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ChEMBL ligand: CHEMBL27246 (3-Phenylacrylic Acid, Cinnamic Acid, (E)-Cinnamic Acid, E-Cinnamic Acid, Trans-Cinnamic Acid) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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3-oxoacyl-[acyl-carrier-protein] synthase 3 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795135] [UniProtKB: C3TDZ2] | ||||||||
ChEMBL | Inhibition of N-terminal His-tagged Escherichia coli FabH expressed in Escherichia coli BL21 (DE3) using [3H]acetyl-coA after 25 mins by liquid scintillation counting | B | 4.36 | pIC50 | 43400 | nM | IC50 | Bioorg Med Chem (2011) 19: 4513-4519 [PMID:21741250] |
Amyloid-beta A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067] | ||||||||
ChEMBL | Inhibition of human amyloid beta (1 to 42) aggregation after 24 hrs by thioflavin-T fluorescence assay | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2012) 20: 5844-5849 [PMID:22921742] |
calcium/calmodulin-dependent protein kinase II alpha subunit/CaM kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4147] [GtoPdb: 1555] [UniProtKB: Q9UQM7] | ||||||||
ChEMBL | Inhibition of [3H]NCS-382 binding to CaMK2alpha (unknown origin) | B | 4 | pKi | >100000 | nM | Ki | J Med Chem (2022) 65: 6656-6676 [PMID:35500061] |
HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4] | ||||||||
ChEMBL | Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting | B | 5.31 | pKi | 4900 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 2736-2739 [PMID:21167710] |
GtoPdb | - | - | 3.62 | pEC50 | 240000 | nM | EC50 | J Lipid Res (2009) 50: 908-14 [PMID:19136666] |
phosphomevalonate kinase in Rat [GtoPdb: 641] [UniProtKB: Q5RK24] | ||||||||
GtoPdb | extracted from rat liver, in vitro assay | - | 2.42 | pKi | 3850000 | nM | Ki | Biochem J (1979) 181: 143-51 [PMID:226078] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]