sulpiride [Ligand Id: 5501] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL26 (N05AL01, Dogmatyl, Dolmatil, RD-1403, Sulpiride)
  • AGAP002992-PA in Anopheles gambiae [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56]
  • This target only has 1 pki data point
1 CHEMBL26_lig_chart_1 AGAP002992-PA Anopheles gambiae
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  • α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
  • This target only has 1 pki data point
2 CHEMBL26_lig_chart_2 Alpha-2a adrenergic receptor Human
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  • Alpha carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02]
3 CHEMBL26_lig_chart_3 Alpha carbonic anhydrase Stylophora pistillata
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  • Astrosclerin-3 in Astrosclera willeyana [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1]
  • This target only has 1 pki data point
4 CHEMBL26_lig_chart_4 Astrosclerin-3 Astrosclera willeyana
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  • Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3]
  • This target only has 1 pki data point
5 CHEMBL26_lig_chart_5 Carbonate dehydratase Sulfurihydrogenibium sp. (strain YO3AOP1)
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  • Carbonic anhydrase in Mycobacterium tuberculosis [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9]
  • Carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24]
  • Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71]
  • Carbonic anhydrase in Candida glabrata CBS 138 [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6]
  • Carbonic anhydrase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL5931] [UniProtKB: P53615]
6 CHEMBL26_lig_chart_6 Carbonic anhydrase Mycobacterium tuberculosisStylophora pistillataCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)Candida glabrata CBS 138Saccharomyces cerevisiae S288c
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  • Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) [ChEMBL: CHEMBL4211] [UniProtKB: O24855]
7 CHEMBL26_lig_chart_7 Carbonic anhydrase 1 Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori)
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  • Carbonic anhydrase 15 in Mouse [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23]
  • This target only has 1 pki data point
8 CHEMBL26_lig_chart_8 Carbonic anhydrase 15 Mouse
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  • Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7]
  • This target only has 1 pki data point
9 CHEMBL26_lig_chart_9 Carbonic anhydrase 2 Cryptococcus neoformans var. grubii
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  • Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6]
  • This target only has 1 pki data point
10 CHEMBL26_lig_chart_10 Carbonic anhydrase, alpha family Thiomicrospira crunogena (strain XCL-2)
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  • carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
11 CHEMBL26_lig_chart_11 Carbonic anhydrase I Human
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  • carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
12 CHEMBL26_lig_chart_12 Carbonic anhydrase II Human
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  • Carbonic anhydrase III in Human [ChEMBL: CHEMBL2885] [UniProtKB: P07451]
  • This target only has 1 pki data point
13 CHEMBL26_lig_chart_13 Carbonic anhydrase III Human
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  • Carbonic anhydrase IV in Bovine [ChEMBL: CHEMBL281] [UniProtKB: Q95323]
  • This target only has 0 pki data point
14 CHEMBL26_lig_chart_14 Carbonic anhydrase IV Bovine
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  • carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
15 CHEMBL26_lig_chart_15 Carbonic anhydrase IX Human
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  • carbonic anhydrase 5A/Carbonic anhydrase VA in Human [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
  • This target only has 1 pki data point
16 CHEMBL26_lig_chart_16 Carbonic anhydrase VA Human
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  • Carbonic anhydrase VB in Human [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0]
  • This target only has 1 pki data point
17 CHEMBL26_lig_chart_17 Carbonic anhydrase VB Human
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18 CHEMBL26_lig_chart_18 Carbonic anhydrase VI Human
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  • carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
19 CHEMBL26_lig_chart_19 Carbonic anhydrase VII Human
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  • carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
20 CHEMBL26_lig_chart_20 Carbonic anhydrase XII Human
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  • Delta carbonic anhydrase in Thalassiosira weissflogii [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1]
  • This target only has 1 pki data point
21 CHEMBL26_lig_chart_21 Delta carbonic anhydrase Thalassiosira weissflogii
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  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
  • Dopamine D2 receptor in Dog [ChEMBL: CHEMBL2703] [UniProtKB: Q9GJU1]
  • D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
22 CHEMBL26_lig_chart_22 Dopamine D2 receptor HumanDogRat
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  • D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
23 CHEMBL26_lig_chart_23 Dopamine D3 receptor Human
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  • D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
