sulpiride [Ligand Id: 5501] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL26 (Dogmatyl, Dolmatil, N05AL01, NSC-757850, RD-1403, Sulpiride) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| AGAP002992-PA in Anopheles gambiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56] | ||||||||
| ChEMBL | Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.53 | pKi | 29.5 | nM | Ki | Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523] |
| α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913] | ||||||||
| ChEMBL | DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) | B | 6.12 | pKi | 757 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) | B | 5.69 | pIC50 | 2019 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Alpha carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02] | ||||||||
| ChEMBL | Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay | B | 6.37 | pKi | 430 | nM | Ki | Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577] |
| ChEMBL | Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay | B | 6.37 | pKi | 430 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| Astrosclerin-3 in Astrosclera willeyana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1] | ||||||||
| ChEMBL | Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay | B | 6.42 | pKi | 378 | nM | Ki | Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172] |
| Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3] | ||||||||
| ChEMBL | Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay | B | 7.17 | pKi | 67.4 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| Carbonic anhydrase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9] | ||||||||
| ChEMBL | Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay | B | 6.58 | pKi | 266 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301] |
| Carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24] | ||||||||
| ChEMBL | Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 6.38 | pKi | 415 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71] | ||||||||
| ChEMBL | Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay | B | 6.12 | pKi | 760 | nM | Ki | Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983] |
| ChEMBL | Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method | B | 6.12 | pKi | 760 | nM | Ki | J Med Chem (2012) 55: 3513-3520 [PMID:22424239] |
| Carbonic anhydrase in Candida glabrata CBS 138 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6] | ||||||||
| ChEMBL | Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay | B | 6.95 | pKi | 113 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 2647-2652 [PMID:23511020] |
| Carbonic anhydrase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5931] [UniProtKB: P53615] | ||||||||
| ChEMBL | Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay | B | 6.91 | pKi | 124 | nM | Ki | Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253] |
| Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4211] [UniProtKB: O24855] | ||||||||
| ChEMBL | Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay | B | 6.69 | pKi | 204 | nM | Ki | J Med Chem (2006) 49: 2117-2126 [PMID:16539401] |
| ChEMBL | Inhibition of Helicobacter pylori recombinant CA | B | 6.75 | pKi | 179 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077] |
| Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23] | ||||||||
| ChEMBL | Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay | B | 7.14 | pKi | 73 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7] | ||||||||
| ChEMBL | Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method | B | 6.09 | pKi | 812 | nM | Ki | J Med Chem (2012) 55: 3513-3520 [PMID:22424239] |
| Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6] | ||||||||
| ChEMBL | Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay | B | 6.06 | pKi | 873 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay | B | 4.92 | pKi | 12000 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay | B | 4.92 | pKi | 12000 | nM | Ki | J Med Chem (2009) 52: 3116-3120 [PMID:19338333] |
