PSB-0963 [Ligand Id: 9023] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL608559 (PSB-0963) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Ecto-5'-Nucleotidase/5`-nucleotidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075214] [GtoPdb: 1232] [UniProtKB: P21588] | ||||||||
| GtoPdb | - | - | 6.82 | pKi | 150 | nM | Ki | J Med Chem (2010) 53: 2076-86 [PMID:20146483] |
| ChEMBL | Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis method | B | 6.82 | pKi | 150 | nM | Ki | J Med Chem (2010) 53: 2076-2086 [PMID:20146483] |
| ectonucleoside triphosphate diphosphohydrolase 1/Ectonucleoside triphosphate diphosphohydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5722] [GtoPdb: 2888] [UniProtKB: P49961] | ||||||||
| ChEMBL | Inhibition of human NTPdase1 by capillary electrophoresis method | B | 5.59 | pKi | 2590 | nM | Ki | J Med Chem (2010) 53: 2076-2086 [PMID:20146483] |
| GtoPdb | - | - | 5.59 | pKi | 2590 | nM | Ki | J Med Chem (2010) 53: 2076-86 [PMID:20146483] |
| Ectonucleoside triphosphate diphosphohydrolase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5897] [UniProtKB: O75355] | ||||||||
| ChEMBL | Inhibition of human NTPdase3 by capillary electrophoresis method | B | 4.22 | pKi | >60000 | nM | Ki | J Med Chem (2010) 53: 2076-2086 [PMID:20146483] |
| P2Y2 receptor/Purinergic receptor P2Y2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231] | ||||||||
| ChEMBL | Antagonist activity at human P2Y2 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization | F | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2010) 53: 2076-2086 [PMID:20146483] |
| P2Y4 receptor/Pyrimidinergic receptor P2Y4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2123] [GtoPdb: 325] [UniProtKB: P51582] | ||||||||
| ChEMBL | Antagonist activity at human P2Y4 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 2076-2086 [PMID:20146483] |
| P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3543] [GtoPdb: 326] [UniProtKB: Q63371] | ||||||||
| ChEMBL | Antagonist activity at rat P2Y6 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 2076-2086 [PMID:20146483] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
