revefenacin

Ligand id: 10129

Name: revefenacin

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 13
Topological polar surface area 108.21
Molecular weight 597.33
XLogP 4.08
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (2018))
IUPAC Name
[1-[2-[[4-[(4-carbamoylpiperidin-1-yl)methyl]benzoyl]-methylamino]ethyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate
International Nonproprietary Names
INN number INN
10112 revefenacin
Synonyms
GSK-1160724 | GSK1160724 | TD4208 | Yupelri®
Comments
Revefenacin (TD-4208) is a potent and long-acting muscarinic cholinergic receptor (mAChR) antagonist (LAMA) that has bronchodilatory effects [1-2], and which is approved for the management of chronic obstructive pulmonary disease (COPD). mAChR antagonists are the core agents used as first-line therapy for COPD. Revefenacin acts as a competitive antagonist at all 5 human mAChRs [1].
Database Links
CAS Registry No. 864750-70-9 (source: WHO INN record)
ChEMBL Ligand CHEMBL3833319
DrugBank Ligand DB11855
GtoPdb PubChem SID 381118839
PubChem CID 11753673
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