ADP [Ligand Id: 1712] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL14830 (Adenosine diphosphate, ADP)
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  • heat shock protein family A (Hsp70) member 8/Heat shock cognate 71 kDa protein in Human [ChEMBL: CHEMBL1275223] [GtoPdb: 2543] [UniProtKB: P11142]
  • Heat shock cognate 71 kDa protein in Bovine [ChEMBL: CHEMBL1275213] [UniProtKB: P19120]
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  • TNF receptor associated protein 1/Heat shock protein 75 kDa, mitochondrial in Human [ChEMBL: CHEMBL1075132] [GtoPdb: 2909] [UniProtKB: Q12931]
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  • heat shock protein 90 alpha family class A member 1/Heat shock protein HSP 90-alpha in Human [ChEMBL: CHEMBL3880] [GtoPdb: 2905] [UniProtKB: P07900]
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  • heat shock protein 90 alpha family class B member 1/Heat shock protein HSP 90-beta in Human [ChEMBL: CHEMBL4303] [GtoPdb: 2907] [UniProtKB: P08238]
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  • mitogen-activated protein kinase kinase kinase 7/Mitogen-activated protein kinase kinase kinase 7 in Human [ChEMBL: CHEMBL5776] [GtoPdb: 2082] [UniProtKB: O43318]
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  • P2Y1 receptor/Purinergic receptor P2Y1 in Human [ChEMBL: CHEMBL4315] [GtoPdb: 323] [UniProtKB: P47900]
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  • P2Y11 receptor/Purinergic receptor P2Y11 in Human [ChEMBL: CHEMBL4867] [GtoPdb: 327] [UniProtKB: Q96G91]
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  • P2Y12 receptor in Human [GtoPdb: 328] [UniProtKB: Q9H244]
  • P2Y12 receptor/Purinergic receptor P2Y12 in Rat [ChEMBL: CHEMBL2188] [GtoPdb: 328] [UniProtKB: Q9EPX4]
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  • P2Y2 receptor/Purinergic receptor P2Y2 in Human [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231]
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  • P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Human [ChEMBL: CHEMBL4714] [GtoPdb: 326] [UniProtKB: Q15077]
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  • P2Y13 receptor in Human [GtoPdb: 329] [UniProtKB: Q9BPV8]
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  • TRPM4 in Human [GtoPdb: 496] [UniProtKB: Q8TD43]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Ecto-5'-Nucleotidase/5'-nucleotidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075214] [GtoPdb: 1232] [UniProtKB: P21588]
ChEMBL Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis method B 9.04 pKi 0.91 nM Ki J. Med. Chem. (2010) 53: 2076-2086 [PMID:20146483]
78 kDa glucose-regulated protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781865] [UniProtKB: P11021]
ChEMBL Binding affinity to Grp78 by isothermal titration calorimetric analysis B 5.42 pKd 3830 nM Kd J. Med. Chem. (2011) 54: 4034-4041 [PMID:21526763]
ChEMBL Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis B 5.66 pKd 2170 nM Kd J. Med. Chem. (2011) 54: 4034-4041 [PMID:21526763]
heat shock protein family A (Hsp70) member 8/Heat shock cognate 71 kDa protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1275223] [GtoPdb: 2543] [UniProtKB: P11142]
ChEMBL Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysis B 6.49 pKd 323.59 nM Kd J. Med. Chem. (2016) 59: 4625-4636 [PMID:27119979]
ChEMBL Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysis B 6.49 pKd 320 nM Kd J. Med. Chem. (2016) 59: 4625-4636 [PMID:27119979]
ChEMBL Binding affinity to human Hsc70 by isothermal calorimetry assay B 6.59 pKd 260 nM Kd J. Med. Chem. (2010) 53: 7280-7286 [PMID:20608738]
Heat shock cognate 71 kDa protein in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1275213] [UniProtKB: P19120]
