AC-7954 [Ligand Id: 2151] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL192359 (AC-7954) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| UT receptor/Urotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3764] [GtoPdb: 365] [UniProtKB: Q9UKP6] | ||||||||
| GtoPdb | - | - | 6.6 | pKi | - | - | - |
J Med Chem (2002) 45: 4950-3 [PMID:12408704]; Bioorg Med Chem (2005) 13: 3057-68 [PMID:15781415] |
| ChEMBL | Activity against human urotensin-2 receptor expressed in NIH3T3 cells | B | 5.95 | pEC50 | 1122.02 | nM | EC50 | J Med Chem (2006) 49: 2232-2240 [PMID:16570919] |
| ChEMBL | Agonist activity against human urotensin 2 receptor expressed in human NIH373 cells assessed as beta-galactosidase activity after 5 days by R-SAT assay | F | 5.95 | pEC50 | >=1122.02 | nM | EC50 | Bioorg Med Chem (2009) 17: 4657-4665 [PMID:19481466] |
| ChEMBL | Agonist activity against human urotensin 2 receptor expressed in human NIH373 cells assessed as beta-galactosidase activity after 5 days by R-SAT assay | F | 5.95 | pEC50 | 1122.02 | nM | EC50 | Bioorg Med Chem (2010) 18: 4844-4854 [PMID:20570157] |
| ChEMBL | Agonist activity for human Urotensin 2 receptor | F | 6.52 | pEC50 | 300 | nM | EC50 | J Med Chem (2005) 48: 2480-2492 [PMID:15801838] |
| ChEMBL | Agonist activity at human urotensin 2 expressed in CHO cells by FLIPR | F | 6.6 | pEC50 | 250 | nM | EC50 | J Med Chem (2010) 53: 2695-2708 [PMID:20043680] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
