nM IC50 J. Med. Chem. (1993) 36: 2390-2403 [PMID:8360884]
ChEMBL Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venom B 8.92 pIC50 1.2 nM IC50 J. Med. Chem. (2002) 45: 5609-5616 [PMID:12477342]
ChEMBL Inhibition of Angiotensin I converting enzyme B 8.92 pIC50 1.2 nM IC50 J. Med. Chem. (1993) 36: 2051-2058 [PMID:8340909]
ChEMBL Inhibition of human serum ACE B 10 pIC50 0.1 nM IC50 Bioorg. Med. Chem. (2013) 21: 7216-7221 [PMID:24095015]
ChEMBL Inhibitory activity against Angiotensin I converting enzyme (ACE) from human blood serum B 10 pIC50 0.1 nM IC50 J. Med. Chem. (2003) 46: 3326-3332 [PMID:12852763]
Angiotensin-converting enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4074] [UniProtKB: P12822]
ChEMBL Inhibition of rabbit testis recombinant ACE C domain B 7.29 pKi 51 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 4612-4615 [PMID:16784850]
ChEMBL Inhibition of rabbit lung ACE assessed as hippuryl-histidyl-leucine hydrolysis after 30 mins by colorimetric method B 6.5 pIC50 318 nM IC50 Bioorg. Med. Chem. (2015) 23: 3526-3533 [PMID:25922179]
ChEMBL Inhibition of rabbit lung ACE using hippuryl-histidyl-leucine as substrate assessed as release of hippuric acid incubated for 10 mins prior to substrate addition measured after 30 mins by spectrophotometry B 6.55 pIC50 281 nM IC50 Bioorg. Med. Chem. (2014) 22: 5824-5830 [PMID:25300819]
ChEMBL Inhibition of rabbit lung ACE assessed as hydrolysis of hippuryl-histidyl-leucine to hippuric acid and histidyl-leucine after 30 mins B 6.58 pIC50 262 nM IC50 Bioorg. Med. Chem. (2013) 21: 4485-4493 [PMID:23777825]
ChEMBL DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) B 8.22 pIC50 6.04 nM IC50 DrugMatrix in vitro pharmacology data

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]