| ChEMBL | Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | B | 4.92 | pKi | 12000 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase method | B | 4.92 | pKi | 12000 | nM | Ki | Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped-flow CO2 assay | B | 4.92 | pKi | 12000 | nM | Ki | Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay | B | 4.92 | pKi | 12000 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| ChEMBL | Inhibition of human recombinant cytosolic isozyme CA I by stopped-flow CO2 hydrase method | B | 4.92 | pKi | 12000 | nM | Ki | J Med Chem (2007) 50: 381-388 [PMID:17228881] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method | B | 4.92 | pKi | 12000 | nM | Ki | J Med Chem (2009) 52: 2226-2232 [PMID:19317447] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay | B | 4.92 | pKi | 12000 | nM | Ki | Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253] |
| GtoPdb | - | - | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 963-9 [PMID:15686894] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184] |
| ChEMBL | Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813] |
| ChEMBL | Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| ChEMBL | Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002] |
| ChEMBL | Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911] |
| ChEMBL | Ki value against human carbonic anhydrase I (hCA I) | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894] |
| ChEMBL | Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assay | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay | B | 5.92 | pKi | 1200 | nM | Ki | J Med Chem (2006) 49: 2117-2126 [PMID:16539401] |
| ChEMBL | Inhibition of human recombinant CA1 | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay | B | 5.92 | pKi | 1200 | nM | Ki | J Med Chem (2006) 49: 5544-5551 [PMID:16942027] |
| ChEMBL | Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5 | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay | B | 5.92 | pKi | 1200 | nM | Ki | J Med Chem (2013) 56: 1761-1771 [PMID:23391336] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029] |
| ChEMBL | Inhibitory activity of compound against human carbonic anhydrase I | F | 5.92 | pIC50 | 1200 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 337-341 [PMID:14698154] |
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Ki value against human carbonic anhydrase II (hCA II) | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894] |
| ChEMBL | Inhibitory activity against human recombinant cytosolic CA2 | B | 7.4 | pKi | 40 | nM | Ki | J Med Chem (2005) 48: 7860-7866 [PMID:16302824] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay | B | 7.4 | pKi | 40 | nM | Ki | J Med Chem (2006) 49: 2117-2126 [PMID:16539401] |
| ChEMBL | Inhibition of human recombinant CA2 | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay | B | 7.4 | pKi | 40 | nM | Ki | J Med Chem (2006) 49: 5544-5551 [PMID:16942027] |
| ChEMBL | Inhibition of human recombinant cytosolic isozyme CA II by stopped-flow CO2 hydrase method | B | 7.4 | pKi | 40 | nM | Ki | J Med Chem (2007) 50: 381-388 [PMID:17228881] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method | B | 7.4 | pKi | 40 | nM | Ki | J Med Chem (2009) 52: 2226-2232 [PMID:19317447] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay | B | 7.4 | pKi | 40 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay | B | 7.4 | pKi | 40 | nM | Ki | J Med Chem (2009) 52: 3116-3120 [PMID:19338333] |
| ChEMBL | Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow CO2 assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow hydration assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| ChEMBL | Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5 | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method | B | 7.4 | pKi | 40 | nM | Ki | J Med Chem (2012) 55: 3513-3520 [PMID:22424239] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay | B | 7.4 | pKi | 40 | nM | Ki | J Med Chem (2013) 56: 1761-1771 [PMID:23391336] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184] |
| ChEMBL | Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813] |
| ChEMBL | Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 3550-3555 [PMID:26174556] |
| ChEMBL | Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| ChEMBL | Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1253-1259 [PMID:26832216] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002] |
| ChEMBL | Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387] |
| ChEMBL | Inhibitory activity of compound against human carbonic anhydrase II | F | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 337-341 [PMID:14698154] |
| Carbonic anhydrase III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451] | ||||||||