ChEMBL Binding affinity to bovine Hsc70 by filter binding assay B 6.96 pKd 110 nM Kd J. Med. Chem. (2010) 53: 7280-7286 [PMID:20608738]
TNF receptor associated protein 1/Heat shock protein 75 kDa, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075132] [GtoPdb: 2909] [UniProtKB: Q12931]
ChEMBL Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid from recombinant human Trap-1 after 24 hrs by fluorescence polarization assay B 4.25 pIC50 55594 nM IC50 J. Med. Chem. (2013) 56: 6803-6818 [PMID:23965125]
Heat shock protein 90 beta in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4748] [UniProtKB: P41148]
ChEMBL Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid from dog Grp94 after 24 hrs by fluorescence polarization assay B 4.94 pIC50 11447 nM IC50 J. Med. Chem. (2013) 56: 6803-6818 [PMID:23965125]
ChEMBL Inhibition of BODIPY-AG binding to dog Grp94 B 4.68 pEC50 21000 nM EC50 J. Med. Chem. (2006) 49: 4606-4615 [PMID:16854066]
heat shock protein 90 alpha family class A member 1/Heat shock protein HSP 90-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3880] [GtoPdb: 2905] [UniProtKB: P07900]
ChEMBL Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid from HSP90alpha (unknown origin) after 24 hrs by fluorescence polarization assay B 4.23 pIC50 59308 nM IC50 J. Med. Chem. (2013) 56: 6803-6818 [PMID:23965125]
heat shock protein 90 alpha family class B member 1/Heat shock protein HSP 90-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4303] [GtoPdb: 2907] [UniProtKB: P08238]
ChEMBL Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid from recombinant HSP90beta (unknown origin) after 24 hrs by fluorescence polarization assay B 4.38 pIC50 42159 nM IC50 J. Med. Chem. (2013) 56: 6803-6818 [PMID:23965125]
mitogen-activated protein kinase kinase kinase 7/Mitogen-activated protein kinase kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5776] [GtoPdb: 2082] [UniProtKB: O43318]
ChEMBL Binding affinity to recombinant human biotinylated N-terminal GST-tagged non-autophosphorylated TAK1 (1 to 303 residues) fused with TAB1 (437 to 504 residues) expressed in baculovirus infected sf9 cells by SPR assay B 4.2 pKd 63000 nM Kd Bioorg Med Chem Lett (2017) 27: 1031-1036 [PMID:28109791]
ChEMBL Binding affinity to recombinant human biotinylated N-terminal GST-tagged autophosphorylated TAK1 (1 to 303 residues) fused with TAB1 (437 to 504 residues) expressed in baculovirus infected sf9 cells by SPR assay B 5.39 pKd 4100 nM Kd Bioorg Med Chem Lett (2017) 27: 1031-1036 [PMID:28109791]
P2X1/P2X purinoceptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2094] [GtoPdb: 478] [UniProtKB: P51575]
ChEMBL Antagonist activity against recombinant human P2X purinoceptor 1 (P2X1 ) F 5 pEC50 10000 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2X2/P2X purinoceptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2531] [GtoPdb: 479] [UniProtKB: Q9UBL9]
ChEMBL The compound was evaluated for antagonist activity against recombinant human receptor P2X purinoceptor 2 (P2X2 ) F 4 pEC50 >100000 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2X3/P2X purinoceptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2998] [GtoPdb: 480] [UniProtKB: P56373]
ChEMBL Antagonist activity against recombinant human P2X purinoceptor 3 (P2X3 ) F 4 pEC50 >100000 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2X4/P2X purinoceptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2818] [GtoPdb: 481] [UniProtKB: P51577]
ChEMBL Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 30 uM, expressed in Xenopus oocytes F 4.55 pEC50 28000 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2X5/P2X purinoceptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2495] [GtoPdb: 482] [UniProtKB: P51578]
