ChEMBL ligand: CHEMBL195008 (Necrostatin, Necrostatin-1)
indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase in Human [ChEMBL: CHEMBL4685] [GtoPdb: 2829] [UniProtKB: P14902] There should be some charts here, you may need to enable JavaScript!
receptor interacting serine/threonine kinase 1/Receptor-interacting serine/threonine-protein kinase 1 in Human [ChEMBL: CHEMBL5464] [GtoPdb: 2189] [UniProtKB: Q13546] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4685] [GtoPdb: 2829] [UniProtKB: P14902]
ChEMBL	Competitive inhibition of 6His-tagged human recombinant IDO expressed in Escherichia coli BL21DE3pLys	B	4.92	pKi	12000	nM	Ki	J Med Chem (2015) 58: 9421-9437 [PMID:25970480]
ChEMBL	Inhibition of recombinant human IDO1 by colorimetric method	B	4.94	pKi	11600	nM	Ki	Medchemcomm (2019) 10: 1740-1754 [PMID:32055299]
GtoPdb	Using a purified recombinant human IDO enzyme for in vitro>/i> assays.	-	4.94	pKi	11600	nM	Ki	Nat Med (2005) 11: 312-9 [PMID:15711557]
ChEMBL	Inhibition of human recombinant IDO assessed as inhibition of indoleamine 2,3-dioxygenase to kynurenine conversion after 60 mins by HPLC analysis	B	4.94	pKi	11400	nM	Ki	Bioorg Med Chem (2013) 21: 1159-1165 [PMID:23337802]
ChEMBL	Inhibition of IDO1 (unknown origin)	B	4.94	pKi	11400	nM	Ki	J Med Chem (2015) 58: 8762-8782 [PMID:26207924]
ChEMBL	Inhibition of IDO1 (unknown origin)	B	4.94	pKi	11400	nM	Ki	Eur J Med Chem (2017) 138: 199-211 [PMID:28667875]
ChEMBL	Inhibition of IDO (unknown origin)	B	4	pIC50	100000	nM	IC50	J Med Chem (2020) 63: 1490-1510 [PMID:31622096]
ChEMBL	Inhibition of human recombinant IDO assessed as inhibition of indoleamine 2,3-dioxygenase to kynurenine conversion after 60 mins by HPLC analysis	B	4.11	pIC50	76900	nM	IC50	Bioorg Med Chem (2013) 21: 1159-1165 [PMID:23337802]
ChEMBL	Inhibition of recombinant human IDO1 expressed in COS1 cells by colorimetric method	B	4.89	pIC50	12850	nM	IC50	Medchemcomm (2019) 10: 1740-1754 [PMID:32055299]
ChEMBL	Inhibition of recombinant human IDO using L-Trp as substrate incubated for 60 mins	B	6.96	pIC50	110	nM	IC50	J Med Chem (2020) 63: 1490-1510 [PMID:31622096]
receptor interacting serine/threonine kinase 1/Receptor-interacting serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5464] [GtoPdb: 2189] [UniProtKB: Q13546]
ChEMBL	Inhibition of recombinant GST-tagged RIP1 (unknown origin) after 4 hrs by ADP-Glo kinase assay	B	6.12	pIC50	760	nM	IC50	J Med Chem (2017) 60: 972-986 [PMID:27992216]
GtoPdb	Measuring inhibition of cellular necrosis in TNFα-treated FADD-deficient Jurkat cells.	-	6.31	pIC50	490	nM	IC50	Nat Chem Biol (2008) 4: 313-21 [PMID:18408713]
ChEMBL	Inhibition of recombinant human GST-fused RIPK1 (1 to 497 residues) expressed in baculovirus infected insect Sf9 cells in presence of 32P-gamma-ATP after 30 mins by autoradiogram-based Western blot method	B	6.74	pIC50	182	nM	IC50	Nat Rev Drug Discov (2017) 16: 424-440 [PMID:28280261]
ChEMBL	Inhibition of endogenous RIP1 autophosphorylation in human Jurkat cells	B	6.74	pEC50	182	nM	EC50	Nat Chem Biol (2008) 4: 313-321 [PMID:18408713]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]