galectin 9   Click here for help

GtoPdb Ligand ID: 9594

Synonyms: Ecalectin | Gal-9 | Tumor antigen HOM-HD-21
Immunopharmacology Ligand
Comment: Galectin 9 is a secreted lectin that is an endogenous ligand of the immune co-inhibitory receptor, TIM3. Galectins bind β-galactoside sugar modifications on proteins, and have been associated with metastasis and immunosuppression. Galectin 9 contains two tandem carbohydrate recognition domains (CRD) within its peptide structure. The CRDs are homologous but distinct in their primary sequence. The whole peptide sequence provided here is for the longest isoform reported to date. Uniprot records 6 human protein isoforms [2-3]. Isoform 2 is known as ecalectin, and is reported to be a novel eosinophil chemoattractant produced by T lymphocytes [1,4-5,7]. The regulation and function of galectin 9 in physiological and pathological conditions was reviewed by Hirashima et al. (2004) [6].
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Galectins
Synonyms Click here for help
Ecalectin | Gal-9 | Tumor antigen HOM-HD-21
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
LGALS9 galectin 9 Human galectin-9 isoform long -
Database Links Click here for help
GtoPdb PubChem SID 340590225
UniProtKB O00182 (Hs)