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Gene and Protein Information | ||||||
class A G protein-coupled receptor | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 7 | 371 | 7p14.3 | NPSR1 | neuropeptide S receptor 1 | 26,39,76,90 |
Mouse | 7 | 371 | 9 A3-A4 | Npsr1 | neuropeptide S receptor 1 | 55 |
Rat | 7 | 372 | 8q13 | Npsr1 | neuropeptide S receptor 1 |
Previous and Unofficial Names |
VRR1 | GPR154 | PGR14 | G protein-coupled receptor 154 | vasopressin receptor-related receptor 1 |
Database Links | |
Specialist databases | |
GPCRdb | npsr1_human (Hs), npsr1_mouse (Mm), npsr1_rat (Rn) |
Other databases | |
Alphafold | Q6W5P4 (Hs), Q8BZP8 (Mm), P0C0L6 (Rn) |
ChEMBL Target | CHEMBL5162 (Hs), CHEMBL5497 (Mm), CHEMBL3308949 (Rn) |
Ensembl Gene | ENSG00000187258 (Hs), ENSMUSG00000043659 (Mm), ENSRNOG00000015863 (Rn) |
Entrez Gene | 387129 (Hs), 319239 (Mm), 300458 (Rn) |
Human Protein Atlas | ENSG00000187258 (Hs) |
KEGG Gene | hsa:387129 (Hs), mmu:319239 (Mm), rno:300458 (Rn) |
OMIM | 608595 (Hs) |
Pharos | Q6W5P4 (Hs) |
RefSeq Nucleotide | NM_207172 (Hs), NM_175678 (Mm), NM_001106808 (Rn) |
RefSeq Protein | NP_997056 (Hs), NP_997055 (Hs), NP_783609 (Mm), NP_001100278 (Rn) |
UniProtKB | Q6W5P4 (Hs), Q8BZP8 (Mm), P0C0L6 (Rn) |
Wikipedia | NPSR1 (Hs) |
Natural/Endogenous Ligands |
neuropeptide S {Sp: Human} , neuropeptide S {Sp: Mouse} , neuropeptide S {Sp: Rat} |
Download all structure-activity data for this target as a CSV file
Agonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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View species-specific agonist tables | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Agonist Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
[125I]-Tyr10-hNPS = [125I]-Tyr10 Neuropeptide S (human). |
Antagonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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View species-specific antagonist tables | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Antagonist Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Antagonist SHA 68 has been tested against human Asn107 and Ile107 NPS receptor variants exhibiting pA2 values of 7.8 and 7.5 respectively [53]. The value for antagonist RTI-118 in the table above refers to human NPSR Ile107. The ligand has been tested also at the human NPSR Asn107 with pKe value of 6.31 [92]. NCGC 84 has also been tested in calcium mobilization and ERK phosphorylation assays where it displays pIC50 values of 7.44 and 8.03 respectively [84]. |
Primary Transduction Mechanisms | |
Transducer | Effector/Response |
Gq/G11 family | Phospholipase C stimulation |
References: 4,82,90 |
Secondary Transduction Mechanisms | |
Transducer | Effector/Response |
Gs family | Adenylyl cyclase stimulation |
References: 26,64 |
Tissue Distribution | ||||||||
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Expression Datasets | |
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Physiological Consequences of Altering Gene Expression | ||||||||||
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Physiological Consequences of Altering Gene Expression Comments | ||||||||||
NPS receptor knockout mice have been investigated in different laboratories. Of note, the anxious-like phenotype, the memory deficit and the reduced sensitivity to the hypnotic effect of diazepam and EtOH have not been replicated in other laboratories [7,20,71,94]. More importantly, the NPS stimulant [17,20,71,94] and arousal promoting [71] effects, the NPS anxiolytic-like [71,94] and anti-aggressiveness [69] actions are no longer evident in NPS receptor knockout mice. |
Phenotypes, Alleles and Disease Models | Mouse data from MGI | ||||||||||||||||||
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Clinically-Relevant Mutations and Pathophysiology | ||||||||||
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General Comments |
NPS precursor mRNA is highly expressed in a cluster of neurons located adjacent to the Locus coeruleus [90]. |
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27. Han RW, Chang M, Peng YL, Qiao LY, Yin XQ, Li W, Wang R. (2009) Central Neuropeptide S inhibits distal colonic transit through activation of central Neuropeptide S receptor in mice. Peptides, 30 (7): 1313-7. [PMID:19540430]
28. Han RW, Xu HJ, Zhang RS, Wang P, Chang M, Peng YL, Deng KY, Wang R. (2014) Neuropeptide S interacts with the basolateral amygdala noradrenergic system in facilitating object recognition memory consolidation. Neurobiol Learn Mem, 107: 32-6. [PMID:24211255]
29. Han RW, Yin XQ, Chang M, Peng YL, Li W, Wang R. (2009) Neuropeptide S facilitates spatial memory and mitigates spatial memory impairment induced by N-methyl-D-aspartate receptor antagonist in mice. Neurosci Lett, 455 (1): 74-7. [PMID:19429110]
30. Han RW, Zhang RS, Xu HJ, Chang M, Peng YL, Wang R. (2013) Neuropeptide S enhances memory and mitigates memory impairment induced by MK801, scopolamine or Aβ₁₋₄₂ in mice novel object and object location recognition tasks. Neuropharmacology, 70: 261-7. [PMID:23454528]
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48. Lukas M, Neumann ID. (2012) Nasal application of neuropeptide S reduces anxiety and prolongs memory in rats: social versus non-social effects. Neuropharmacology, 62 (1): 398-405. [PMID:21871467]
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