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ChEMBL ligand: CHEMBL1394231 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Erythrocyte urea transporter/Urea transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2390814] [GtoPdb: 982] [UniProtKB: Q13336] | ||||||||
ChEMBL | Inhibition of UT-B in human erythrocytes assessed as increase of hypotonic lysis | B | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3338-3341 [PMID:23597791] |
GtoPdb | - | - | 7.96 | pIC50 | ~11 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3338-41 [PMID:23597791] |
Erythrocyte urea transporter/Urea transporter 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2163171] [GtoPdb: 982] [UniProtKB: Q8VHL0] | ||||||||
GtoPdb | - | - | 7.6 | pIC50 | 25 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3338-41 [PMID:23597791] |
ChEMBL | Reversible inhibition of mouse UT-B-mediated urea transport | B | 7.6 | pIC50 | 25.1 | nM | IC50 | J Med Chem (2012) 55: 5942-5950 [PMID:22694147] |
ChEMBL | Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 mins | B | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (2012) 55: 5942-5950 [PMID:22694147] |
ChEMBL | Inhibition of UT-B in mouse acetamide-loaded erythrocyte assessed as increase of hypotonic lysis | B | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3338-3341 [PMID:23597791] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]