Synonyms: 1314 TH | Bayer 5312 | Trecator®
ethionamide is an approved drug (FDA (1965))
Compound class:
Synthetic organic
Comment: Ethionamide is a thioamide compound with potent antibacterial activity against mycobacteria. It is a prodrug that requires intracellular activation, by the monooxygenase EthA, in Mycobacterium tuberculosis [1]. Ethionamide is used in the treatment of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB).
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Classification | |
Compound class | Synthetic organic |
Approved drug? | Yes (FDA (1965)) |
WHO Essential Medicine | WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version. Click to view more information about the WHO Model Lists of Essential Medicines. |
IUPAC Name |
2-ethylpyridine-4-carbothioamide |
International Nonproprietary Names | |
INN number | INN |
867 | ethionamide |
Synonyms |
1314 TH | Bayer 5312 | Trecator® |
Database Links | |
BindingDB Ligand | 50239976 |
CAS Registry No. | 536-33-4 (source: Scifinder) |
ChEBI | CHEBI:4885 |
ChEMBL Ligand | CHEMBL1441 |
DrugBank Ligand | DB00609 |
DrugCentral Ligand | 1083 |
GtoPdb PubChem SID | 485206075 |
PubChem CID | 2761171 |
RCSB PDB Ligand | 1JA |
Search Google for chemical match using the InChIKey | AEOCXXJPGCBFJA-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | AEOCXXJPGCBFJA |
Search PubMed clinical trials | ethionamide |
Search PubMed titles | ethionamide |
Search PubMed titles/abstracts | ethionamide |
UniChem Compound Search for chemical match using the InChIKey | AEOCXXJPGCBFJA-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | AEOCXXJPGCBFJA-UHFFFAOYSA-N |
Wikipedia | Ethionamide |