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dinutuximab   Click here for help

GtoPdb Ligand ID: 7979

Synonyms: APN-311 | Ch14.18 | MAb-14.18 | Unituxin®
Approved drug
dinutuximab is an approved drug (FDA (2015))
Compound class: Antibody
Comment: Dinutuximab is a chimeric mouse/human monoclonal antibody targeting ganglioside-GD2.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
A patent search identifies US20140170155 [4] as the applicable patent. US20140170155 reveals APN311 as a formulation of the mouse-human chimeric anti-GD2 antibody ch14.18 recombinantly produced in Chinese hamster ovary (CHO) cells. Efficacy of the preferred antibody was determined by its cytolysis capacity in GD2-expressing cells, as determined by a complement dependent cytolysis assay.
Classification Click here for help
Compound class Antibody
Approved drug? Yes. US FDA (2015)
International Nonproprietary Names Click here for help
INN number INN
9754 dinutuximab
Synonyms Click here for help
APN-311 | Ch14.18 | MAb-14.18 | Unituxin®
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 464
Other databases
GtoPdb PubChem SID 249565662
Search PubMed clinical trials dinutuximab
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Wikipedia Dinutuximab