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ChEMBL ligand: CHEMBL3233815 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Replicase polyprotein 1a in Human coronavirus NL63 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3232683] [UniProtKB: P0C6U6] | ||||||||
ChEMBL | Inhibition of human coronavirus NL63 PLP2 (amino acids 1565 to 1894) expressed in Escherichia coli BL21 (DE3) cells assessed as reduction of AMC release using Z-RLRGG-AMC as substrate by multimode plate reader analysis | B | 4.48 | pIC50 | 33000 | nM | IC50 | J Med Chem (2014) 57: 2393-2412 [PMID:24568342] |
Ubiquitin carboxyl-terminal hydrolase 20 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3232682] [UniProtKB: Q9Y2K6] | ||||||||
ChEMBL | Inhibition of human USP20 using Ub-rhodamine 110 as substrate | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2014) 57: 2393-2412 [PMID:24568342] |
ubiquitin specific peptidase 21/Ubiquitin carboxyl-terminal hydrolase 21 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2157852] [GtoPdb: 3223] [UniProtKB: Q9UK80] | ||||||||
ChEMBL | Inhibition of human USP21 using Ub-rhodamine 110 as substrate | B | 4.51 | pIC50 | >31000 | nM | IC50 | J Med Chem (2014) 57: 2393-2412 [PMID:24568342] |
ubiquitin specific peptidase 8/Ubiquitin carboxyl-terminal hydrolase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2157854] [GtoPdb: 3209] [UniProtKB: P40818] | ||||||||
ChEMBL | Inhibition of human USP8 using Ub-rhodamine 110 as substrate | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2014) 57: 2393-2412 [PMID:24568342] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]