P6949 [Ligand Id: 8877] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2057662 (3-(3-Stibonophenyl)Propanoic Acid)
  • Dual specificity phosphatase Cdc25A in Human [ChEMBL: CHEMBL3775] [UniProtKB: P30304]
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  • Dual specificity phosphatase Cdc25B in Human [ChEMBL: CHEMBL4804] [UniProtKB: P30305]
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  • Dual specificity phosphatase Cdc25C in Human [ChEMBL: CHEMBL2378] [UniProtKB: P30307]
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  • Dual specificity protein phosphatase 3 in Human [ChEMBL: CHEMBL2635] [UniProtKB: P51452]
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  • phosphatase and tensin homolog/Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN in Human [ChEMBL: CHEMBL2052032] [GtoPdb: 2497] [UniProtKB: P60484]
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  • protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
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  • Protein-tyrosine phosphatase mitochondrial 1 in Human [ChEMBL: CHEMBL2052033] [UniProtKB: Q8WUK0]
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  • RTP Type B/Receptor-type tyrosine-protein phosphatase beta in Human [ChEMBL: CHEMBL2706] [GtoPdb: 1851] [UniProtKB: P23467]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Dual specificity phosphatase Cdc25A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3775] [UniProtKB: P30304]
ChEMBL Inhibition of N-terminal His-tagged Cdc25a catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate by secondary plot analysis B 5.77 pKi 1700 nM Ki Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189]
ChEMBL Inhibition of N-terminal His-tagged Cdc25a catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry B 5.5 pIC50 3150 nM IC50 Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189]
Dual specificity phosphatase Cdc25B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4804] [UniProtKB: P30305]
ChEMBL Inhibition of N-terminal His-tagged Cdc25b catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate by secondary plot analysis B 5.33 pKi 4700 nM Ki Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189]
ChEMBL Inhibition of N-terminal His-tagged Cdc25b catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry B 5.25 pIC50 5670 nM IC50 Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189]
Dual specificity phosphatase Cdc25C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2378] [UniProtKB: P30307]
ChEMBL Inhibition of N-terminal His-tagged Cdc25c catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry B 4 pIC50 >100000 nM IC50 Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189]
Dual specificity protein phosphatase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2635] [UniProtKB: P51452]
ChEMBL Inhibition of human recombinant His-tagged VHR using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry B 4 pIC50 >100000 nM IC50 Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189]
Dual specificity protein phosphatase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250381] [UniProtKB: Q16828]
ChEMBL Inhibition of MKP3 using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry B 4 pIC50 >100000 nM IC50 Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189]
phosphatase and tensin homolog/Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2052032] [GtoPdb: 2497] [UniProtKB: P60484]
GtoPdb - - 5.05 pIC50 8870 nM IC50 Bioorg Med Chem (2012) 20: 4371-6 [PMID:22705189]
ChEMBL Inhibition of human PTEN using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry B 5.05 pIC50 8870 nM IC50 Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189]
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
ChEMBL Inhibition of PTP1B using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry B 4 pIC50 >100000 nM IC50 Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189]
Protein-tyrosine phosphatase mitochondrial 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2052033] [UniProtKB: Q8WUK0]
ChEMBL Inhibition of PTPMT1 using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry B 4.87 pIC50 13440 nM IC50 Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189]
RTP Type B/Receptor-type tyrosine-protein phosphatase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2706] [GtoPdb: 1851] [UniProtKB: P23467]
ChEMBL Inhibition of PTP-beta receptor using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry B 5.79 pIC50 1620 nM IC50 Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189]
ChEMBL Inhibition of PTP-beta receptor using para-nitrophenol as substrate by colorimetric analysis B 7 pIC50 100 nM IC50 Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]