cefadroxil [Ligand Id: 4831] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1644 (Cefadroxil/cefadroxil hemihydrate, Ultracef, Cefadroxil, Cefadrops, Cefatabs, BL-S578, MJF 11567-3, MJF-11567-3, Duricef, Cefadroxil monohydrate, Baxan)
  • Peptide transporter 2/Oligopeptide transporter, kidney isoform in Rat [ChEMBL: CHEMBL3325] [GtoPdb: 985] [UniProtKB: Q63424]
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  • Peptide transporter 2/Solute carrier family 15 member 2 in Human [ChEMBL: CHEMBL1743125] [GtoPdb: 985] [UniProtKB: Q16348]
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  • Organic anion transporter 1/Solute carrier family 22 member 6 in Human [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8]
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  • Organic anion transporter 3/Solute carrier family 22 member 8 in Human [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Peptide transporter 2/Oligopeptide transporter, kidney isoform in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3325] [GtoPdb: 985] [UniProtKB: Q63424]
ChEMBL TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in SKPT cells F 5.52 pKi 3000 nM Ki Eur. J. Pharm. Biopharm. (2005) 59: 17-24 [PMID:15567297]
ChEMBL TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT2-expressing LLC-PK1 cells F 5.52 pKi 3000 nM Ki Am. J. Physiol. (1997) 273: F706-F711 [PMID:9374833]
Peptide transporter 2/Solute carrier family 15 member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743125] [GtoPdb: 985] [UniProtKB: Q16348]
ChEMBL TP_TRANSPORTER: inhibition of Gly-Sar uptake in SKPT cells F 5.55 pKi 2800 nM Ki J. Biol. Chem. (1995) 270: 25672-25677 [PMID:7592745]
ChEMBL TP_TRANSPORTER: inhibition of Chephalexin uptake in SKPT cells F 5.6 pKi 2500 nM Ki J. Biol. Chem. (1995) 270: 25672-25677 [PMID:7592745]
ChEMBL TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 50 uM) in PEPT2-expressing HeLa cells F 4.18 pIC50 66000 nM IC50 J. Biol. Chem. (1995) 270: 25672-25677 [PMID:7592745]
Organic anion transporter 1/Solute carrier family 22 member 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8]
ChEMBL TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells F 5.21 pKi 6140 nM Ki Eur. J. Pharmacol. (2002) 438: 137-142 [PMID:11909604]
Organic anion transporter 3/Solute carrier family 22 member 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7]
ChEMBL TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells F 5.06 pKi 8620 nM Ki Eur. J. Pharmacol. (2002) 438: 137-142 [PMID:11909604]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]