Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL485862 (OSIP-339391) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
ChEMBL | Antagonist activity against human adenosine A1 receptor | F | 6.35 | pKi | 450 | nM | Ki | Eur J Med Chem (2010) 45: 3459-3471 [PMID:20537438] |
ChEMBL | Binding affinity to human adenosine A1 receptor | B | 7.43 | pKi | 37 | nM | Ki | J Med Chem (2009) 52: 3994-4006 [PMID:19569717] |
ChEMBL | Binding affinity to human adenosine A1 receptor | B | 7.43 | pKi | 37 | nM | Ki | J Med Chem (2012) 55: 797-811 [PMID:22148859] |
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
ChEMBL | Binding affinity to human adenosine A2A receptor | B | 6.48 | pKi | 328 | nM | Ki | J Med Chem (2009) 52: 3994-4006 [PMID:19569717] |
ChEMBL | Antagonist activity against human adenosine A2A receptor | F | 6.48 | pKi | 328 | nM | Ki | Eur J Med Chem (2010) 45: 3459-3471 [PMID:20537438] |
ChEMBL | Binding affinity to human adenosine A2A receptor | B | 6.48 | pKi | 328 | nM | Ki | J Med Chem (2012) 55: 797-811 [PMID:22148859] |
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
GtoPdb | - | - | 9.8 | pKd | - | - | - | Biochem Pharmacol (2004) 68: 305-12 [PMID:15194002] |
ChEMBL | Antagonist activity against human adenosine A2B receptor | F | 9.3 | pKi | 0.5 | nM | Ki | Eur J Med Chem (2010) 45: 3459-3471 [PMID:20537438] |
ChEMBL | Binding affinity to human recombinant A2B receptor expressed in HEK293 cell membranes | B | 9.3 | pKi | 0.5 | nM | Ki | J Med Chem (2019) 62: 9315-9330 [PMID:31557025] |
ChEMBL | Antagonist activity at human A2B receptor | B | 9.3 | pKi | 0.5 | nM | Ki | J Med Chem (2021) 64: 458-480 [PMID:33372800] |
ChEMBL | Binding affinity to human adenosine A2B receptor | B | 9.39 | pKi | 0.41 | nM | Ki | J Med Chem (2009) 52: 3994-4006 [PMID:19569717] |
ChEMBL | Binding affinity to human adenosine A2B receptor | B | 9.4 | pKi | 0.4 | nM | Ki | J Med Chem (2012) 55: 797-811 [PMID:22148859] |
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
ChEMBL | Binding affinity to human adenosine A3 receptor | B | 6.35 | pKi | 450 | nM | Ki | J Med Chem (2009) 52: 3994-4006 [PMID:19569717] |
ChEMBL | Antagonist activity against human adenosine A3 receptor | F | 6.35 | pKi | 450 | nM | Ki | Eur J Med Chem (2010) 45: 3459-3471 [PMID:20537438] |
ChEMBL | Binding affinity to human adenosine A3 receptor | B | 6.35 | pKi | 450 | nM | Ki | J Med Chem (2012) 55: 797-811 [PMID:22148859] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]