Nrf2 peptide [PMID: 23647822]   Click here for help

GtoPdb Ligand ID: 8772

Comment: This Nrf2 peptide displaces the longer labeled Nrf2 mimetic peptide NH2-LQLDEETGEFLPIQGK(MR121)-OH from the central cavity of the Kelch-DC domain at the C-terminus of Keap1 (Kelch-like ECH-associated protein 1; KEAP1) [1]. This article by Marcotte et al. (2013) also describes small molecule inhibitors of the Nrf2-Keap1 interaction e.g. Cpd16 (PubChem CID 1073725) binds Keap1 Kelch-DC with an IC50 of 2.7 µM [1].
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Classification Click here for help
Compound class Peptide or derivative
Database Links Click here for help
ChEMBL Ligand CHEMBL2402205
GtoPdb PubChem SID 252827430
PubChem CID 73355065