pexacerfont [Ligand Id: 10379] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL482950 (Bms562086, BMS-562086, Pexacerfont, CRF1 ANTAGONIST)
  • A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
  • This target only has 1 pki data point
  • 5.58
1 CHEMBL482950_lig_chart_1 Adenosine A1 receptor Rat
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  • Corticotropin-releasing factor-binding protein in Human [ChEMBL: CHEMBL5930] [UniProtKB: P24387]
  • This target only has 0 pki data point
  • 0
2 CHEMBL482950_lig_chart_2 Corticotropin-releasing factor-binding protein Human
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  • CRF1 receptor/Corticotropin releasing factor receptor 1 in Human [ChEMBL: CHEMBL1800] [GtoPdb: 212] [UniProtKB: P34998]
  • CRF1 receptor/Corticotropin releasing factor receptor 1 in Rat [ChEMBL: CHEMBL4649] [GtoPdb: 212] [UniProtKB: P35353]
  • This target only has 0 pki data point
  • 0
3 CHEMBL482950_lig_chart_3 Corticotropin releasing factor receptor 1 HumanRat
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  • CRF2 receptor/Corticotropin releasing factor receptor 2 in Human [ChEMBL: CHEMBL4069] [GtoPdb: 213] [UniProtKB: Q13324]
  • This target only has 0 pki data point
  • 0
4 CHEMBL482950_lig_chart_4 Corticotropin releasing factor receptor 2 Human
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  • NK2 receptor/Neurokinin 2 receptor in Human [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452]
  • This target only has 0 pki data point
  • 0
5 CHEMBL482950_lig_chart_5 Neurokinin 2 receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL Binding affinity to rat adenosine A1 receptor expressed in CHO cells B 5.58 pKi 2660 nM Ki J. Med. Chem. (2009) 52: 3084-3092 [PMID:19361209]
Corticotropin-releasing factor-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5930] [UniProtKB: P24387]
ChEMBL Binding affinity to human recombinant CRF binding protein B 6 pIC50 >1000 nM IC50 J. Med. Chem. (2009) 52: 3084-3092 [PMID:19361209]
ChEMBL Binding affinity to CRF-binding protein (unknown origin) B 6 pIC50 >1000 nM IC50 Drug Metab. Dispos. (2012) 40: 1093-1103 [PMID:22381334]
CRF1 receptor/Corticotropin releasing factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1800] [GtoPdb: 212] [UniProtKB: P34998]
ChEMBL Displacement of ovine [125-I]-CRF from human CRF1 receptor expressed in CHO cell membranes preincubated for 1 hr followed by compound washout for 2 hrs and subsequent addition of [125I]-CRF measured after 1 hr by liquid scintillation counting method B 5 pIC50 >10000 nM IC50 Bioorg Med Chem (2017) 25: 1556-1570 [PMID:28174066]
ChEMBL Displacement of ovine [125-I]-CRF from human CRF1 receptor expressed in CHO cell membranes preincubated for 1 hr followed by [125I]-CRF addition measured after 1 hr by liquid scintillation counting method B 6.47 pIC50 340 nM IC50 Bioorg Med Chem (2017) 25: 1556-1570 [PMID:28174066]
GtoPdb Displacement of ovine [125-I]-CRF from human CRF1 receptor expressed in CHO cell membranes. - 6.47 pIC50 340 nM IC50 Bioorg Med Chem (2017) 25: 1556-1570 [PMID:28174066]
ChEMBL Antagonist activity at human CRF1 receptor B 8.21 pIC50 6.1 nM IC50 Drug Metab. Dispos. (2012) 40: 1093-1103 [PMID:22381334]
ChEMBL Displacement of [125I]Tyr0-ovine CRF from CRF1 receptor in human IMR32 cells B 8.35 pIC50 4.5 nM IC50 J. Med. Chem. (2009) 52: 3084-3092 [PMID:19361209]
CRF1 receptor/Corticotropin releasing factor receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4649] [GtoPdb: 212] [UniProtKB: P35353]
ChEMBL Antagonist activity at CRF1 receptor in rat pituitary cells assessed as inhibition of CRF-mediated ACTH production F 6.89 pIC50 129 nM IC50 J. Med. Chem. (2009) 52: 3084-3092 [PMID:19361209]
GtoPdb Antagonism of CRF-mediated ACTH production in rat pituitary cells. - 6.89 pIC50 129 nM IC50 Bioorg Med Chem (2017) 25: 1556-1570 [PMID:28174066]
ChEMBL Displacement of [125I]Tyro-rat/human CRF from CRF1 receptor in rat cortical membrane by gamma counting B 8.21 pIC50 6.1 nM IC50 J. Med. Chem. (2009) 52: 3084-3092 [PMID:19361209]
ChEMBL Displacement of [125I]-sauvagine from rat CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation counting B 8.21 pIC50 6.1 nM IC50 J. Med. Chem. (2011) 54: 4187-4206 [PMID:21618986]
CRF2 receptor/Corticotropin releasing factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4069] [GtoPdb: 213] [UniProtKB: Q13324]
ChEMBL Displacement of [125I]Tyr0-sauvagine from CRF2beta receptor expressed in pig choroid plexus membrane B 6 pIC50 >1000 nM IC50 J. Med. Chem. (2009) 52: 3084-3092 [PMID:19361209]
NK2 receptor/Neurokinin 2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452]
ChEMBL Binding affinity to human neurokinin 2 receptor B 5.31 pIC50 4900 nM IC50 J. Med. Chem. (2009) 52: 3084-3092 [PMID:19361209]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]