puquitinib

Ligand id: 9928

Name: puquitinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 91.41
Molecular weight 317.14
XLogP 2.71
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N'-cyclopropyl-N-quinolin-6-yl-7H-purine-2,6-diamine
Synonyms
XC-302 | XC302
Comments
Puquitinib is an orally active, PI3 kinase inhibitor that induces autophagy by inhibiting the PI3K/AKT/mTOR signaling pathway. Puquitinib is selective for p110δ relative to other PI3K class I enzymes. It is a clinical lead developed for antitumour activity [3].
Puquitinib is a 'pseudo' INN, that takes the form of an INN, but has not been submitted to the World Health Organisation for ratification.
Database Links
GtoPdb PubChem SID 363894222
PubChem CID 15983184
Search Google for chemical match using the InChIKey QUTFBURLXCODBH-UHFFFAOYSA-N
Search Google for chemicals with the same backbone QUTFBURLXCODBH
Search UniChem for chemical match using the InChIKey QUTFBURLXCODBH-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone QUTFBURLXCODBH