  • This target only has 1 pki data point
24 CHEMBL26_lig_chart_24 Dopamine D4 receptor Human
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  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
  • This target only has 0 pki data point
25 CHEMBL26_lig_chart_25 Sigma opioid receptor Human
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  • Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7]
  • This target only has 1 pki data point
26 CHEMBL26_lig_chart_26 Uncharacterized protein Rv1284/MT1322 Mycobacterium tuberculosis
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
AGAP002992-PA in Anopheles gambiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56]
ChEMBL Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay B 7.53 pKi 29.5 nM Ki Bioorg. Med. Chem. (2015) 23: 2303-2309 [PMID:25882523]
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) B 6.12 pKi 757 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) B 5.69 pIC50 2019 nM IC50 DrugMatrix in vitro pharmacology data
Alpha carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02]
ChEMBL Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay B 6.37 pKi 430 nM Ki Bioorg. Med. Chem. (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay B 6.37 pKi 430 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 710-714 [PMID:21208801]
Astrosclerin-3 in Astrosclera willeyana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1]
ChEMBL Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay B 6.42 pKi 378 nM Ki Bioorg. Med. Chem. (2012) 20: 1403-1410 [PMID:22285172]
Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3]
ChEMBL Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay B 7.17 pKi 67.4 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 401-405 [PMID:26691758]
Carbonic anhydrase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9]
ChEMBL Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay B 6.58 pKi 266 nM Ki Bioorg. Med. Chem. Lett. (2009) 19: 6649-6654 [PMID:19846301]
Carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24]
ChEMBL Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay B 6.38 pKi 415 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 710-714 [PMID:21208801]
Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71]
ChEMBL Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay B 6.12 pKi 760 nM Ki Bioorg. Med. Chem. (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method B 6.12 pKi 760 nM Ki J. Med. Chem. (2012) 55: 3513-3520 [PMID:22424239]
Carbonic anhydrase in Candida glabrata CBS 138 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6]
ChEMBL Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay B 6.95 pKi 113 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 2647-2652 [PMID:23511020]
Carbonic anhydrase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5931] [UniProtKB: P53615]
ChEMBL Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay B 6.91 pKi 124 nM Ki Bioorg. Med. Chem. (2009) 17: 1158-1163 [PMID:19124253]
Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4211] [UniProtKB: O24855]
ChEMBL Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay B 6.69 pKi 204 nM Ki J. Med. Chem. (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL Inhibition of Helicobacter pylori recombinant CA B 6.75 pKi 179 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 2182-2188 [PMID:16459077]
Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23]
ChEMBL Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay B 7.14 pKi 73 nM Ki J. Med. Chem. (2009) 52: 646-654 [PMID:19193158]
Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7]
ChEMBL Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method B 6.09 pKi 812 nM Ki J. Med. Chem. (2012) 55: 3513-3520 [PMID:22424239]
Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6]
ChEMBL Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay B 6.06 pKi 873 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 401-405 [PMID:26691758]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay B 4.92 pKi 12000 nM Ki Bioorg. Med. Chem. (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay B 4.92 pKi 12000 nM Ki J. Med. Chem. (2009) 52: 646-654 [PMID:19193158]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay B 4.92 pKi 12000 nM Ki J. Med. Chem. (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay B 4.92 pKi 12000 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 5485-5489 [PMID:26525863]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase method B 4.92 pKi 12000 nM Ki Bioorg. Med. Chem. (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL Inhibition of human recombinant CA1 by stopped-flow CO2 assay B 4.92 pKi 12000 nM Ki Bioorg. Med. Chem. (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay B 4.92 pKi 12000 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 710-714 [PMID:21208801]
ChEMBL Inhibition of human recombinant cytosolic isozyme CA I by stopped-flow CO2 hydrase method B 4.92 pKi 12000 nM Ki J. Med. Chem. (2007) 50: 381-388 [PMID:17228881]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method B 4.92 pKi 12000 nM Ki J. Med. Chem. (2009) 52: 2226-2232 [PMID:19317447]
GtoPdb - - 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 963-9 [PMID:15686894]
ChEMBL Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay B 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. (2013) 21: 5168-5174 [PMID:23867389]
ChEMBL Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay B 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay B 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay B 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. (2014) 22: 2939-2946 [PMID:24792813]
