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ChEMBL ligand: CHEMBL608559 (PSB-0963) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Ecto-5'-Nucleotidase/5`-nucleotidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075214] [GtoPdb: 1232] [UniProtKB: P21588] | ||||||||
GtoPdb | - | - | 6.82 | pKi | 150 | nM | Ki | J Med Chem (2010) 53: 2076-86 [PMID:20146483] |
ChEMBL | Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis method | B | 6.82 | pKi | 150 | nM | Ki | J. Med. Chem. (2010) 53: 2076-2086 [PMID:20146483] |
ectonucleoside triphosphate diphosphohydrolase 1/Ectonucleoside triphosphate diphosphohydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5722] [GtoPdb: 2888] [UniProtKB: P49961] | ||||||||
ChEMBL | Inhibition of human NTPdase1 by capillary electrophoresis method | B | 5.59 | pKi | 2590 | nM | Ki | J. Med. Chem. (2010) 53: 2076-2086 [PMID:20146483] |
GtoPdb | - | - | 5.59 | pKi | 2590 | nM | Ki | J Med Chem (2010) 53: 2076-86 [PMID:20146483] |
Ectonucleoside triphosphate diphosphohydrolase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5897] [UniProtKB: O75355] | ||||||||
ChEMBL | Inhibition of human NTPdase3 by capillary electrophoresis method | B | 4.22 | pKi | >60000 | nM | Ki | J. Med. Chem. (2010) 53: 2076-2086 [PMID:20146483] |
P2Y2 receptor/Purinergic receptor P2Y2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231] | ||||||||
ChEMBL | Antagonist activity at human P2Y2 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization | F | 5 | pIC50 | 10000 | nM | IC50 | J. Med. Chem. (2010) 53: 2076-2086 [PMID:20146483] |
P2Y4 receptor/Pyrimidinergic receptor P2Y4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2123] [GtoPdb: 325] [UniProtKB: P51582] | ||||||||
ChEMBL | Antagonist activity at human P2Y4 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization | F | 5 | pIC50 | >10000 | nM | IC50 | J. Med. Chem. (2010) 53: 2076-2086 [PMID:20146483] |
P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3543] [GtoPdb: 326] [UniProtKB: Q63371] | ||||||||
ChEMBL | Antagonist activity at rat P2Y6 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization | F | 5 | pIC50 | >10000 | nM | IC50 | J. Med. Chem. (2010) 53: 2076-2086 [PMID:20146483] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]