MSX-2 [Ligand Id: 5610] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL413079 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
| GtoPdb | - | - | 5.6 | pKi | 2500 | nM | Ki | J Med Chem (2000) 43: 440-8 [PMID:10669571] |
| ChEMBL | Binding affinity against human adenosine A1 receptor using [3H]-CCPA (95% confidence) | B | 5.6 | pKi | 2500 | nM | Ki | J Med Chem (2000) 43: 440-448 [PMID:10669571] |
| ChEMBL | Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells | B | 5.6 | pKi | 2500 | nM | Ki | Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167] |
| ChEMBL | Binding affinity to human adenosine A1 receptor | B | 5.6 | pKi | 2500 | nM | Ki | Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167] |
| A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
| ChEMBL | Binding affinity against adenosine A1 receptor of rat brain cortical membranes using [3H]CHA | B | 6.05 | pKi | 900 | nM | Ki | J Med Chem (2000) 43: 440-448 [PMID:10669571] |
| ChEMBL | Displacement of [3H]CHA from adenosine A1 receptor in rat brain cortical membrane | B | 6.05 | pKi | 900 | nM | Ki | Eur J Med Chem (2011) 46: 3590-3607 [PMID:21664729] |
| ChEMBL | Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortex | B | 6.05 | pKi | 900 | nM | Ki | Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167] |
| ChEMBL | Binding affinity to rat adenosine A1 receptor | B | 6.05 | pKi | 900 | nM | Ki | Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167] |
| ChEMBL | Inhibition of rat recombinant adenosine A1 receptor | B | 6.05 | pKi | 900 | nM | Ki | J Med Chem (2014) 57: 3623-3650 [PMID:24164628] |
| GtoPdb | - | - | 6.05 | pKi | 900 | nM | Ki | J Med Chem (2000) 43: 440-8 [PMID:10669571] |
| A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
| ChEMBL | Binding affinity against human post-mortem brain adenosine A2A receptor using nuclei caudati and [3H]-CGS-21,680 | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2000) 43: 440-448 [PMID:10669571] |
| ChEMBL | Displacement of [3H]MSX-2 from human adenosine A2A receptor expressed in CHO cells | B | 8.27 | pKi | 5.38 | nM | Ki | Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167] |
| ChEMBL | Binding affinity to human adenosine A2A receptor | B | 8.27 | pKi | 5.38 | nM | Ki | Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167] |
| GtoPdb | - | - | 8.27 | pKi | 5.38 | nM | Ki | J Med Chem (2000) 43: 440-8 [PMID:10669571] |
| ChEMBL | Binding affinity against human adenosine A2A receptor using [3H]CGS-21680 (95% confidence) | B | 8.3 | pKi | 5 | nM | Ki | J Med Chem (2000) 43: 440-448 [PMID:10669571] |
| A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] | ||||||||
| GtoPdb | - | - | 8.09 | pKi | 8.04 | nM | Ki |
J Med Chem (2000) 43: 440-8 [PMID:10669571]; Eur J Pharm Sci (2000) 10: 259-65 [PMID:10838015] |
| ChEMBL | Displacement of [3H]MSX-2 from adenosine A2A receptor in rat brain striatum | B | 8.09 | pKi | 8.04 | nM | Ki | Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167] |
| ChEMBL | Binding affinity to rat adenosine A2A receptor | B | 8.09 | pKi | 8.04 | nM | Ki | Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167] |
| ChEMBL | Binding affinity against adenosine A2A receptor of rat brain striatal membranes using [3H]CGS-21680 | B | 8.1 | pKi | 8 | nM | Ki | J Med Chem (2000) 43: 440-448 [PMID:10669571] |
| ChEMBL | Displacement of [3H]CGS21680 from adenosine A2A receptor in rat brain striatal membrane | B | 8.1 | pKi | 8 | nM | Ki | Eur J Med Chem (2011) 46: 3590-3607 [PMID:21664729] |
| ChEMBL | Inhibition of rat recombinant adenosine receptor A2a | B | 8.3 | pKi | 5 | nM | Ki | J Med Chem (2014) 57: 3623-3650 [PMID:24164628] |
| A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
| ChEMBL | Inhibition of NECA-induced stimulation of adenylate cyclase at human adenosine A2B receptor | F | 5 | pKi | >10000 | nM | Ki | J Med Chem (2000) 43: 440-448 [PMID:10669571] |
| ChEMBL | Displacement of [3H]PSB-603 from human adenosine A2B receptor | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167] |
| ChEMBL | Binding affinity to human adenosine A2B receptor | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167] |
| ChEMBL | Inhibition of human recombinant adenosine receptor A2b | B | 5.54 | pKi | 2900 | nM | Ki | J Med Chem (2014) 57: 3623-3650 [PMID:24164628] |
| GtoPdb | - | - | 5.54 | pKi | 2900 | nM | Ki |
J Med Chem (2000) 43: 440-8 [PMID:10669571]; Psychopharmacology (Berl.) (2005) 179: 576-86 [PMID:15696333] |
| A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| GtoPdb | - | - | 5 | pKi | >10000 | nM | Ki | J Med Chem (2000) 43: 440-8 [PMID:10669571] |
| ChEMBL | Binding affinity against human adenosine A3 receptor in CHO cell membranes using [3H]NECA | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2000) 43: 440-448 [PMID:10669571] |
| ChEMBL | Displacement of [3H]PSB-11 from human adenosine A3 receptor expressed in CHO cells | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167] |
| ChEMBL | Binding affinity to human adenosine A3 receptor | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167] |
| A3 receptor/Adenosine A3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647] | ||||||||
| ChEMBL | Inhibition of rat recombinant adenosine A3 receptor | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2014) 57: 3623-3650 [PMID:24164628] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
