ALRT 1550 [Ligand Id: 2740] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL89241 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Retinoic acid receptor-α/Retinoic acid receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276] | ||||||||
| ChEMBL | Inhibition of [3H]ATRA binding to Retinoic acid receptor RAR alpha | B | 7.2 | pKi | 63.5 | nM | Ki | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Inhibition of [3H]ATRA binding to Retinoic acid receptor RAR alpha | B | 8.96 | pKi | 1.1 | nM | Ki | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR alpha | F | 7.19 | pEC50 | 65 | nM | EC50 | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR alpha | F | 8.4 | pEC50 | 4 | nM | EC50 | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| Retinoic acid receptor-β/Retinoic acid receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826] | ||||||||
| ChEMBL | Inhibition of [3H]ATRA binding to Retinoic acid receptor RAR beta | B | 7.05 | pKi | 90 | nM | Ki | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Inhibition of [3H]ATRA binding to Retinoic acid receptor RAR beta | B | 9.15 | pKi | 0.7 | nM | Ki | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta | F | 7.62 | pEC50 | 24 | nM | EC50 | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta | F | 8.66 | pEC50 | 2.2 | nM | EC50 | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631] | ||||||||
| ChEMBL | Inhibition of [3H]ATRA binding to Retinoic acid receptor RAR gamma | B | 6.91 | pKi | 124 | nM | Ki | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Inhibition of [3H]ATRA binding to Retinoic acid receptor RAR gamma | B | 8.72 | pKi | 1.9 | nM | Ki | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gamma | F | 7.8 | pEC50 | 16 | nM | EC50 | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gamma | F | 9.47 | pEC50 | 0.34 | nM | EC50 | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| Retinoid X receptor-α/Retinoid X receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793] | ||||||||
| ChEMBL | Inhibition of [3H]9-cis-RA binding to Retinoid X receptor RXR alpha | B | 6.65 | pKi | 223 | nM | Ki | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Inhibition of [3H]9-cis-RA binding to Retinoid X receptor RXR alpha | B | 8.34 | pKi | 4.6 | nM | Ki | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR alpha | F | 6.87 | pEC50 | 134 | nM | EC50 | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| Retinoid X receptor-β/Retinoid X receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1870] [GtoPdb: 611] [UniProtKB: P28702] | ||||||||
| ChEMBL | Inhibition of [3H]9-cis-RA binding to Retinoid X receptor RXR beta | B | 6.25 | pKi | 560 | nM | Ki | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Inhibition of [3H]9-cis-RA binding to Retinoid X receptor RXR beta | B | 7.99 | pKi | 10.2 | nM | Ki | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR beta | F | 7.06 | pEC50 | 87 | nM | EC50 | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| Retinoid X receptor-γ/Retinoid X receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2004] [GtoPdb: 612] [UniProtKB: P48443] | ||||||||
| ChEMBL | Inhibition of [3H]9-cis-RA binding to Retinoid X receptor RXR gamma | B | 6.49 | pKi | 320 | nM | Ki | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Inhibition of [3H]9-cis-RA binding to Retinoid X receptor RXR gamma | B | 8.03 | pKi | 9.3 | nM | Ki | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR gamma | F | 7.11 | pEC50 | 77 | nM | EC50 | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| RAR-related orphan receptor-β in Human [GtoPdb: 599] [UniProtKB: Q92753] | ||||||||
| GtoPdb | - | - | 6.8 | pKi | - | - | - | Nat Struct Biol (2003) 10: 820-5 [PMID:12958591] |
| GtoPdb | - | - | 10.4 | pIC50 | - | - | - | Nat Struct Biol (2003) 10: 820-5 [PMID:12958591] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
