ChEMBL ligand: CHEMBL27246 (3-Phenylacrylic Acid, Cinnamic Acid, (E)-Cinnamic Acid, E-Cinnamic Acid, Trans-Cinnamic Acid)
3-oxoacyl-[acyl-carrier-protein] synthase 3 in Escherichia coli [ChEMBL: CHEMBL1795135] [UniProtKB: C3TDZ2] There should be some charts here, you may need to enable JavaScript!
Amyloid-beta A4 protein in Human [ChEMBL: CHEMBL2487] [UniProtKB: P05067] There should be some charts here, you may need to enable JavaScript!
calcium/calmodulin-dependent protein kinase II alpha subunit/CaM kinase II alpha in Human [ChEMBL: CHEMBL4147] [GtoPdb: 1555] [UniProtKB: Q9UQM7] There should be some charts here, you may need to enable JavaScript!
HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4] There should be some charts here, you may need to enable JavaScript!
phosphomevalonate kinase in Rat [GtoPdb: 641] [UniProtKB: Q5RK24] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
3-oxoacyl-[acyl-carrier-protein] synthase 3 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795135] [UniProtKB: C3TDZ2]
ChEMBL	Inhibition of N-terminal His-tagged Escherichia coli FabH expressed in Escherichia coli BL21 (DE3) using [3H]acetyl-coA after 25 mins by liquid scintillation counting	B	4.36	pIC50	43400	nM	IC50	Bioorg Med Chem (2011) 19: 4513-4519 [PMID:21741250]
Amyloid-beta A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL	Inhibition of human amyloid beta (1 to 42) aggregation after 24 hrs by thioflavin-T fluorescence assay	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem (2012) 20: 5844-5849 [PMID:22921742]
calcium/calmodulin-dependent protein kinase II alpha subunit/CaM kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4147] [GtoPdb: 1555] [UniProtKB: Q9UQM7]
ChEMBL	Inhibition of [3H]NCS-382 binding to CaMK2alpha (unknown origin)	B	4	pKi	>100000	nM	Ki	J Med Chem (2022) 65: 6656-6676 [PMID:35500061]
HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4]
ChEMBL	Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting	B	5.31	pKi	4900	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2736-2739 [PMID:21167710]
GtoPdb	-	-	3.62	pEC50	240000	nM	EC50	J Lipid Res (2009) 50: 908-14 [PMID:19136666]
phosphomevalonate kinase in Rat [GtoPdb: 641] [UniProtKB: Q5RK24]
GtoPdb	extracted from rat liver, in vitro assay	-	2.42	pKi	3850000	nM	Ki	Biochem J (1979) 181: 143-51 [PMID:226078]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]