AR-M1000390 [Ligand Id: 9005] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL415521 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
| GtoPdb | - | - | 6.97 | pKi | 106 | nM | Ki | Life Sci (2003) 73: 1691-704 [PMID:12875901] |
| GtoPdb | - | - | 9.05 | pIC50 | 0.89 | nM | IC50 | WO2006124687 A1. Opioid receptor subtype-selective agents. (2006) |
| ChEMBL | Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand. | B | 9.06 | pIC50 | 0.87 | nM | IC50 | J Med Chem (2000) 43: 3895-3905 [PMID:11052794] |
| ChEMBL | Effective concentration as delta agonist potency using [35S]GTP-gamma-S binding assay. | F | 8.14 | pEC50 | 7.2 | nM | EC50 | J Med Chem (2000) 43: 3895-3905 [PMID:11052794] |
| κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| ChEMBL | Binding affinity on cloned opioid receptor kappa 1 in human HEK293S cells using [125I]-D-Pro10-dynorphin A[1-11] as radioligand. | B | 5.13 | pIC50 | 7470 | nM | IC50 | J Med Chem (2000) 43: 3895-3905 [PMID:11052794] |
| GtoPdb | - | - | 5.13 | pIC50 | 7470 | nM | IC50 | WO2006124687 A1. Opioid receptor subtype-selective agents. (2006) |
| μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| GtoPdb | - | - | 5.42 | pIC50 | 3800 | nM | IC50 | WO2006124687 A1. Opioid receptor subtype-selective agents. (2006) |
| ChEMBL | Binding affinity on cloned opioid receptor mu 1 in human HEK293S cells using [125I]FK33824 as radioligand. | B | 5.42 | pIC50 | 3800 | nM | IC50 | J Med Chem (2000) 43: 3895-3905 [PMID:11052794] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
