cyclic GMP [Ligand Id: 2347] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL395336 (cyclic GMP) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Phosphodiesterase 3B in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5129] [UniProtKB: E1BN64] | ||||||||
| ChEMBL | Inhibition of bovine arterial Phosphodiesterase 3 | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (1996) 39: 297-303 [PMID:8568820] |
| CNGA1 in Human [GtoPdb: 394] [UniProtKB: P29973] | ||||||||
| GtoPdb | - | - | 4.22 | pKi | 60000 | nM | Ki |
Neuron (2002) 36: 891-6 [PMID:12467592]; Neuron (1995) 14: 177-83 [PMID:7530019]; J Neurosci (1992) 12: 3248-56 [PMID:1379636]; Proc Natl Acad Sci USA (1995) 92: 10177-81 [PMID:7479749]; Biophys J (1998) 74: 1333-45 [PMID:9512030]; Proc Natl Acad Sci USA (1994) 91: 11757-61 [PMID:7526403]; J Gen Physiol (1999) 113: 17-34 [PMID:9874685] |
| CNGA2 in Rat [GtoPdb: 395] [UniProtKB: Q00195] | ||||||||
| GtoPdb | - | - | 5.76 | pEC50 | 1740 | nM | EC50 |
Neuron (1994) 13: 611-21 [PMID:7522482]; Proc Natl Acad Sci USA (1994) 91: 8890-4 [PMID:7522325]; Sci Signal (2012) 5: ra48 [PMID:22786723] |
| CNGA3 in Human [GtoPdb: 396] [UniProtKB: Q16281] | ||||||||
| GtoPdb | - | - | 5.6 | pKd | - | - | - |
FEBS Lett (1996) 393: 211-5 [PMID:8814292]; Eur J Neurosci (1997) 9: 2512-21 [PMID:9517456]; J Biol Chem (2003) 278: 24617-23 [PMID:12730238] |
| CNGA3 in Rat [GtoPdb: 396] | ||||||||
| GtoPdb | - | - | 5.51 | pKd | - | - | - | J Neurophysiol (2001) 85: 2335-49 [PMID:11387380] |
| HCN2 in Mouse [GtoPdb: 401] [UniProtKB: O88703] | ||||||||
| GtoPdb | - | - | 5.2 | pKi | - | - | - | Nature (1998) 393: 587-91 [PMID:9634236] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