ChEMBL Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method B 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. (2014) 22: 4537-4543 [PMID:25129169]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay B 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. (2015) 23: 526-531 [PMID:25533402]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay B 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. (2015) 23: 1728-1734 [PMID:25773015]
ChEMBL Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay B 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. (2015) 23: 2303-2309 [PMID:25882523]
ChEMBL Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay B 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 401-405 [PMID:26691758]
ChEMBL Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay B 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. (2016) 24: 1115-1120 [PMID:26850377]
ChEMBL Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay B 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 1821-1826 [PMID:26920803]
ChEMBL Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis B 5.92 pKi 1200 nM Ki Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002]
ChEMBL Ki value against human carbonic anhydrase I (hCA I) B 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 963-969 [PMID:15686894]
ChEMBL Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay B 5.92 pKi 1200 nM Ki Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay B 5.92 pKi 1200 nM Ki J. Med. Chem. (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL Inhibition of human recombinant CA1 B 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 2182-2188 [PMID:16459077]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay B 5.92 pKi 1200 nM Ki J. Med. Chem. (2006) 49: 5544-5551 [PMID:16942027]
ChEMBL Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5 B 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. (2011) 19: 1172-1178 [PMID:21251841]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay B 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay B 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. (2012) 20: 1403-1410 [PMID:22285172]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay B 5.92 pKi 1200 nM Ki J. Med. Chem. (2013) 56: 1761-1771 [PMID:23391336]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay B 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. (2013) 21: 1534-1538 [PMID:22883029]
ChEMBL Inhibitory activity of compound against human carbonic anhydrase I F 5.92 pIC50 1200 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 337-341 [PMID:14698154]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL Ki value against human carbonic anhydrase II (hCA II) B 7.4 pKi 40 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 963-969 [PMID:15686894]
ChEMBL Inhibitory activity against human recombinant cytosolic CA2 B 7.4 pKi 40 nM Ki J. Med. Chem. (2005) 48: 7860-7866 [PMID:16302824]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay B 7.4 pKi 40 nM Ki J. Med. Chem. (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL Inhibition of human recombinant CA2 B 7.4 pKi 40 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 2182-2188 [PMID:16459077]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay B 7.4 pKi 40 nM Ki J. Med. Chem. (2006) 49: 5544-5551 [PMID:16942027]
ChEMBL Inhibition of human recombinant cytosolic isozyme CA II by stopped-flow CO2 hydrase method B 7.4 pKi 40 nM Ki J. Med. Chem. (2007) 50: 381-388 [PMID:17228881]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method B 7.4 pKi 40 nM Ki J. Med. Chem. (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay B 7.4 pKi 40 nM Ki Bioorg. Med. Chem. (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay B 7.4 pKi 40 nM Ki J. Med. Chem. (2009) 52: 646-654 [PMID:19193158]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay B 7.4 pKi 40 nM Ki J. Med. Chem. (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay B 7.4 pKi 40 nM Ki Bioorg. Med. Chem. (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL Inhibition of human recombinant CA2 by stopped-flow CO2 assay B 7.4 pKi 40 nM Ki Bioorg. Med. Chem. (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL Inhibition of human recombinant CA2 by stopped-flow hydration assay B 7.4 pKi 40 nM Ki Bioorg. Med. Chem. Lett. (2009) 19: 6649-6654 [PMID:19846301]
ChEMBL Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay B 7.4 pKi 40 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 710-714 [PMID:21208801]
ChEMBL Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5 B 7.4 pKi 40 nM Ki Bioorg. Med. Chem. (2011) 19: 1172-1178 [PMID:21251841]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay B 7.4 pKi 40 nM Ki Bioorg. Med. Chem. (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay B 7.4 pKi 40 nM Ki Bioorg. Med. Chem. (2012) 20: 1403-1410 [PMID:22285172]
ChEMBL Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method B 7.4 pKi 40 nM Ki J. Med. Chem. (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay B 7.4 pKi 40 nM Ki J. Med. Chem. (2013) 56: 1761-1771 [PMID:23391336]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay B 7.4 pKi 40 nM Ki Bioorg. Med. Chem. (2013) 21: 1534-1538 [PMID:22883029]
ChEMBL Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay B 7.4 pKi 40 nM Ki Bioorg. Med. Chem. (2013) 21: 5168-5174 [PMID:23867389]
ChEMBL Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay B 7.4 pKi 40 nM Ki Bioorg. Med. Chem. (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay B 7.4 pKi 40 nM