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RTP Type B

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Target not currently curated in GtoImmuPdb

Target id: 1851

Nomenclature: RTP Type B

Family: Receptor tyrosine phosphatase (RTP) family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 1997 12q15 PTPRB protein tyrosine phosphatase receptor type B
Mouse 1 1998 10 D2 Ptprb protein tyrosine phosphatase receptor type B
Rat - - Ptprb protein tyrosine phosphatase, receptor type, B
Previous and Unofficial Names Click here for help
vascular endothelial protein tyrosine phosphatase | VEPTP | protein tyrosine phosphatase, receptor type, B | protein tyrosine phosphatase | protein tyrosine phosphatase, receptor type B
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 13e [PMID: 16759857] Small molecule or natural product Hs Inhibition 7.2 pIC50 1
pIC50 7.2 (IC50 7x10-8 M) [1]
razuprotafib Small molecule or natural product Hs Inhibition 6.2 pIC50 4
pIC50 6.2 (IC50 7x10-7 M) [4]
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Cellular signalling
General Comments
RTP Type B (HPTPβ) is mainly expressed in endothelial cells and negatively regulates Tie2 (TEK) activity (by de-phosphorylation) [2]. Since Tie2 is a receptor tyrosine kinase for the angiopoietin growth factors [3], RTP Type B may also be important in vascular biology [5].


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1. Amarasinghe KK, Evdokimov AG, Evidokimov AG, Xu K, Clark CM, Maier MB, Srivastava A, Colson AO, Gerwe GS, Stake GE et al.. (2006) Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta. Bioorg Med Chem Lett, 16 (16): 4252-6. [PMID:16759857]

2. Fachinger G, Deutsch U, Risau W. (1999) Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2. Oncogene, 18 (43): 5948-53. [PMID:10557082]

3. Gale NW, Yancopoulos GD. (1999) Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes Dev, 13 (9): 1055-66. [PMID:10323857]

4. Peters K, Shalwitz R. (2019) Compositions and methods for treating ocular diseases. Patent number: US10220048. Assignee: Aerpio Therapeutics. Priority date: 15/03/2013. Publication date: 05/03/2019.

5. Wright MB, Seifert RA, Bowen-Pope DF. (2000) Protein-tyrosine phosphatases in the vessel wall: differential expression after acute arterial injury. Arterioscler Thromb Vasc Biol, 20 (5): 1189-98. [PMID:10807732]

How to cite this page

Receptor tyrosine phosphatase (RTP) family: RTP Type B. Last modified on 17/11/2020. Accessed on 24/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,