compound 9 [PMID: 1738140] [Ligand Id: 8677] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL309130
  • Arginyl aminopeptidase/Aminopeptidase B in Human [ChEMBL: CHEMBL2432] [GtoPdb: 1564] [UniProtKB: Q9H4A4]
  • Arginyl aminopeptidase/Aminopeptidase B in Rat [ChEMBL: CHEMBL2452] [GtoPdb: 1564] [UniProtKB: O09175]
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  • Aminopeptidase A/Aspartyl aminopeptidase in Human [ChEMBL: CHEMBL2761] [GtoPdb: 1559] [UniProtKB: Q9ULA0]
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  • Leucine aminopeptidase 3/Leucine aminopeptidase in Human [ChEMBL: CHEMBL3965] [GtoPdb: 1569] [UniProtKB: P28838]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Arginyl aminopeptidase/Aminopeptidase B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2432] [GtoPdb: 1564] [UniProtKB: Q9H4A4]
ChEMBL Compound was tested for binding affinity towards arginyl aminopeptidase B 4.41 pKi 39000 nM Ki J Med Chem (1992) 35: 451-456 [PMID:1738140]
Arginyl aminopeptidase/Aminopeptidase B in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2452] [GtoPdb: 1564] [UniProtKB: O09175]
ChEMBL Inhibitory activity against aminopeptidase B B 4.41 pKi 39000 nM Ki J Med Chem (1988) 31: 2193-2199 [PMID:3184126]
Aminopeptidase N in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1907] [GtoPdb: 1560] [UniProtKB: P15144]
ChEMBL Compound was tested for binding affinity towards microsomal aminopeptidase B 4.7 pKi 20000 nM Ki J Med Chem (1992) 35: 451-456 [PMID:1738140]
Aminopeptidase N in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2590] [UniProtKB: P15145]
ChEMBL Inhibitory activity against Aminopeptidase M B 4.7 pKi 20000 nM Ki J Med Chem (1988) 31: 2193-2199 [PMID:3184126]
Aminopeptidase A/Aspartyl aminopeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2761] [GtoPdb: 1559] [UniProtKB: Q9ULA0]
GtoPdb - - 6.29 pKi 510 nM Ki J Med Chem (1992) 35: 451-6 [PMID:1738140]
ChEMBL Compound was tested for binding affinity towards cytosolic aminopeptidase B 6.29 pKi 510 nM Ki J Med Chem (1992) 35: 451-456 [PMID:1738140]
Leucine aminopeptidase 3/Leucine aminopeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3965] [GtoPdb: 1569] [UniProtKB: P28838]
ChEMBL Inhibitory activity against Leucine aminopeptidase B 6.29 pKi 510 nM Ki J Med Chem (1988) 31: 2193-2199 [PMID:3184126]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]