AR-M1000390 [Ligand Id: 9005] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL415521 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
| GtoPdb | - | - | 6.97 | pKi | 106 | nM | Ki | Life Sci (2003) 73: 1691-704 [PMID:12875901] |
| GtoPdb | - | - | 9.05 | pIC50 | 0.89 | nM | IC50 | WO2006124687 A1. Opioid receptor subtype-selective agents. (2006) |
| ChEMBL | Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand. | B | 9.06 | pIC50 | 0.87 | nM | IC50 | J Med Chem (2000) 43: 3895-3905 [PMID:11052794] |
| ChEMBL | Effective concentration as delta agonist potency using [35S]GTP-gamma-S binding assay. | F | 8.14 | pEC50 | 7.2 | nM | EC50 | J Med Chem (2000) 43: 3895-3905 [PMID:11052794] |
| κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| ChEMBL | Binding affinity on cloned opioid receptor kappa 1 in human HEK293S cells using [125I]-D-Pro10-dynorphin A[1-11] as radioligand. | B | 5.13 | pIC50 | 7470 | nM | IC50 | J Med Chem (2000) 43: 3895-3905 [PMID:11052794] |
| GtoPdb | - | - | 5.13 | pIC50 | 7470 | nM | IC50 | WO2006124687 A1. Opioid receptor subtype-selective agents. (2006) |
| μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| GtoPdb | - | - | 5.42 | pIC50 | 3800 | nM | IC50 | WO2006124687 A1. Opioid receptor subtype-selective agents. (2006) |
| ChEMBL | Binding affinity on cloned opioid receptor mu 1 in human HEK293S cells using [125I]FK33824 as radioligand. | B | 5.42 | pIC50 | 3800 | nM | IC50 | J Med Chem (2000) 43: 3895-3905 [PMID:11052794] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
