RWJ-56110 [Ligand Id: 3525] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL311626
  • PAR1/Proteinase-activated receptor 1 in Human [ChEMBL: CHEMBL3974] [GtoPdb: 347] [UniProtKB: P25116]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
PAR1/Proteinase-activated receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3974] [GtoPdb: 347] [UniProtKB: P25116]
ChEMBL Ability to inhibit the binding of [3H]S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cells B 6.36 pIC50 440 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 2199-2203 [PMID:12798334]
GtoPdb - - 6.36 pIC50 440 nM IC50 Proc Natl Acad Sci USA (1999) 96: 12257-62 [PMID:10535908]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]