tertatolol [Ligand Id: 571] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL434200 (Artex, Artexal, Prenalex, S-2395, SE-2395, Tertatolol, Tertatolol hydrochloride) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
| ChEMBL | The compound was evaluated for binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampal membranes using [3H]8-OH-DPAT as radioligand in the presence of 3*10e-5 M GTP gamma S | B | 7.42 | pKi | 37.6 | nM | Ki | Bioorg Med Chem Lett (1993) 3: 2035-2038 |
| ChEMBL | Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement | B | 7.73 | pKi | 18.62 | nM | Ki | J Med Chem (1996) 39: 126-134 [PMID:8568799] |
| ChEMBL | Displacement of [3H]8-OH-DPAT from rat hippocampal 5-hydroxytryptamine 1A receptor | B | 7.74 | pKi | 18.2 | nM | Ki | Bioorg Med Chem Lett (1993) 3: 2035-2038 |
| ChEMBL | The compound was evaluated for binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampal membranes using [3H]8-OH-DPAT as radioligand in the presence of 1 mM of MnCl2 | B | 8.11 | pKi | 7.71 | nM | Ki | Bioorg Med Chem Lett (1993) 3: 2035-2038 |
| β3-adrenoceptor in Human [GtoPdb: 30] [UniProtKB: P13945] | ||||||||
| GtoPdb | - | - | 8.6 | pKi | - | - | - | Eur J Pharmacol (2004) 484: 323-31 [PMID:14744619] |
| β3-adrenoceptor in Mouse [GtoPdb: 30] [UniProtKB: P25962] | ||||||||
| GtoPdb | - | - | 7 | pKi | - | - | - | Eur J Pharmacol (2004) 484: 323-31 [PMID:14744619] |
| β3-adrenoceptor in Rat [GtoPdb: 30] [UniProtKB: P26255] | ||||||||
| GtoPdb | - | - | 7 | pKi | - | - | - | Eur J Pharmacol (2004) 484: 323-31 [PMID:14744619] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
