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RTP Type B

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Target not currently curated in GtoImmuPdb

Target id: 1851

Nomenclature: RTP Type B

Family: Receptor tyrosine phosphatase (RTP) family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 1997 12q15 PTPRB protein tyrosine phosphatase receptor type B
Mouse 1 1998 10 D2 Ptprb protein tyrosine phosphatase receptor type B
Rat - - Ptprb protein tyrosine phosphatase, receptor type, B
Previous and Unofficial Names Click here for help
vascular endothelial protein tyrosine phosphatase | VEPTP | protein tyrosine phosphatase, receptor type, B | protein tyrosine phosphatase | protein tyrosine phosphatase, receptor type B
Database Links Click here for help
Alphafold P23467 (Hs), B2RU80 (Mm)
CATH/Gene3D 2.60.40.10, 3.90.190.10
ChEMBL Target CHEMBL2706 (Hs)
Ensembl Gene ENSG00000127329 (Hs), ENSMUSG00000020154 (Mm), ENSRNOG00000055293 (Rn)
Entrez Gene 5787 (Hs), 19263 (Mm), 314843 (Rn)
Human Protein Atlas ENSG00000127329 (Hs)
KEGG Gene hsa:5787 (Hs), mmu:19263 (Mm), rno:314843 (Rn)
OMIM 176882 (Hs)
Pharos P23467 (Hs)
UniProtKB P23467 (Hs), B2RU80 (Mm)
Wikipedia PTPRB (Hs)

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 13e [PMID: 16759857] Small molecule or natural product Hs Inhibition 7.2 pIC50 1
⤷ pIC50 7.2 (IC50 7x10-8 M) [1]
razuprotafib Small molecule or natural product Hs Inhibition 6.2 pIC50 4
⤷ pIC50 6.2 (IC50 7x10-7 M) [4]
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Cellular signalling
General Comments
RTP Type B (HPTPβ) is mainly expressed in endothelial cells and negatively regulates Tie2 (TEK) activity (by de-phosphorylation) [2]. Since Tie2 is a receptor tyrosine kinase for the angiopoietin growth factors [3], RTP Type B may also be important in vascular biology [5].

References

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1. Amarasinghe KK, Evdokimov AG, Evidokimov AG, Xu K, Clark CM, Maier MB, Srivastava A, Colson AO, Gerwe GS, Stake GE et al.. (2006) Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta. Bioorg Med Chem Lett, 16 (16): 4252-6. [PMID:16759857]

2. Fachinger G, Deutsch U, Risau W. (1999) Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2. Oncogene, 18 (43): 5948-53. [PMID:10557082]

3. Gale NW, Yancopoulos GD. (1999) Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes Dev, 13 (9): 1055-66. [PMID:10323857]

4. Peters K, Shalwitz R. (2019) Compositions and methods for treating ocular diseases. Patent number: US10220048. Assignee: Aerpio Therapeutics. Priority date: 15/03/2013. Publication date: 05/03/2019.

5. Wright MB, Seifert RA, Bowen-Pope DF. (2000) Protein-tyrosine phosphatases in the vessel wall: differential expression after acute arterial injury. Arterioscler Thromb Vasc Biol, 20 (5): 1189-98. [PMID:10807732]

How to cite this page

Receptor tyrosine phosphatase (RTP) family: RTP Type B. Last modified on 17/11/2020. Accessed on 18/03/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1851.