ChEMBL ligand: CHEMBL13817 (Ibutamoren, L-163,191, MK-677)
ghrelin receptor/Ghrelin receptor in Human [ChEMBL: CHEMBL4616] [GtoPdb: 246] [UniProtKB: Q92847] ghrelin receptor/Ghrelin receptor in Rat [ChEMBL: CHEMBL3278] [GtoPdb: 246] [UniProtKB: O08725] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ghrelin receptor/Ghrelin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4616] [GtoPdb: 246] [UniProtKB: Q92847]
ChEMBL	Compound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activity	B	9.85	pKd	0.14	nM	Kd	J Med Chem (1998) 41: 3103-3127 [PMID:9703459]
GtoPdb	-	-	9.34	pKi	0.46	nM	Ki	Eur J Endocrinol (1999) 141: 180-9 [PMID:10427162]
ChEMBL	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	B	9.62	pKi	0.24	nM	Ki	J Med Chem (1996) 39: 1767-1770 [PMID:8627599]
ChEMBL	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptor	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2000) 10: 5-8 [PMID:10636230]
ChEMBL	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	B	7.49	pIC50	32	nM	IC50	J Med Chem (2003) 46: 1191-1203 [PMID:12646029]
ChEMBL	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	B	8.7	pIC50	2	nM	IC50	J Med Chem (2018) 61: 5974-5987 [PMID:29909635]
ChEMBL	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	B	8.7	pIC50	2	nM	IC50	J Med Chem (2018) 61: 5974-5987 [PMID:29909635]
ChEMBL	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	B	9.12	pIC50	0.76	nM	IC50	J Med Chem (2003) 46: 1191-1203 [PMID:12646029]
ChEMBL	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	B	9.2	pIC50	0.63	nM	IC50	Bioorg Med Chem Lett (2001) 11: 1955-1957 [PMID:11459669]
ChEMBL	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cells	B	9.29	pIC50	0.51	nM	IC50	J Med Chem (2002) 45: 5609-5616 [PMID:12477342]
ChEMBL	Inhibition against human growth hormone secretagogue (GHS) receptor	B	9.4	pIC50	0.4	nM	IC50	J Med Chem (2004) 47: 888-899 [PMID:14761190]
ChEMBL	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	F	8.84	pEC50	1.43	nM	EC50	Bioorg Med Chem Lett (2001) 11: 1955-1957 [PMID:11459669]
ChEMBL	Agonist activity at human GHS-R1	F	8.87	pEC50	1.35	nM	EC50	Bioorg Med Chem (2007) 15: 3054-3064 [PMID:17329109]
ChEMBL	Agonist activity at human GHS-R1	F	8.89	pEC50	1.3	nM	EC50	Bioorg Med Chem (2007) 15: 3054-3064 [PMID:17329109]
ChEMBL	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	F	9.4	pEC50	0.4	nM	EC50	J Med Chem (2018) 61: 5974-5987 [PMID:29909635]
ChEMBL	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	F	9.4	pEC50	0.4	nM	EC50	J Med Chem (2018) 61: 5974-5987 [PMID:29909635]
ChEMBL	Agonist activity at GHSR (unknown origin)	B	9.7	pEC50	0.2	nM	EC50	J Med Chem (2013) 56: 1197-1210 [PMID:23281966]
GtoPdb	-	-	9.72	pEC50	0.19	nM	EC50	Mol Endocrinol (2005) 19: 2400-11 [PMID:15905359]; Eur J Endocrinol (1999) 141: 180-9 [PMID:10427162]
ghrelin receptor/Ghrelin receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3278] [GtoPdb: 246] [UniProtKB: O08725]
ChEMBL	In vitro growth hormone release was determined in rat pituitary cell assay	F	8.89	pEC50	1.3	nM	EC50	Bioorg Med Chem Lett (1998) 8: 107-112 [PMID:9925440]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]