ChEMBL ligand: CHEMBL69257
D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] There should be some charts here, you may need to enable JavaScript!
Serotonin 4 (5-HT4) receptor in Guinea pig [ChEMBL: CHEMBL5017] [UniProtKB: O70528] There should be some charts here, you may need to enable JavaScript!
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] There should be some charts here, you may need to enable JavaScript!
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL	Compound was evaluated for its ability to displace [3H]spiperone binding from Dopamine receptor D2 in rat striatum.	B	6.98	pKi	104.71	nM	Ki	J Med Chem (1999) 42: 533-535 [PMID:10052959]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL	Compound was evaluated for its ability to displace [3H]8-OH-DPAT binding from human 5-hydroxytryptamine 1A receptor in mammalian cells	B	6.77	pKi	169.82	nM	Ki	J Med Chem (1999) 42: 533-535 [PMID:10052959]
ChEMBL	Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	B	6.77	pKi	169	nM	Ki	Eur J Med Chem (2014) 85: 716-726 [PMID:25128671]
ChEMBL	Antagonist activity at 5-HT1A receptor (unknown origin)	B	6.77	pKi	169	nM	Ki	Eur J Med Chem (2019) 183: 111705-111705 [PMID:31581003]
Serotonin 4 (5-HT4) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
ChEMBL	Compound was evaluated for its ability to displace [3H]GR-113808 binding from 5-hydroxytryptamine 4 receptor in guinea pig striatum.	B	6	pKi	<1000	nM	Ki	J Med Chem (1999) 42: 533-535 [PMID:10052959]
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL	Compound was evaluated for its ability to displace [3H]LSD binding from human recombinant 5-hydroxytryptamine 6 receptor	B	6.28	pKi	524.81	nM	Ki	J Med Chem (1999) 42: 533-535 [PMID:10052959]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
ChEMBL	Binding affinity to 5HT7 receptor	B	8.48	pKi	3.31	nM	Ki	Bioorg Med Chem Lett (2010) 20: 1118-1123 [PMID:20022748]
ChEMBL	Binding affinity to 5-HT7 receptor (unknown origin)	B	8.67	pKi	2.14	nM	Ki	J Med Chem (2018) 61: 8475-8503 [PMID:29767995]
ChEMBL	Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method	B	8.67	pKi	2.14	nM	Ki	Bioorg Med Chem Lett (2018) 28: 2418-2421 [PMID:29910079]
ChEMBL	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	B	8.67	pKi	2.14	nM	Ki	Eur J Med Chem (2014) 85: 716-726 [PMID:25128671]
ChEMBL	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	B	8.67	pKi	2.14	nM	Ki	Bioorg Med Chem (2012) 20: 1545-1556 [PMID:22277589]
ChEMBL	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	B	8.67	pKi	2.14	nM	Ki	J Med Chem (2002) 45: 2197-2206 [PMID:12014957]
ChEMBL	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	B	8.67	pKi	2.14	nM	Ki	J Med Chem (1999) 42: 533-535 [PMID:10052959]
ChEMBL	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	B	8.67	pKi	2.14	nM	Ki	Bioorg Med Chem Lett (2003) 13: 61-64 [PMID:12467617]
ChEMBL	Antagonist activity at 5-HT7 receptor (unknown origin)	B	8.67	pKi	2.13	nM	Ki	Eur J Med Chem (2019) 183: 111705-111705 [PMID:31581003]
ChEMBL	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	B	8.68	pKi	2.1	nM	Ki	Bioorg Med Chem Lett (2002) 12: 2451-2454 [PMID:12161155]
ChEMBL	Binding affinity towards human 5-hydroxytryptamine 7 receptor	B	8.7	pKi	2	nM	Ki	J Med Chem (2003) 46: 2795-2812 [PMID:12825922]
GtoPdb	-	-	8.7	pKi	2	nM	Ki	J Med Chem (1999) 42: 533-5 [PMID:10052959]; J Med Chem (2003) 46: 2795-812 [PMID:12825922]
ChEMBL	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	B	8.7	pKi	2	nM	Ki	J Med Chem (2000) 43: 342-345 [PMID:10669560]
ChEMBL	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	B	8.7	pKi	2	nM	Ki	J Med Chem (2003) 46: 5638-5650 [PMID:14667218]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305]
ChEMBL	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	B	7.3	pKi	50.12	nM	Ki	J Med Chem (2003) 46: 5638-5650 [PMID:14667218]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]