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ChEMBL ligand: CHEMBL27246 (3-Phenylacrylic Acid, Cinnamic Acid, (E)-Cinnamic Acid, E-Cinnamic Acid, Trans-Cinnamic Acid) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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3-oxoacyl-[acyl-carrier-protein] synthase 3 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795135] [UniProtKB: C3TDZ2] | ||||||||
ChEMBL | Inhibition of N-terminal His-tagged Escherichia coli FabH expressed in Escherichia coli BL21 (DE3) using [3H]acetyl-coA after 25 mins by liquid scintillation counting | B | 4.36 | pIC50 | 43400 | nM | IC50 | Bioorg Med Chem (2011) 19: 4513-4519 [PMID:21741250] |
Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067] | ||||||||
ChEMBL | Inhibition of human amyloid beta (1 to 42) aggregation after 24 hrs by thioflavin-T fluorescence assay | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2012) 20: 5844-5849 [PMID:22921742] |
HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4] | ||||||||
ChEMBL | Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting | B | 5.31 | pKi | 4900 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 2736-2739 [PMID:21167710] |
GtoPdb | - | - | 3.62 | pEC50 | 240000 | nM | EC50 | J Lipid Res (2009) 50: 908-14 [PMID:19136666] |
phosphomevalonate kinase in Rat [GtoPdb: 641] [UniProtKB: Q5RK24] | ||||||||
GtoPdb | extracted from rat liver, in vitro assay | - | 2.42 | pKi | 3850000 | nM | Ki | Biochem J (1979) 181: 143-51 [PMID:226078] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]