nabilone [Ligand Id: 9071] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2218896 (CPD-109514, CPD 109514, Nabilone, Cesamet)
  • CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
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  • CB2 receptor/Cannabinoid CB2 receptor in Human [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
GtoPdb - - 8.4 pKi 3.98 nM Ki Eur J Med Chem (2011) 46: 5086-98 [PMID:21885167]
ChEMBL Displacement of [3H]-CP55940 from human CB1 receptor expressed in CHO cells by liquid scintillation counting B 8.4 pKi 3.98 nM Ki Eur. J. Med. Chem. (2011) 46: 5086-5098 [PMID:21885167]
ChEMBL Agonist activity at human CB1 receptor expressed in CHO cells assessed as stimulation of [3H]-arachidonic acid release F 8.4 pEC50 3.98 nM EC50 Eur. J. Med. Chem. (2011) 46: 5086-5098 [PMID:21885167]
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
ChEMBL Displacement of [3H]-CP55940 from human CB2 receptor expressed in CHO cells by liquid scintillation counting B 8.2 pKi 6.31 nM Ki Eur. J. Med. Chem. (2011) 46: 5086-5098 [PMID:21885167]
GtoPdb - - 8.2 pKi 6.31 nM Ki Eur J Med Chem (2011) 46: 5086-98 [PMID:21885167]
ChEMBL Agonist activity at human CB2 receptor expressed in CHO cells assessed as increase of forskolin-stimulated cAMP accumulation after 20 mins F 7.8 pEC50 15.85 nM EC50 Eur. J. Med. Chem. (2011) 46: 5086-5098 [PMID:21885167]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]