ChEMBL Antagonist activity against recombinant rat P2X purinoceptor 5 (P2X5) F 4.74 pEC50 18000 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2X6/P2X purinoceptor 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2122] [GtoPdb: 483] [UniProtKB: P51579]
ChEMBL Antagonist activity against recombinant rat P2X purinoceptor 6 (P2X6 ) F 4.96 pEC50 11000 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2Y purinoceptor 1 in Turkey (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5720] [UniProtKB: P49652]
ChEMBL Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytes F 5.1 pEC50 8000 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
ChEMBL Agonist activity at turkey P2Y1 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis F 7 pEC50 100 nM EC50 Eur. J. Med. Chem. (2009) 44: 1525-1536 [PMID:18760862]
P2Y1 receptor/Purinergic receptor P2Y1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4315] [GtoPdb: 323] [UniProtKB: P47900]
GtoPdb - - 7.2 pIC50 - - - Br. J. Pharmacol. (1997) 121: 338-44 [PMID:9154346];
Mol. Pharmacol. (2002) 62: 1249-57 [PMID:12391289]
ChEMBL Agonist activity at human GFP-tagged P2Y1R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay F 7.62 pEC50 24 nM EC50 J. Med. Chem. (2013) 56: 4938-4952 [PMID:23751098]
ChEMBL Agonist activity at GFP-tagged human P2Y1R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay B 7.62 pEC50 24 nM EC50 J. Med. Chem. (2015) 58: 8427-8443 [PMID:26447940]
ChEMBL Agonist activity at G-protein coupled P2Y1 receptor expressed in human 1321N1 cells assessed as increase in calcium by Fura2 assay F 7.85 pEC50 14 nM EC50 J. Med. Chem. (2010) 53: 2472-2481 [PMID:20175517]
P2Y11 receptor/Purinergic receptor P2Y11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4867] [GtoPdb: 327] [UniProtKB: Q96G91]
ChEMBL Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay F 5.77 pEC50 1700 nM EC50 J. Med. Chem. (2013) 56: 4938-4952 [PMID:23751098]
ChEMBL Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay B 5.77 pEC50 1700 nM EC50 J. Med. Chem. (2015) 58: 8427-8443 [PMID:26447940]
P2Y12 receptor in Human [GtoPdb: 328] [UniProtKB: Q9H244]
GtoPdb - - 5.9 pKi - - - Semin Vasc Med (2003) 3: 113-22 [PMID:15199474]
P2Y12 receptor/Purinergic receptor P2Y12 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2188] [GtoPdb: 328] [UniProtKB: Q9EPX4]
ChEMBL Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12) F 7.16 pEC50 69 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2Y2 receptor/Purinergic receptor P2Y2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231]
ChEMBL Evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 2 (P2Y2) F 4 pEC50 >100000 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4714] [GtoPdb: 326] [UniProtKB: Q15077]
ChEMBL Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP production F 4.19 pEC50 65000 nM EC50 J. Med. Chem. (2006) 49: 5532-5543 [PMID:16942026]
GtoPdb - - 4.5 pEC50 - - - Biochem. Biophys. Res. Commun. (1996) 222: 303-8 [PMID:8670200]
Sensor protein kinase WalK in S.aureus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295968] [UniProtKB: Q9RDT3]
ChEMBL Inhibition of Streptococcus pneumoniae VicK autophosphorylation using compound at non-aggregating concentration after 30 mins in presence of [gamma-33P]-ATP by phosphorescence-based assay B 5.14 pIC50 7189 nM IC50 Bioorg Med Chem (2018) 26: 5322-5326 [PMID:29706527]
P2Y13 receptor in Human [GtoPdb: 329] [UniProtKB: Q9BPV8]
GtoPdb - - 6.5 pIC50 - - - Mol. Pharmacol. (2003) 64: 104-12 [PMID:12815166]
TRPM4 in Human [GtoPdb: 496] [UniProtKB: Q8TD43]
GtoPdb - - 5.7 pIC50 - - - Pflugers Arch. (2004) 448: 70-5 [PMID:14758478]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]