YM348 [Ligand Id: 230] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL407909 (YM-348) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| ChEMBL | Displacement of [3H]5-HT from human 5HT2A receptor expressed in CHO cells | B | 7.89 | pKi | 13 | nM | Ki | Bioorg Med Chem (2008) 16: 1966-1982 [PMID:18035544] |
| ChEMBL | Displacement of [3H]5-HT from human 5HT2A receptor expressed in CHO cells | B | 7.89 | pKi | 13 | nM | Ki | Bioorg Med Chem (2008) 16: 3309-3320 [PMID:18083579] |
| ChEMBL | Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis | F | 7.03 | pEC50 | 93 | nM | EC50 | Bioorg Med Chem (2008) 16: 1966-1982 [PMID:18035544] |
| ChEMBL | Agonist activity at Homo sapiens (human) 5-HT2A receptor assessed as 5-HT-induced phosphoinositide hydrolysis by cell based assay | B | 7.03 | pEC50 | 93 | nM | EC50 | Med Chem Res (2012) 21: 1491-1508 |
| 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
| ChEMBL | Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells | B | 8.6 | pKi | 2.5 | nM | Ki | Bioorg Med Chem (2008) 16: 3309-3320 [PMID:18083579] |
| ChEMBL | Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis | F | 8.49 | pEC50 | 3.2 | nM | EC50 | Bioorg Med Chem (2008) 16: 1966-1982 [PMID:18035544] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| GtoPdb | - | - | 9 | pKi | - | - | - | Eur J Pharmacol (2004) 483: 37-43 [PMID:14709324] |
| ChEMBL | Displacement of [3H]5-HT from human 5HT2C receptor expressed in CHO cells | B | 9.05 | pKi | 0.89 | nM | Ki | Bioorg Med Chem (2008) 16: 1966-1982 [PMID:18035544] |
| ChEMBL | Displacement of [3H]5-HT from human 5HT2C receptor expressed in CHO cells | B | 9.05 | pKi | 0.89 | nM | Ki | Bioorg Med Chem (2008) 16: 3309-3320 [PMID:18083579] |
| ChEMBL | Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis | F | 9 | pEC50 | 1 | nM | EC50 | Bioorg Med Chem (2008) 16: 1966-1982 [PMID:18035544] |
| ChEMBL | Agonist activity at Homo sapiens (human) 5-HT2C receptor assessed as 5-HT-induced phosphoinositide hydrolysis by cell based assay | B | 9 | pEC50 | 1 | nM | EC50 | Med Chem Res (2012) 21: 1491-1508 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
