PSB-0963 [Ligand Id: 9023] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL608559 (PSB-0963)
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  • ectonucleoside triphosphate diphosphohydrolase 1/Ectonucleoside triphosphate diphosphohydrolase 1 in Human [ChEMBL: CHEMBL5722] [GtoPdb: 2888] [UniProtKB: P49961]
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  • Ectonucleoside triphosphate diphosphohydrolase 3 in Human [ChEMBL: CHEMBL5897] [UniProtKB: O75355]
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  • P2Y2 receptor/Purinergic receptor P2Y2 in Human [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231]
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  • P2Y4 receptor/Pyrimidinergic receptor P2Y4 in Human [ChEMBL: CHEMBL2123] [GtoPdb: 325] [UniProtKB: P51582]
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  • P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Rat [ChEMBL: CHEMBL3543] [GtoPdb: 326] [UniProtKB: Q63371]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Ecto-5'-Nucleotidase/5`-nucleotidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075214] [GtoPdb: 1232] [UniProtKB: P21588]
GtoPdb - - 6.82 pKi 150 nM Ki J Med Chem (2010) 53: 2076-86 [PMID:20146483]
ChEMBL Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis method B 6.82 pKi 150 nM Ki J. Med. Chem. (2010) 53: 2076-2086 [PMID:20146483]
ectonucleoside triphosphate diphosphohydrolase 1/Ectonucleoside triphosphate diphosphohydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5722] [GtoPdb: 2888] [UniProtKB: P49961]
ChEMBL Inhibition of human NTPdase1 by capillary electrophoresis method B 5.59 pKi 2590 nM Ki J. Med. Chem. (2010) 53: 2076-2086 [PMID:20146483]
GtoPdb - - 5.59 pKi 2590 nM Ki J Med Chem (2010) 53: 2076-86 [PMID:20146483]
Ectonucleoside triphosphate diphosphohydrolase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5897] [UniProtKB: O75355]
ChEMBL Inhibition of human NTPdase3 by capillary electrophoresis method B 4.22 pKi >60000 nM Ki J. Med. Chem. (2010) 53: 2076-2086 [PMID:20146483]
P2Y2 receptor/Purinergic receptor P2Y2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231]
ChEMBL Antagonist activity at human P2Y2 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization F 5 pIC50 10000 nM IC50 J. Med. Chem. (2010) 53: 2076-2086 [PMID:20146483]
P2Y4 receptor/Pyrimidinergic receptor P2Y4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2123] [GtoPdb: 325] [UniProtKB: P51582]
ChEMBL Antagonist activity at human P2Y4 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization F 5 pIC50 >10000 nM IC50 J. Med. Chem. (2010) 53: 2076-2086 [PMID:20146483]
P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3543] [GtoPdb: 326] [UniProtKB: Q63371]
ChEMBL Antagonist activity at rat P2Y6 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization F 5 pIC50 >10000 nM IC50 J. Med. Chem. (2010) 53: 2076-2086 [PMID:20146483]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]