PD-140548 [Ligand Id: 904] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL356898 (PD-140548)
  • CCK1 receptor/Cholecystokinin A receptor in Rat [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551]
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  • CCK2 receptor/Cholecystokinin B receptor in Mouse [ChEMBL: CHEMBL2854] [GtoPdb: 77] [UniProtKB: P56481]
  • CCK2 receptor in Rat [GtoPdb: 77] [UniProtKB: P30553]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551]
ChEMBL In vitro inhibition of [125I]- Bolton Hunter CCK-8 to Cholecystokinin type A receptor in the rat pancreas. B 7.59 pIC50 25.5 nM IC50 Bioorg Med Chem Lett (1993) 3: 2805-2810
ChEMBL Inhibition of [3H]propionyl-CCK-8 binding to rat pancreas cholecystokinin-A (CCK-A) receptor B 8.55 pIC50 2.8 nM IC50 Bioorg Med Chem Lett (1999) 9: 43-48 [PMID:9990454]
ChEMBL Inhibition of [125I]CCK-8 binding to Cholecystokinin type A receptor of rat pancreas B 8.55 pIC50 2.8 nM IC50 Bioorg Med Chem Lett (1993) 3: 881-884
GtoPdb - - 8.6 pIC50 2.5 nM IC50 Eur J Pharmacol (1995) 286: 185-91 [PMID:8605955]
CCK2 receptor/Cholecystokinin B receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2854] [GtoPdb: 77] [UniProtKB: P56481]
ChEMBL Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse B 6.61 pKi 245.47 nM Ki J Med Chem (1992) 35: 1572-1577 [PMID:1578483]
ChEMBL Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor B 6.59 pIC50 259 nM IC50 Bioorg Med Chem Lett (1999) 9: 43-48 [PMID:9990454]
ChEMBL Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex. B 6.59 pIC50 259 nM IC50 Bioorg Med Chem Lett (1993) 3: 881-884
ChEMBL In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex. B 9.82 pIC50 0.15 nM IC50 Bioorg Med Chem Lett (1993) 3: 2805-2810
CCK2 receptor in Rat [GtoPdb: 77] [UniProtKB: P30553]
GtoPdb - - 6.6 pIC50 - - - J Med Chem (1993) 36: 552-565 [PMID:7684452]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]