NH-3 [Ligand Id: 2633] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL109279
  • Thyroid hormone receptor-α/Thyroid hormone receptor alpha in Human [ChEMBL: CHEMBL1860] [GtoPdb: 588] [UniProtKB: P10827]
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  • Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Human [ChEMBL: CHEMBL1947] [GtoPdb: 589] [UniProtKB: P10828]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Thyroid hormone receptor-α/Thyroid hormone receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1860] [GtoPdb: 588] [UniProtKB: P10827]
ChEMBL Binding affinity against human Thyroid hormone receptor alpha-1 (hTRalpha1) using radiolabeled T3 B 7.03 pKd 93 nM Kd J. Med. Chem. (2002) 45: 3310-3320 [PMID:12109914]
GtoPdb - - 7.62 pKd - - - J. Med. Chem. (2002) 45: 3310-20 [PMID:12109914]
ChEMBL Half-maximum activation of human Thyroid hormone receptor alpha-1 (hTRalpha1) B 6.02 pIC50 950 nM IC50 J. Med. Chem. (2002) 45: 3310-3320 [PMID:12109914]
Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1947] [GtoPdb: 589] [UniProtKB: P10828]
GtoPdb - - 7.03 pKd - - - J. Med. Chem. (2002) 45: 3310-20 [PMID:12109914]
ChEMBL Binding affinity against human Thyroid hormone receptor beta 1 (hTRbeta1) using radiolabeled T3 B 7.7 pKd 20 nM Kd J. Med. Chem. (2002) 45: 3310-3320 [PMID:12109914]
ChEMBL Half-maximum activation of human Thyroid hormone receptor beta 1 (hTRbeta1) B 6.43 pIC50 370 nM IC50 J. Med. Chem. (2002) 45: 3310-3320 [PMID:12109914]

ChEMBL data shown on this page come from version 25:

A.P. Bento, A. Gaulton, A. Hersey, et al. (2014). The ChEMBL bioactivity database: an update. Nucl. Acids Res. Database Issue. 42 D1083-D1090. [PMID:24214965]