| ChEMBL | Inhibition of human recombinant CA 3 assessed as CO2 hydration by stopped flow kinetic assay | B | 4.97 | pKi | 10600 | nM | Ki | Bioorg Med Chem (2007) 15: 7229-7236 [PMID:17826101] |
| Carbonic anhydrase IV in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL281] [UniProtKB: Q95323] | ||||||||
| ChEMBL | Inhibitory activity of compound against bovine carbonic anhydrase IV | F | 6.21 | pIC50 | 620 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 337-341 [PMID:14698154] |
| carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibition of catalytic domain of human recombinant CA IX | B | 7.34 | pKi | 46 | nM | Ki | J Med Chem (2007) 50: 381-388 [PMID:17228881] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay | B | 7.34 | pKi | 46 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human membrane bound carbonic anhydrase 9 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 7.34 | pKi | 46 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human transmembrane carbonic anhydrase 9 by stopped-flow CO2 hydration assay | B | 7.34 | pKi | 46 | nM | Ki | Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 9 by stopped-flow CO2 hydrase assay | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (2006) 49: 5544-5551 [PMID:16942027] |
| carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] | ||||||||
| ChEMBL | Inhibitory activity against human recombinant mitochondrial isozyme CA VA | B | 6.76 | pKi | 174 | nM | Ki | J Med Chem (2005) 48: 7860-7866 [PMID:16302824] |
| Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] | ||||||||
| ChEMBL | Inhibitory activity against human recombinant mitochondrial isozyme CA VB | B | 7.74 | pKi | 18 | nM | Ki | J Med Chem (2005) 48: 7860-7866 [PMID:16302824] |
| Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280] | ||||||||
| ChEMBL | Inhibition of full length human recombinant CA VI | B | 9.1 | pKi | 0.8 | nM | Ki | J Med Chem (2007) 50: 381-388 [PMID:17228881] |
| ChEMBL | Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay | B | 9.1 | pKi | 0.8 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assay | B | 9.1 | pKi | 0.8 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
| GtoPdb | - | - | 5.44 | pKi | 3630 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-82 [PMID:23965175] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 5.44 | pKi | 3630 | nM | Ki | Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 5.44 | pKi | 3630 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 8.44 | pKi | 3.6 | nM | Ki | Eur J Med Chem (2014) 71: 105-111 [PMID:24287559] |
| carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
| ChEMBL | Ki value against human carbonic anhydrase XII (hCA XII) | B | 8.41 | pKi | 3.9 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894] |
| ChEMBL | Inhibition of human membrane bound carbonic anhydrase 12 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 8.41 | pKi | 3.9 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human transmembrane carbonic anhydrase 12 by stopped-flow CO2 hydration assay | B | 8.41 | pKi | 3.9 | nM | Ki | Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184] |
| GtoPdb | - | - | 8.41 | pKi | 3.9 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 963-9 [PMID:15686894] |
| Delta carbonic anhydrase in Thalassiosira weissflogii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1] | ||||||||
| ChEMBL | Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay | B | 6.59 | pKi | 259 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394] |
| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Competitive antagonist activity at D2 long receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of dopamine induced beta-arrestin recruitment after 90 mins by DiscoveRx PathHunter assay | B | 8.55 | pKd | 2.82 | nM | Kd | J Med Chem (2017) 60: 1478-1494 [PMID:28186762] |
| ChEMBL | Binding affinity for human dopamine receptor D2 long | B | 6.92 | pKi | 120 | nM | Ki | J Med Chem (2005) 48: 694-709 [PMID:15689154] |
| ChEMBL | DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) | B | 7.17 | pKi | 68 | nM | Ki | DrugMatrix in vitro pharmacology data |
| GtoPdb | - | - | 7.92 | pKi | 12 | nM | Ki | Neuropsychopharmacology (1995) 12: 335-45 [PMID:7576010] |
| ChEMBL | Antagonist activity at dopamine D2 receptor (unknown origin) | B | 8.12 | pKi | 7.6 | nM | Ki | Medchemcomm (2011) 2: 935-941 |
