PI1 [Ligand Id: 5814] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1801361
  • CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
There should be some charts here, you may need to enable JavaScript!
  • NPS receptor/Neuropeptide S receptor in Human [ChEMBL: CHEMBL5162] [GtoPdb: 302] [UniProtKB: Q6W5P4]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL Inhibition of CB1 receptor B 5.22 pIC50 6000 nM IC50 Bioorg Med Chem Lett (2010) 20: 4704-4708 [PMID:20615693]
NPS receptor/Neuropeptide S receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5162] [GtoPdb: 302] [UniProtKB: Q6W5P4]
GtoPdb - - 7.3 pIC50 - - - Bioorg Med Chem Lett (2010) 20: 4704-8 [PMID:20615693]
ChEMBL Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay F 7.37 pIC50 43 nM IC50 Bioorg Med Chem Lett (2010) 20: 4704-4708 [PMID:20615693]
ChEMBL Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay F 7.37 pIC50 43 nM IC50 J Med Chem (2013) 56: 9045-9056 [PMID:24171469]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]