compound 1a [PMID: 23597791] [Ligand Id: 8881] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1394231
  • Erythrocyte urea transporter/Urea transporter 1 in Human [ChEMBL: CHEMBL2390814] [GtoPdb: 982] [UniProtKB: Q13336]
  • Erythrocyte urea transporter/Urea transporter 1 in Mouse [ChEMBL: CHEMBL2163171] [GtoPdb: 982] [UniProtKB: Q8VHL0]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Erythrocyte urea transporter/Urea transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2390814] [GtoPdb: 982] [UniProtKB: Q13336]
ChEMBL Inhibition of UT-B in human erythrocytes assessed as increase of hypotonic lysis B 7.96 pIC50 11 nM IC50 Bioorg Med Chem Lett (2013) 23: 3338-3341 [PMID:23597791]
GtoPdb - - 7.96 pIC50 ~11 nM IC50 Bioorg Med Chem Lett (2013) 23: 3338-41 [PMID:23597791]
Erythrocyte urea transporter/Urea transporter 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2163171] [GtoPdb: 982] [UniProtKB: Q8VHL0]
GtoPdb - - 7.6 pIC50 25 nM IC50 Bioorg Med Chem Lett (2013) 23: 3338-41 [PMID:23597791]
ChEMBL Reversible inhibition of mouse UT-B-mediated urea transport B 7.6 pIC50 25.1 nM IC50 J Med Chem (2012) 55: 5942-5950 [PMID:22694147]
ChEMBL Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 mins B 7.96 pIC50 11 nM IC50 J Med Chem (2012) 55: 5942-5950 [PMID:22694147]
ChEMBL Inhibition of UT-B in mouse acetamide-loaded erythrocyte assessed as increase of hypotonic lysis B 7.96 pIC50 11 nM IC50 Bioorg Med Chem Lett (2013) 23: 3338-3341 [PMID:23597791]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]