| ChEMBL | DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) | B | 6.69 | pIC50 | 205 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ChEMBL | Antagonist activity at human dopamine D2 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis | F | 7.99 | pIC50 | 10.28 | nM | IC50 | J Med Chem (2011) 54: 3581-3594 [PMID:21495689] |
| Dopamine D2 receptor in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2703] [UniProtKB: Q9GJU1] | ||||||||
| ChEMBL | The IC50 value was reported as apparent, since [3H]NCA was purported to be irreversible (dopamine receptor from Canine striatal membranes). Result indicates the mean of two separate experiments, each performed in triplicate. | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (1984) 27: 806-810 [PMID:6737423] |
| D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
| ChEMBL | Affinity constant of compound was evaluated in rat striatum tissue preparation. | B | 8.82 | pKd | 1.5 | nM | Kd | J Med Chem (1988) 31: 1039-1043 [PMID:2966245] |
| ChEMBL | Binding affinity which represents concentration giving half-maximal inhibition of [3H]spiperone (Dopamine receptor D2) binding to rat tissue homogenate | B | 6.62 | pKi | 240 | nM | Ki | J Med Chem (1998) 41: 3763-3772 [PMID:9748351] |
| ChEMBL | Compound was tested for its ability to displace [3H]- spiperone from Dopamine receptor D2 in rat striatal membranes | B | 8.26 | pKi | 5.51 | nM | Ki | J Med Chem (1989) 32: 874-880 [PMID:2522993] |
| ChEMBL | In vitro binding affinity at Dopamine receptor D2 in rat by displacing [3H]- spiperone from rat striatal membrane | B | 6.63 | pIC50 | 233 | nM | IC50 | J Med Chem (1985) 28: 1263-1269 [PMID:4040977] |
| ChEMBL | Tested in vitro for inhibition of [3H]spiperone binding to dopamine receptor D2 | B | 6.68 | pIC50 | 210 | nM | IC50 | J Med Chem (1993) 36: 3417-3423 [PMID:7901417] |
| ChEMBL | Inhibition of [3H](S)-sulpiride binding in striatal homogenates of rat brain | B | 7.44 | pIC50 | 36 | nM | IC50 | J Med Chem (1988) 31: 2027-2033 [PMID:3172140] |
| ChEMBL | Inhibition of 0.1 nM of [125I]- (S)-N-(1-Ethyl-pyrrolidin-2-ylmethyl)-5-iodo-2-methoxy-benzamide binding in striatal homogenates of rat brain | B | 7.48 | pIC50 | 33 | nM | IC50 | J Med Chem (1988) 31: 2027-2033 [PMID:3172140] |
| D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
| ChEMBL | Competitive antagonist activity at D3 receptor (unknown origin) expressed in CHOK1 cells assessed as induction of rightward shift in the dopamine dose response curve for beta-arrestin recruitment after 90 mins by DiscoveRx PathHunter assay | B | 7.4 | pKd | 39.81 | nM | Kd | J Med Chem (2017) 60: 1478-1494 [PMID:28186762] |
| ChEMBL | Binding affinity for human dopamine receptor D3 | B | 6.92 | pKi | 120 | nM | Ki | J Med Chem (2005) 48: 694-709 [PMID:15689154] |
| ChEMBL | DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) | B | 7.24 | pKi | 57 | nM | Ki | DrugMatrix in vitro pharmacology data |
| GtoPdb | - | - | 7.85 | pKi | 14 | nM | Ki | Neuropsychopharmacology (1995) 12: 335-45 [PMID:7576010] |
| ChEMBL | Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cells | B | 8.1 | pKi | 8 | nM | Ki | J Med Chem (2003) 46: 4377-4392 [PMID:14521403] |
| ChEMBL | Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay | F | 6.25 | pIC50 | 560 | nM | IC50 | J Med Chem (2011) 54: 3581-3594 [PMID:21495689] |
| ChEMBL | DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) | B | 6.77 | pIC50 | 169 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ChEMBL | Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis | F | 7.18 | pIC50 | 66.22 | nM | IC50 | J Med Chem (2011) 54: 3581-3594 [PMID:21495689] |
| D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
| ChEMBL | Binding affinity for Dopamine receptor D4 | B | 5.68 | pKi | 2100 | nM | Ki | J Med Chem (2005) 48: 694-709 [PMID:15689154] |
| sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] | ||||||||
| ChEMBL | Inhibition of specific binding of [125I]PIPAG to sigma receptor in Guinea pig brain membranes | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (1992) 35: 4683-4689 [PMID:1469697] |
| ChEMBL | Inhibition of specific binding of [3H]NANM of sigma receptor in Guinea pig brain membranes | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (1992) 35: 4683-4689 [PMID:1469697] |
| Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7] | ||||||||
| ChEMBL | Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase 1 encoded by Rv1284 by stopped flow CO2 hydration assay | B | 5.64 | pKi | 2300 | nM | Ki | J Med Chem (2009) 52: 3116-3120 [PMID:19338333] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
