ChEMBL ligand: CHEMBL1237 (Lisinopril anhydrous)
Angiotensin-converting enzyme in Human [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821] Angiotensin-converting enzyme in Rabbit [ChEMBL: CHEMBL4074] [UniProtKB: P12822] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821]
ChEMBL	Inhibition of recombinant ACE N domain	B	6.88	pKi	131.5	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4612-4615 [PMID:16784850]
ChEMBL	Inhibition of somatic ACE N domain	B	6.88	pKi	131.5	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4616-4619 [PMID:16784843]
ChEMBL	Inhibition of testis ACE C domain	B	7.29	pKi	51	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4616-4619 [PMID:16784843]
ChEMBL	Inhibition of recombinant human ACE N-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate addition and measured after 10 mins by fluorescence spectrophotometric analysis	B	8.32	pKi	4.8	nM	Ki	J Med Chem (2022) 65: 3371-3387 [PMID:35113565]
ChEMBL	Inhibition of recombinant human ACE C-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate addition and measured after 10 mins by fluorescence spectrophotometric analysis	B	8.92	pKi	1.2	nM	Ki	J Med Chem (2022) 65: 3371-3387 [PMID:35113565]
GtoPdb	-	-	9.4	pKi	0.36	nM	Ki	Mol Pharmacol (1997) 51: 1070-6 [PMID:9187274]
ChEMBL	Inhibition of ACE (unknown origin) using Hippuryl-L-Histidyl-L-Leucine as substrate after 60 mins by colorimetric method	B	8.1	pIC50	7.92	nM	IC50	Eur J Med Chem (2017) 141: 417-426 [PMID:29032034]
ChEMBL	Inhibitory activity against angiotensin I converting enzyme (ACE)	B	8.33	pIC50	4.7	nM	IC50	J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL	Inhibitory activity against angiotensin converting enzyme (ACE)	F	8.92	pIC50	1.2	nM	IC50	J Med Chem (1993) 36: 2390-2403 [PMID:8360884]
ChEMBL	Inhibition of Angiotensin I converting enzyme	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (1993) 36: 2051-2058 [PMID:8340909]
ChEMBL	Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venom	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (2002) 45: 5609-5616 [PMID:12477342]
ChEMBL	Inhibition of angiotensin-converting enzyme (unknown origin)	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (2016) 59: 10865-10890 [PMID:27690430]
ChEMBL	Inhibitory activity against Angiotensin I converting enzyme (ACE) from human blood serum	B	10	pIC50	0.1	nM	IC50	J Med Chem (2003) 46: 3326-3332 [PMID:12852763]
ChEMBL	Inhibition of angiotensin converting enzyme (unknown origin)	B	10	pIC50	0.1	nM	IC50	Eur J Med Chem (2021) 226: 113877-113877 [PMID:34624823]
ChEMBL	Inhibition of human serum ACE	B	10	pIC50	0.1	nM	IC50	Bioorg Med Chem (2013) 21: 7216-7221 [PMID:24095015]
Angiotensin-converting enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4074] [UniProtKB: P12822]
ChEMBL	Inhibition of rabbit testis recombinant ACE C domain	B	7.29	pKi	51	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4612-4615 [PMID:16784850]
ChEMBL	Inhibition of rabbit lung ACE assessed as hippuryl-histidyl-leucine hydrolysis after 30 mins by colorimetric method	B	6.5	pIC50	318	nM	IC50	Bioorg Med Chem (2015) 23: 3526-3533 [PMID:25922179]
ChEMBL	Inhibition of rabbit lung ACE using hippuryl-histidyl-leucine as substrate assessed as release of hippuric acid incubated for 10 mins prior to substrate addition measured after 30 mins by spectrophotometry	B	6.55	pIC50	281	nM	IC50	Bioorg Med Chem (2014) 22: 5824-5830 [PMID:25300819]
ChEMBL	Inhibition of rabbit lung ACE assessed as hydrolysis of hippuryl-histidyl-leucine to hippuric acid and histidyl-leucine after 30 mins	B	6.58	pIC50	262	nM	IC50	Bioorg Med Chem (2013) 21: 4485-4493 [PMID:23777825]
ChEMBL	DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG)	B	8.22	pIC50	6.04	nM	IC50	DrugMatrix in vitro pharmacology data

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]