PD-140548 [Ligand Id: 904] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL356898 (PD-140548) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551] | ||||||||
| ChEMBL | In vitro inhibition of [125I]- Bolton Hunter CCK-8 to Cholecystokinin type A receptor in the rat pancreas. | B | 7.59 | pIC50 | 25.5 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 2805-2810 |
| ChEMBL | Inhibition of [3H]propionyl-CCK-8 binding to rat pancreas cholecystokinin-A (CCK-A) receptor | B | 8.55 | pIC50 | 2.8 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 43-48 [PMID:9990454] |
| ChEMBL | Inhibition of [125I]CCK-8 binding to Cholecystokinin type A receptor of rat pancreas | B | 8.55 | pIC50 | 2.8 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 881-884 |
| GtoPdb | - | - | 8.6 | pIC50 | 2.5 | nM | IC50 | Eur J Pharmacol (1995) 286: 185-91 [PMID:8605955] |
| CCK2 receptor/Cholecystokinin B receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2854] [GtoPdb: 77] [UniProtKB: P56481] | ||||||||
| ChEMBL | Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse | B | 6.61 | pKi | 245.47 | nM | Ki | J Med Chem (1992) 35: 1572-1577 [PMID:1578483] |
| ChEMBL | Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor | B | 6.59 | pIC50 | 259 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 43-48 [PMID:9990454] |
| ChEMBL | Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex. | B | 6.59 | pIC50 | 259 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 881-884 |
| ChEMBL | In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex. | B | 9.82 | pIC50 | 0.15 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 2805-2810 |
| CCK2 receptor in Rat [GtoPdb: 77] [UniProtKB: P30553] | ||||||||
| GtoPdb | - | - | 6.6 | pIC50 | - | - | - | J Med Chem (1993) 36: 552-565 [PMID:7684452] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
