ChEMBL ligand: CHEMBL3233815
Replicase polyprotein 1a in Human coronavirus NL63 [ChEMBL: CHEMBL3232683] [UniProtKB: P0C6U6] There should be some charts here, you may need to enable JavaScript!
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] There should be some charts here, you may need to enable JavaScript!
Ubiquitin carboxyl-terminal hydrolase 20 in Human [ChEMBL: CHEMBL3232682] [UniProtKB: Q9Y2K6] There should be some charts here, you may need to enable JavaScript!
ubiquitin specific peptidase 21/Ubiquitin carboxyl-terminal hydrolase 21 in Human [ChEMBL: CHEMBL2157852] [GtoPdb: 3223] [UniProtKB: Q9UK80] There should be some charts here, you may need to enable JavaScript!
ubiquitin specific peptidase 8/Ubiquitin carboxyl-terminal hydrolase 8 in Human [ChEMBL: CHEMBL2157854] [GtoPdb: 3209] [UniProtKB: P40818] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Replicase polyprotein 1a in Human coronavirus NL63 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3232683] [UniProtKB: P0C6U6]
ChEMBL	Inhibition of human coronavirus NL63 PLP2 (amino acids 1565 to 1894) expressed in Escherichia coli BL21 (DE3) cells assessed as reduction of AMC release using Z-RLRGG-AMC as substrate by multimode plate reader analysis	B	4.48	pIC50	33000	nM	IC50	J Med Chem (2014) 57: 2393-2412 [PMID:24568342]
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1]
ChEMBL	Inhibition of full-length SARS-CoV-2 PLpro expressed in Escherichia coli BL21(DE3) using HCC-RLRGG-NH(CH2)4NH-DABCYL probe as substrate incubated for 30 mins by enzymatic assay	B	5.58	pIC50	2640	nM	IC50	Eur J Med Chem (2022) 240: 114572-114572 [PMID:35797899]
ChEMBL	Inhibition of full-length SARS-CoV-2 PLpro expressed in Escherichia coli BL21(DE3) using Ub-Rho as substrate incubated for 5 mins by enzymatic assay	B	5.76	pIC50	1750	nM	IC50	Eur J Med Chem (2022) 240: 114572-114572 [PMID:35797899]
Ubiquitin carboxyl-terminal hydrolase 20 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3232682] [UniProtKB: Q9Y2K6]
ChEMBL	Inhibition of human USP20 using Ub-rhodamine 110 as substrate	B	4	pIC50	>100000	nM	IC50	J Med Chem (2014) 57: 2393-2412 [PMID:24568342]
ubiquitin specific peptidase 21/Ubiquitin carboxyl-terminal hydrolase 21 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2157852] [GtoPdb: 3223] [UniProtKB: Q9UK80]
ChEMBL	Inhibition of human USP21 using Ub-rhodamine 110 as substrate	B	4.51	pIC50	>31000	nM	IC50	J Med Chem (2014) 57: 2393-2412 [PMID:24568342]
ubiquitin specific peptidase 8/Ubiquitin carboxyl-terminal hydrolase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2157854] [GtoPdb: 3209] [UniProtKB: P40818]
ChEMBL	Inhibition of human USP8 using Ub-rhodamine 110 as substrate	B	4	pIC50	>100000	nM	IC50	J Med Chem (2014) 57: 2393-2412 [PMID:24568342]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]