cinnamic acid [Ligand Id: 3203] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL27246 (E-Cinnamic Acid, 3-Phenylacrylic Acid, (E)-Cinnamic Acid, Trans-Cinnamic Acid, Cinnamic Acid)
  • 3-oxoacyl-[acyl-carrier-protein] synthase 3 in Escherichia coli [ChEMBL: CHEMBL1795135] [UniProtKB: C3TDZ2]
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  • HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4]
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  • phosphomevalonate kinase in Rat [GtoPdb: 641] [UniProtKB: Q5RK24]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
3-oxoacyl-[acyl-carrier-protein] synthase 3 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795135] [UniProtKB: C3TDZ2]
ChEMBL Inhibition of N-terminal His-tagged Escherichia coli FabH expressed in Escherichia coli BL21 (DE3) using [3H]acetyl-coA after 25 mins by liquid scintillation counting B 4.36 pIC50 43400 nM IC50 Bioorg. Med. Chem. (2011) 19: 4513-4519 [PMID:21741250]
Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL Inhibition of human amyloid beta (1 to 42) aggregation after 24 hrs by thioflavin-T fluorescence assay B 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. (2012) 20: 5844-5849 [PMID:22921742]
HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4]
ChEMBL Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting B 5.31 pKi 4900 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 2736-2739 [PMID:21167710]
GtoPdb - - 3.62 pEC50 240000 nM EC50 J Lipid Res (2009) 50: 908-14 [PMID:19136666]
phosphomevalonate kinase in Rat [GtoPdb: 641] [UniProtKB: Q5RK24]
GtoPdb extracted from rat liver, in vitro assay - 2.42 pKi 3850000 nM Ki Biochem J (1979) 181: 143-51 [PMID:226078]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]