PSB-0963 [Ligand Id: 9023] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL608559 (PSB-0963) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Ecto-5'-Nucleotidase/5`-nucleotidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075214] [GtoPdb: 1232] [UniProtKB: P21588] | ||||||||
| GtoPdb | - | - | 6.82 | pKi | 150 | nM | Ki | J Med Chem (2010) 53: 2076-86 [PMID:20146483] |
| ChEMBL | Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis method | B | 6.82 | pKi | 150 | nM | Ki | J Med Chem (2010) 53: 2076-2086 [PMID:20146483] |
| ectonucleoside triphosphate diphosphohydrolase 1/Ectonucleoside triphosphate diphosphohydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5722] [GtoPdb: 2888] [UniProtKB: P49961] | ||||||||
| ChEMBL | Inhibition of human NTPdase1 by capillary electrophoresis method | B | 5.59 | pKi | 2590 | nM | Ki | J Med Chem (2010) 53: 2076-2086 [PMID:20146483] |
| GtoPdb | - | - | 5.59 | pKi | 2590 | nM | Ki | J Med Chem (2010) 53: 2076-86 [PMID:20146483] |
| Ectonucleoside triphosphate diphosphohydrolase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5897] [UniProtKB: O75355] | ||||||||
| ChEMBL | Inhibition of human NTPdase3 by capillary electrophoresis method | B | 4.22 | pKi | >60000 | nM | Ki | J Med Chem (2010) 53: 2076-2086 [PMID:20146483] |
| P2Y2 receptor/Purinergic receptor P2Y2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231] | ||||||||
| ChEMBL | Antagonist activity at human P2Y2 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization | F | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2010) 53: 2076-2086 [PMID:20146483] |
| P2Y4 receptor/Pyrimidinergic receptor P2Y4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2123] [GtoPdb: 325] [UniProtKB: P51582] | ||||||||
| ChEMBL | Antagonist activity at human P2Y4 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 2076-2086 [PMID:20146483] |
| P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3543] [GtoPdb: 326] [UniProtKB: Q63371] | ||||||||
| ChEMBL | Antagonist activity at rat P2Y6 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 2076-2086 [PMID:20146483] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
