PI1 [Ligand Id: 5814] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1801361 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
| ChEMBL | Inhibition of CB1 receptor | B | 5.22 | pIC50 | 6000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4704-4708 [PMID:20615693] |
| NPS receptor/Neuropeptide S receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5162] [GtoPdb: 302] [UniProtKB: Q6W5P4] | ||||||||
| GtoPdb | - | - | 7.3 | pIC50 | - | - | - | Bioorg Med Chem Lett (2010) 20: 4704-8 [PMID:20615693] |
| ChEMBL | Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay | F | 7.37 | pIC50 | 43 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4704-4708 [PMID:20615693] |
| ChEMBL | Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay | F | 7.37 | pIC50 | 43 | nM | IC50 | J Med Chem (2013) 56: 9045-9056 [PMID:24171469] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
