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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 1997 | 12q15 | PTPRB | protein tyrosine phosphatase receptor type B | |
Mouse | 1 | 1998 | 10 D2 | Ptprb | protein tyrosine phosphatase receptor type B | |
Rat | - | - | Ptprb | protein tyrosine phosphatase, receptor type, B |
Database Links ![]() |
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Alphafold | P23467 (Hs), B2RU80 (Mm) |
CATH/Gene3D | 2.60.40.10, 3.90.190.10 |
ChEMBL Target | CHEMBL2706 (Hs) |
Ensembl Gene | ENSG00000127329 (Hs), ENSMUSG00000020154 (Mm), ENSRNOG00000055293 (Rn) |
Entrez Gene | 5787 (Hs), 19263 (Mm), 314843 (Rn) |
Human Protein Atlas | ENSG00000127329 (Hs) |
KEGG Gene | hsa:5787 (Hs), mmu:19263 (Mm), rno:314843 (Rn) |
OMIM | 176882 (Hs) |
Pharos | P23467 (Hs) |
UniProtKB | P23467 (Hs), B2RU80 (Mm) |
Wikipedia | PTPRB (Hs) |
Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | ||
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General Comments |
RTP Type B (HPTPβ) is mainly expressed in endothelial cells and negatively regulates Tie2 (TEK) activity (by de-phosphorylation) [2]. Since Tie2 is a receptor tyrosine kinase for the angiopoietin growth factors [3], RTP Type B may also be important in vascular biology [5]. |
1. Amarasinghe KK, Evdokimov AG, Evidokimov AG, Xu K, Clark CM, Maier MB, Srivastava A, Colson AO, Gerwe GS, Stake GE et al.. (2006) Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta. Bioorg Med Chem Lett, 16 (16): 4252-6. [PMID:16759857]
2. Fachinger G, Deutsch U, Risau W. (1999) Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2. Oncogene, 18 (43): 5948-53. [PMID:10557082]
3. Gale NW, Yancopoulos GD. (1999) Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes Dev, 13 (9): 1055-66. [PMID:10323857]
4. Peters K, Shalwitz R. (2019) Compositions and methods for treating ocular diseases. Patent number: US10220048. Assignee: Aerpio Therapeutics. Priority date: 15/03/2013. Publication date: 05/03/2019.
5. Wright MB, Seifert RA, Bowen-Pope DF. (2000) Protein-tyrosine phosphatases in the vessel wall: differential expression after acute arterial injury. Arterioscler Thromb Vasc Biol, 20 (5): 1189-98. [PMID:10807732]
Receptor tyrosine phosphatase (RTP) family: RTP Type B. Last modified on 17/11/2020. Accessed on 18/03/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1851.