compound 13r [PMID: 23639540] [Ligand Id: 8144] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2385596 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| activin A receptor type 1/Activin receptor type-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771] | ||||||||
| GtoPdb | - | - | 8.3 | pIC50 | <5 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-52 [PMID:23639540] |
| ChEMBL | Inhibition of ALK2 (unknown origin) | B | 8.3 | pIC50 | <5 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| activin A receptor type 1B/Activin receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5310] [GtoPdb: 1787] [UniProtKB: P36896] | ||||||||
| ChEMBL | Inhibition of ALK4 (unknown origin) | B | 6.74 | pIC50 | 183 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| GtoPdb | - | - | 6.74 | pIC50 | 183 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-52 [PMID:23639540] |
| protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase, beta-1 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3847] [GtoPdb: 1543] [UniProtKB: Q9Y478] | ||||||||
| ChEMBL | Inhibition of AMPK (unknown origin) | B | 6.02 | pIC50 | 960 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| Bone morphogenetic protein 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2384894] [UniProtKB: P21275] | ||||||||
| ChEMBL | Inhibition of BMP4 in mouse C2C12BRA cells after 14 hrs by luciferase reporter gene assay | B | 7.6 | pIC50 | 25.2 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| bone morphogenetic protein receptor type IA/Bone morphogenetic protein receptor type-1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5275] [GtoPdb: 1786] [UniProtKB: P36894] | ||||||||
| GtoPdb | - | - | 8.3 | pIC50 | <5 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-52 [PMID:23639540] |
| ChEMBL | Inhibition of ALK3 (unknown origin) | B | 8.3 | pIC50 | <5 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| bone morphogenetic protein receptor type IB/Bone morphogenetic protein receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5476] [GtoPdb: 1789] [UniProtKB: O00238] | ||||||||
| GtoPdb | - | - | 8.3 | pIC50 | <5 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-52 [PMID:23639540] |
| ChEMBL | Inhibition of ALK6 (unknown origin) | B | 8.3 | pIC50 | <5 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| bone morphogenetic protein receptor type 2/Bone morphogenetic protein receptor type-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5467] [GtoPdb: 1794] [UniProtKB: Q13873] | ||||||||
| ChEMBL | Inhibition of BMPR2 (unknown origin) | B | 5.63 | pIC50 | 2360 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| activin A receptor type IL/Serine/threonine-protein kinase receptor R3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5311] [GtoPdb: 1784] [UniProtKB: P37023] | ||||||||
| GtoPdb | - | - | 8.3 | pIC50 | <5 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-52 [PMID:23639540] |
| ChEMBL | Inhibition of ALK1 (unknown origin) | B | 8.3 | pIC50 | <5 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| transforming growth factor beta receptor 1/TGF-beta receptor type I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897] | ||||||||
| GtoPdb | - | - | 7.12 | pIC50 | 75 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-52 [PMID:23639540] |
| ChEMBL | Inhibition of ALK5 (unknown origin) | B | 7.12 | pIC50 | 75 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| transforming growth factor beta receptor 2/TGF-beta receptor type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173] | ||||||||
| ChEMBL | Inhibition of TGFBR2 (unknown origin) | B | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| ChEMBL | Inhibition of KDR (unknown origin) | B | 5.82 | pIC50 | 1520 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
