GtoPdb Ligand ID: 7343

Synonyms: AMG-145 | AMG145 | NN7415 | Repatha®
evolocumab is an approved drug (EMA & FDA (2015))
Compound class: Antibody
Comment: Evolocumab is a clinically approved anti-PCSK9 (proprotein convertase subtilisin/kexin type 9) monoclonal antibody. Peptide sequences for this antibody are available from its IMGT/mAb-DB link. The development and discovery of this antibody is described in patent US8030457, where SEQ IDs 23 and 49 comprising clone 21B12 light and heavy chain variable regions respectively, match the peptide sequences in the INN record for evolocumab.
Compound class Antibody
Approved drug? Yes (EMA & FDA (2015))
International Nonproprietary Names
INN number INN
9643 evolocumab
AMG-145 | AMG145 | NN7415 | Repatha®
Database Links
Specialist databases
IMGT/mAb-DB 448 (Hs)
Other databases
CAS Registry No. 1256937-27-5 (source: Scifinder)
GtoPdb PubChem SID 178103915
PubChem SID 178103915
Search PubMed clinical trials evolocumab
Search PubMed titles evolocumab
Search PubMed titles/abstracts evolocumab
Wikipedia Evolocumab