NH-3 [Ligand Id: 2633] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL109279 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Thyroid hormone receptor-α/Thyroid hormone receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1860] [GtoPdb: 588] [UniProtKB: P10827] | ||||||||
| ChEMBL | Binding affinity against human Thyroid hormone receptor alpha-1 (hTRalpha1) using radiolabeled T3 | B | 7.03 | pKd | 93 | nM | Kd | J Med Chem (2002) 45: 3310-3320 [PMID:12109914] |
| GtoPdb | - | - | 7.62 | pKd | - | - | - | J Med Chem (2002) 45: 3310-20 [PMID:12109914] |
| ChEMBL | Half-maximum activation of human Thyroid hormone receptor alpha-1 (hTRalpha1) | B | 6.02 | pIC50 | 950 | nM | IC50 | J Med Chem (2002) 45: 3310-3320 [PMID:12109914] |
| Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1947] [GtoPdb: 589] [UniProtKB: P10828] | ||||||||
| GtoPdb | - | - | 7.03 | pKd | - | - | - | J Med Chem (2002) 45: 3310-20 [PMID:12109914] |
| ChEMBL | Binding affinity against human Thyroid hormone receptor beta 1 (hTRbeta1) using radiolabeled T3 | B | 7.7 | pKd | 20 | nM | Kd | J Med Chem (2002) 45: 3310-3320 [PMID:12109914] |
| ChEMBL | Half-maximum activation of human Thyroid hormone receptor beta 1 (hTRbeta1) | B | 6.43 | pIC50 | 370 | nM | IC50 | J Med Chem (2002) 45: 3310-3320 [PMID:12109914] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
