P6949 [Ligand Id: 8877] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2057662 (3-(3-Stibonophenyl)Propanoic Acid)
  • Dual specificity phosphatase Cdc25A in Human [ChEMBL: CHEMBL3775] [UniProtKB: P30304]
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  • Dual specificity phosphatase Cdc25B in Human [ChEMBL: CHEMBL4804] [UniProtKB: P30305]
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  • Dual specificity phosphatase Cdc25C in Human [ChEMBL: CHEMBL2378] [UniProtKB: P30307]
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  • Dual specificity protein phosphatase 3 in Human [ChEMBL: CHEMBL2635] [UniProtKB: P51452]
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  • phosphatase and tensin homolog/Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN in Human [ChEMBL: CHEMBL2052032] [GtoPdb: 2497] [UniProtKB: P60484]
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  • protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
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  • Protein-tyrosine phosphatase mitochondrial 1 in Human [ChEMBL: CHEMBL2052033] [UniProtKB: Q8WUK0]
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  • RTP Type B/Receptor-type tyrosine-protein phosphatase beta in Human [ChEMBL: CHEMBL2706] [GtoPdb: 1851] [UniProtKB: P23467]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Dual specificity phosphatase Cdc25A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3775] [UniProtKB: P30304]
ChEMBL Inhibition of N-terminal His-tagged Cdc25a catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate by secondary plot analysis B 5.77 pKi 1700 nM Ki Bioorg. Med. Chem. (2012) 20: 4371-4376 [PMID:22705189]
ChEMBL Inhibition of N-terminal His-tagged Cdc25a catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry B 5.5 pIC50 3150 nM IC50 Bioorg. Med. Chem. (2012) 20: 4371-4376 [PMID:22705189]
Dual specificity phosphatase Cdc25B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4804] [UniProtKB: P30305]
ChEMBL Inhibition of N-terminal His-tagged Cdc25b catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate by secondary plot analysis B 5.33 pKi 4700 nM Ki Bioorg. Med. Chem. (2012) 20: 4371-4376 [PMID:22705189]
ChEMBL Inhibition of N-terminal His-tagged Cdc25b catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry B 5.25 pIC50 5670 nM IC50 Bioorg. Med. Chem. (2012) 20: 4371-4376 [PMID:22705189]
Dual specificity phosphatase Cdc25C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2378] [UniProtKB: P30307]
ChEMBL Inhibition of N-terminal His-tagged Cdc25c catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry B 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. (2012) 20: 4371-4376 [PMID:22705189]
Dual specificity protein phosphatase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2635] [UniProtKB: P51452]
ChEMBL Inhibition of human recombinant His-tagged VHR using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry B 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. (2012) 20: 4371-4376 [PMID:22705189]
Dual specificity protein phosphatase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250381] [UniProtKB: Q16828]
ChEMBL Inhibition of MKP3 using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry B 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. (2012) 20: 4371-4376 [PMID:22705189]
phosphatase and tensin homolog/Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2052032] [GtoPdb: 2497] [UniProtKB: P60484]
GtoPdb - - 5.05 pIC50 8870 nM IC50 Bioorg Med Chem (2012) 20: 4371-6 [PMID:22705189]
ChEMBL Inhibition of human PTEN using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry B 5.05 pIC50 8870 nM IC50 Bioorg. Med. Chem. (2012) 20: 4371-4376 [PMID:22705189]
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
ChEMBL Inhibition of PTP1B using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry B 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. (2012) 20: 4371-4376 [PMID:22705189]
Protein-tyrosine phosphatase mitochondrial 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2052033] [UniProtKB: Q8WUK0]
ChEMBL Inhibition of PTPMT1 using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry B 4.87 pIC50 13440 nM IC50 Bioorg. Med. Chem. (2012) 20: 4371-4376 [PMID:22705189]
RTP Type B/Receptor-type tyrosine-protein phosphatase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2706] [GtoPdb: 1851] [UniProtKB: P23467]
ChEMBL Inhibition of PTP-beta receptor using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry B 5.79 pIC50 1620 nM IC50 Bioorg. Med. Chem. (2012) 20: 4371-4376 [PMID:22705189]
ChEMBL Inhibition of PTP-beta receptor using para-nitrophenol as substrate by colorimetric analysis B 7 pIC50 100 nM IC50 Bioorg. Med. Chem. (2012) 20: 4371-4376 [PMID:22705189]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]