enarodustat   Click here for help

GtoPdb Ligand ID: 11828

Synonyms: compound 14 [PMID: 29259755] | Enaroy® | JTZ-951 | JTZ951
Approved drug
enarodustat is an approved drug
Compound class: Synthetic organic
Comment: Enarodustat (JTZ-951) is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) enzyme activity [3]. Inhibition of prolyl hydroxylation of HIF transcription factors is used as an alternative to erythropoiesis-stimulating agents (epoetin, darbepoetin) for the treatment of anaemia resulting from chronic kidnery disease [1,4].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 116.56
Molecular weight 340.12
XLogP 2.55
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES OC(=O)CNC(=O)c1c(=O)cc(n2c1nc[nH]2)CCc1ccccc1
Isomeric SMILES c1ccc(cc1)CCc1cc(=O)c(c2n1[nH]cn2)C(=O)NCC(=O)O
InChI InChI=1S/C17H16N4O4/c22-13-8-12(7-6-11-4-2-1-3-5-11)21-16(19-10-20-21)15(13)17(25)18-9-14(23)24/h1-5,8,10H,6-7,9H2,(H,18,25)(H,19,20)(H,23,24)
InChI Key FJYRBJKWDXVHHO-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes
International Nonproprietary Names Click here for help
INN number INN
10572 enarodustat
Synonyms Click here for help
compound 14 [PMID: 29259755] | Enaroy® | JTZ-951 | JTZ951
Database Links Click here for help
CAS Registry No. 1262132-81-9 (source: WHO INN record)
ChEMBL Ligand CHEMBL4297619
DrugBank Ligand DB14985
GtoPdb PubChem SID 461663384
PubChem CID 50899324
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UniChem Compound Search for chemical match using the InChIKey FJYRBJKWDXVHHO-UHFFFAOYSA-N
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